Phosphoprotein dynamics of interacting T cells and tumor cells by HySic

Summary: Functional interactions between cytotoxic T cells and tumor cells are central to anti-cancer immunity. However, our understanding of the proteins involved is limited. Here, we present HySic (hybrid quantification of stable isotope labeling by amino acids in cell culture [SILAC]-labeled inte...

Full description

Bibliographic Details
Published in:	Cell Reports
Main Authors:	Sofía Ibáñez-Molero, Joannes T.M. Pruijs, Alisha Atmopawiro, Fujia Wang, Alexandra M. Terry, Maarten Altelaar, Daniel S. Peeper, Kelly E. Stecker
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Subjects:	CP: Immunology CP: Cancer
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124723016108

Similar Items

NK cells propagate T cell immunity following in situ tumor vaccination
by: Won Jong Jin, et al.
Published: (2023-12-01)

Cell-intrinsic PD-L1 ablation sustains effector CD8+ T cell responses and promotes antitumor T cell therapy
by: Xinran Wang, et al.
Published: (2024-02-01)

An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade
by: Diede Houbaert, et al.
Published: (2024-04-01)

XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells
by: Tao Zou, et al.
Published: (2024-02-01)

DA-DRD5 signaling reprograms B cells to promote CD8+ T cell-mediated antitumor immunity
by: Yuqing Wu, et al.
Published: (2025-03-01)

STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells
by: Lu Lu, et al.
Published: (2023-09-01)

Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity
by: Anirudh Patir, et al.
Published: (2024-05-01)

Tuft cells trigger neurogenic inflammation in the urethra
by: Patricia Schmidt, et al.
Published: (2025-10-01)

Prostate cancer cell-derived exosomal IL-8 fosters immune evasion by disturbing glucolipid metabolism of CD8+ T cell
by: Fan Xu, et al.
Published: (2023-11-01)

Flt3L enhances clonal diversification and selective expansion of intratumoral CD8+ T cells while differentiating into effector-like cells
by: Dongmin Chun, et al.
Published: (2024-12-01)

Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity
by: Anna-Marie Pedde, et al.
Published: (2024-11-01)

Exogenous estrogen enhances T cell activation in male primates
by: Patricia A. Hahn, et al.
Published: (2025-09-01)

Acquisition of residency programs by T cells entering the human brain
by: Cheng-Chih Hsiao, et al.
Published: (2025-07-01)

A binary module for microbiota-mediated regulation of γδ17 cells, hallmarked by microbiota-driven expression of programmed cell death protein 1
by: Hsin-I Huang, et al.
Published: (2023-08-01)

Microenvironmental β-TrCP negates amino acid transport to trigger CD8+ T cell exhaustion in human non-small cell lung cancer
by: Ge Li, et al.
Published: (2025-01-01)

The microbiota and T cells non-genetically modulate inherited phenotypes transgenerationally
by: Jordan C. Harris, et al.
Published: (2024-04-01)

An axon-T cell feedback loop enhances inflammation and axon degeneration
by: Tingting Liu, et al.
Published: (2024-02-01)

Plasmacytoid dendritic cells during COVID-19: Ally or adversary?
by: Renée Marije Van der Sluis, et al.
Published: (2022-07-01)

A dhesion analysis via a tumor vasculature-like microfluidic device identifies CD8+ T cells with enhanced tumor homing to improve cell therapy
by: Camila P. Camargo, et al.
Published: (2023-03-01)

A vascular-associated fibroblastic cell controls pancreatic islet immunity
by: Don Clarke, et al.
Published: (2025-09-01)

Engineering of dendritic cell bispecific extracellular vesicles for tumor-targeting immunotherapy
by: Fang Xu, et al.
Published: (2023-10-01)

EZH2 inhibition mitigates HIV immune evasion, reduces reservoir formation, and promotes skewing of CD8+ T cells toward less-exhausted phenotypes
by: Andrea Gramatica, et al.
Published: (2025-05-01)

CpsA mediates infection of recruited lung myeloid cells by Mycobacterium tuberculosis
by: Steven J. Grigsby, et al.
Published: (2024-01-01)

JAML immunotherapy targets recently activated tumor-infiltrating CD8+ T cells
by: Simon Eschweiler, et al.
Published: (2023-02-01)

T cell-mediated curation and restructuring of tumor tissue coordinates an effective immune response
by: John W. Hickey, et al.
Published: (2023-12-01)

MAIT cells activate dendritic cells to promote TFH cell differentiation and induce humoral immunity
by: Theresa E. Pankhurst, et al.
Published: (2023-04-01)

Stress regulates Alzheimer’s disease progression via selective enrichment of CD8+ T cells
by: Yilin Feng, et al.
Published: (2023-10-01)

High frequency of HIV precursor-target-specific B cells in sub-Saharan populations
by: Flavio Matassoli, et al.
Published: (2023-12-01)

Spatial resolution of HIV-1 post-entry steps in resting CD4 T cells
by: Swetha Ananth, et al.
Published: (2024-03-01)

DOT1L maintains NK cell phenotype and function for optimal tumor control
by: Harrison Sudholz, et al.
Published: (2024-06-01)

The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity
by: Cristiano De Sá Fernandes, et al.
Published: (2024-06-01)

Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma
by: Michael T. Patterson, et al.
Published: (2023-07-01)

Hypoxic stress dysregulates functions of glioma-associated myeloid cells through epigenomic and transcriptional programs
by: Monika Dzwigonska, et al.
Published: (2025-09-01)

Gut bacterial L-lysine alters metabolism and histone methylation to drive dendritic cell tolerance
by: Qiang Tang, et al.
Published: (2025-01-01)

Plasmodium infection induces phenotypic, clonal, and spatial diversity among differentiating CD4+ T cells
by: Cameron G. Williams, et al.
Published: (2024-06-01)

MHC class II regulation of CD8+ T cell tolerance and implications in autoimmunity and cancer immunotherapy
by: Xiaojuan Zhou, et al.
Published: (2023-11-01)

Single-cell analysis reveals a weak macrophage subpopulation response to Mycobacterium tuberculosis infection
by: Sydney L. Solomon, et al.
Published: (2023-11-01)

Acod1 expression in cancer cells promotes immune evasion through the generation of inhibitory peptides
by: James H. Schofield, et al.
Published: (2024-04-01)

Precision off-the-shelf natural killer cell therapies for oncology with logic-gated gene circuits
by: Nicholas W. Frankel, et al.
Published: (2024-05-01)

Leishmania infantum exploits the anti-ferroptosis effects of Nrf2 to escape cell death in macrophages
by: Clément Blot, et al.
Published: (2024-09-01)