Renal mitochondrial oxidative stress is enhanced by the reduction of Sirt3 activity, in Zucker diabetic fatty rats

Objectives: Mitochondrial oxidative stress is involved in the pathogenesis of diabetic kidney disease. The objective of our study is to identify the mechanisms of renal mitochondrial oxidative stress, focusing on Sirt3, which is nicotinamide adenine dinucleotide (NAD+; oxidized NAD)-dependent deacet...

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Bibliographic Details
Published in:	Redox Report
Main Authors:	Yoshio Ogura, Munehiro Kitada, Itaru Monno, Keizo Kanasaki, Ai Watanabe, Daisuke Koya
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2018-01-01
Subjects:	Diabetic kidney disease Zucker diabetic fatty rat Sirt3 mitochondrial oxidative stress isocitrate dehydrogenase2 superoxide dismutase2 CD38 NAD+/NADH ratio
Online Access:	http://dx.doi.org/10.1080/13510002.2018.1487174

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