Potential value of efficacy prediction and treatment of natural killer cells in extensive stage small cell lung cancer
Abstract Although the emergence of immunotherapy has broken the deadlock of extensive stage small cell lung cancer (ES‐SCLC), the study of markers for predicting efficacy is the key to the breakthrough of immunotherapy, and exploring more innovative, efficient and safe treatment models is also an im...
| الحاوية / القاعدة: | Thoracic Cancer |
|---|---|
| المؤلفون الرئيسيون: | , , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
Wiley
2023-04-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://doi.org/10.1111/1759-7714.14837 |
| _version_ | 1850143564293472256 |
|---|---|
| author | Yanan Cui Peiyan Zhao Ying Cheng Xiubao Ren |
| author_facet | Yanan Cui Peiyan Zhao Ying Cheng Xiubao Ren |
| author_sort | Yanan Cui |
| collection | DOAJ |
| container_title | Thoracic Cancer |
| description | Abstract Although the emergence of immunotherapy has broken the deadlock of extensive stage small cell lung cancer (ES‐SCLC), the study of markers for predicting efficacy is the key to the breakthrough of immunotherapy, and exploring more innovative, efficient and safe treatment models is also an important research direction of ES‐SCLC. As an important part of inherent immunity, natural killer (NK) cells have become a hot spot because activated NK cells can directly kill tumor cells and may also influence tumor microenvironment immunomodulation. To date, emerging experimental research on NK cells in tumor therapy and immunoregulation has been published, but specific reviews of its role in ES‐SCLC are limited. Hence, in this review, we briefly summarize the current status of immunotherapy and the exploration of biomarker in ES‐SCLCs, with focus on the potential value of efficacy prediction and treatment of NK cells, and finally discuss the limitations and development prospects of NK cells in ES‐SCLC immunotherapy research. |
| format | Article |
| id | doaj-art-e65178ed5e464120abaa2153d052d9f1 |
| institution | Directory of Open Access Journals |
| issn | 1759-7706 1759-7714 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| spelling | doaj-art-e65178ed5e464120abaa2153d052d9f12025-08-19T23:48:17ZengWileyThoracic Cancer1759-77061759-77142023-04-01141086487210.1111/1759-7714.14837Potential value of efficacy prediction and treatment of natural killer cells in extensive stage small cell lung cancerYanan Cui0Peiyan Zhao1Ying Cheng2Xiubao Ren3Division of Thoracic Oncology Jilin Cancer Hospital Changchun ChinaTranslational Oncology Research Lab Jilin Cancer Hospital Changchun ChinaDivision of Thoracic Oncology Jilin Cancer Hospital Changchun ChinaDepartment of Biotherapy Tianjin Medical University Cancer Institute & Hospital Tianjin ChinaAbstract Although the emergence of immunotherapy has broken the deadlock of extensive stage small cell lung cancer (ES‐SCLC), the study of markers for predicting efficacy is the key to the breakthrough of immunotherapy, and exploring more innovative, efficient and safe treatment models is also an important research direction of ES‐SCLC. As an important part of inherent immunity, natural killer (NK) cells have become a hot spot because activated NK cells can directly kill tumor cells and may also influence tumor microenvironment immunomodulation. To date, emerging experimental research on NK cells in tumor therapy and immunoregulation has been published, but specific reviews of its role in ES‐SCLC are limited. Hence, in this review, we briefly summarize the current status of immunotherapy and the exploration of biomarker in ES‐SCLCs, with focus on the potential value of efficacy prediction and treatment of NK cells, and finally discuss the limitations and development prospects of NK cells in ES‐SCLC immunotherapy research.https://doi.org/10.1111/1759-7714.14837extensive stage small cell lung cancerimmunotherapynatural killer cells |
| spellingShingle | Yanan Cui Peiyan Zhao Ying Cheng Xiubao Ren Potential value of efficacy prediction and treatment of natural killer cells in extensive stage small cell lung cancer extensive stage small cell lung cancer immunotherapy natural killer cells |
| title | Potential value of efficacy prediction and treatment of natural killer cells in extensive stage small cell lung cancer |
| title_full | Potential value of efficacy prediction and treatment of natural killer cells in extensive stage small cell lung cancer |
| title_fullStr | Potential value of efficacy prediction and treatment of natural killer cells in extensive stage small cell lung cancer |
| title_full_unstemmed | Potential value of efficacy prediction and treatment of natural killer cells in extensive stage small cell lung cancer |
| title_short | Potential value of efficacy prediction and treatment of natural killer cells in extensive stage small cell lung cancer |
| title_sort | potential value of efficacy prediction and treatment of natural killer cells in extensive stage small cell lung cancer |
| topic | extensive stage small cell lung cancer immunotherapy natural killer cells |
| url | https://doi.org/10.1111/1759-7714.14837 |
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