| Summary: | Abstract Objective This study was undertaken to examine incidence and predictors of delirium in acute aortic syndrome (AAS) patients with or without surgery, and to evaluate its association with early and follow-up outcomes. Methods A cross-sectional study was retrospectively performed at a single center using a database that was prospectively maintained between 2019 and 2021. Measured outcomes included postoperative results and both early and follow-up survival rates. Results Five hundred ninety-two AAS patients were recruited. Delirium was seen in 31.6% (187/592) of patients. Predictors of delirium included the use of sedatives (odds ratio (OR) = 16.490, 95%-confidence interval (CI) = 8.981–30.279, P < 0.001) and sodium nitroprusside (OR = 2.676, 95%CI = 1.729–4.142, P < 0.001). Delirium was revealed as a risk factor for length of hospital stay (LOS) (OR = 1.101, 95%CI = 1.023–1.185, P < 0.05) and prolonged intensive care unit (ICU) stay (OR = 3.073, 95% CI = 1.744–5.415, P < 0.001). Conclusion The incidence of delirium in AAS patients is 31.6%, significantly increasing LOS and ICU stay duration. The use of sedatives and sodium nitroprusside were revealed as risk factors for delirium.
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