Urokinase Receptor and Resistance to Targeted Anticancer Agents

The urokinase receptor/uPAR is a GPI-anchored membrane protein, which regulates protease activity at the cell surface and, in collaboration with a system of co-receptors, triggers cell-signaling and regulates gene expression within the cell. In normal tissues, uPAR gene expression is limited; howev...

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Bibliographic Details
Published in:	Frontiers in Pharmacology
Main Authors:	Steven L. Gonias, Jingjing eHu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2015-07-01
Subjects:	Epithelial-Mesenchymal Transition Fibrinolysis metastasis Cancer stem cell cellular senescence uPAR
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00154/full

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