Propofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA<sub>A </sub>receptor chloride channels

<p>Abstract</p> <p>Propofol is a widely used intravenous general anesthetic. Propofol-induced unconsciousness in humans is associated with inhibition of thalamic activity evoked by somatosensory stimuli. However, the cellular mechanisms underlying the effects of propofol in thalami...

Full description

Bibliographic Details
Published in:	Molecular Pain
Main Authors:	Goldstein Peter A, Ying Shui-Wang
Format:	Article
Language:	English
Published:	SAGE Publishing 2005-01-01
Online Access:	http://www.molecularpain.com/content/1/1/2

Similar Items

GABA Neuronal Deletion of Shank3 Exons 14–16 in Mice Suppresses Striatal Excitatory Synaptic Input and Induces Social and Locomotor Abnormalities
by: Taesun Yoo, et al.
Published: (2018-10-01)

Axonal dynamics of excitatory and inhibitory neurons in somatosensory cortex.
by: Sally A Marik, et al.
Published: (2010-06-01)

Adenosine Inhibits the Excitatory Synaptic Inputs to Basal Forebrain Cholinergic, GABAergic and Parvalbumin Neurons in mice
by: Chun eYang, et al.
Published: (2013-06-01)

Excessive firing of dyskinesia-associated striatal direct pathway neurons is gated by dopamine and excitatory synaptic input
by: Michael B. Ryan, et al.
Published: (2024-08-01)

Adult-born neurons modify excitatory synaptic transmission to existing neurons
by: Elena W Adlaf, et al.
Published: (2017-01-01)

Synaptic microarchitecture: the role of spatial interplay between excitatory and inhibitory inputs in shaping dendritic plasticity and neuronal output
by: Dario Cupolillo, et al.
Published: (2024-12-01)

Ammonium chloride reduces excitatory synaptic transmission onto CA1 pyramidal neurons of mouse organotypic slice cultures
by: Dimitrios Kleidonas, et al.
Published: (2024-10-01)

Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits
by: Mingming Xing, et al.
Published: (2024-10-01)

Neurosteroid Modulation of Synaptic and Extrasynaptic GABA<sub>A</sub> Receptors of the Mouse Nucleus Accumbens
by: Scott J. Mitchell, et al.
Published: (2024-04-01)

Extra-Synaptic GABA<sub>A</sub> Receptor Potentiation and Neurosteroid-Induced Learning Deficits Are Inhibited by GR3027, a GABA<sub>A</sub> Modulating Steroid Antagonist
by: Sara K. S. Bengtsson, et al.
Published: (2023-10-01)

Synaptic alterations and neuronal firing in human epileptic neocortical excitatory networks
by: Réka Bod, et al.
Published: (2023-08-01)

Dexmedetomidine Preserves Activity of Neurons in Primary Somatosensory Cortex Compared to Propofol and Ketamine
by: Mu-Chao Xia, et al.
Published: (2022-12-01)

A consensus definition for deep layer 6 excitatory neurons in mouse somatosensory, visual, and motor cortex
by: Su-Jeong Kim, et al.
Published: (2025-09-01)

Toluene alters the intrinsic excitability and excitatory synaptic transmission of basolateral amygdala neurons
by: Kevin Braunscheidel, et al.
Published: (2024-02-01)

SORAYA MEHRABI HIPPOCAMPAL CHLORIDE TRANSPORTER KCC2 CONTRIBUTES TO EXCITATORY GABA DYSREGULATION IN THE DEVELOPMENTAL RAT MODEL OF SCHIZOPHRENIA
by: Soraya Mehrabi
Published: (2023-10-01)

Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn
by: Kwan Yeop Lee, et al.
Published: (2019-11-01)

Metformin Enhances Excitatory Synaptic Transmission onto Hippocampal CA1 Pyramidal Neurons
by: Wen-Bing Chen, et al.
Published: (2020-10-01)

Lumbar V3 interneurons provide direct excitatory synaptic input onto thoracic sympathetic preganglionic neurons, linking locomotor, and autonomic spinal systems
by: Camila Chacon, et al.
Published: (2023-08-01)

Retinal input integration in excitatory and inhibitory neurons in the mouse superior colliculus in vivo
by: Carolin Gehr, et al.
Published: (2023-09-01)

GABA<sub>A</sub>-ρ Receptors in the CNS: Their Functional, Pharmacological, and Structural Properties in Neurons and Astroglia
by: Abraham Rosas-Arellano, et al.
Published: (2023-10-01)

Epipregnanolone as a Positive Modulator of GABA<sub>A</sub> Receptor in Rat Cerebellar and Hippocampus Neurons
by: Julia Bukanova, et al.
Published: (2021-05-01)

Shared and divergent principles of synaptic transmission between cortical excitatory neurons in rodent and human brain
by: Christiaan P. J. de Kock, et al.
Published: (2023-09-01)

Modification of the synaptic cleft under excitatory conditions
by: Jung-Hwa Tao-Cheng, et al.
Published: (2023-09-01)

GABA<sub>A</sub> and GABA<sub>B</sub> Receptors Mediate GABA-Induced Intracellular Ca<sup>2+</sup> Signals in Human Brain Microvascular Endothelial Cells
by: Sharon Negri, et al.
Published: (2022-11-01)

Defective Excitatory/Inhibitory Synaptic Balance and Increased Neuron Apoptosis in a Zebrafish Model of Dravet Syndrome
by: Alexandre Brenet, et al.
Published: (2019-10-01)

Inhibition of Rac1 in ventral hippocampal excitatory neurons improves social recognition memory and synaptic plasticity
by: Haiwang Zhang, et al.
Published: (2022-07-01)

Targeting light-gated chloride channels to neuronal somatodendritic domain reduces their excitatory effect in the axon
by: Jessica E Messier, et al.
Published: (2018-08-01)

Excitatory neuron-prone prion propagation and excitatory neuronal loss in prion-infected mice
by: Temuulen Erdenebat, et al.
Published: (2024-12-01)

Serotonin/GABA receptors modulate odor input to olfactory receptor neuron in locusts
by: Mingyue Lv, et al.
Published: (2023-04-01)

Loss of dysbindin-1 in excitatory neurons in mice impacts NMDAR-dependent behaviors, neuronal morphology and synaptic transmission in the ventral hippocampus
by: Sanjeev K. Bhardwaj, et al.
Published: (2024-07-01)

Connection changes in somatosensory cortex induced by different doses of propofol.
by: Zhaoduan Li, et al.
Published: (2014-01-01)

Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain
by: Joshua M. Lorenz-Guertin, et al.
Published: (2023-09-01)

Irregular persistent activity induced by synaptic excitatory feedback
by: Francesca Barbieri, et al.
Published: (2007-11-01)

Astrocyte chloride, excitatory-inhibitory balance and epilepsy
by: Verena Untiet, et al.
Published: (2024-01-01)

How pattern formation in ring networks of excitatory and inhibitoryspiking neurons depends on the input current regime
by: Birgit eKriener, et al.
Published: (2014-01-01)

GABA<sub>A</sub> and Glycine Receptor-Mediated Inhibitory Synaptic Transmission onto Adult Rat Lamina II<sub>i</sub> PKCγ-Interneurons: Pharmacological but Not Anatomical Specialization
by: Corinne El Khoueiry, et al.
Published: (2022-04-01)

Large-scale transcriptomic analyses of major depressive disorder reveal convergent dysregulation of synaptic pathways in excitatory neurons
by: Fernando S. Goes, et al.
Published: (2025-04-01)

Increased Excitability and Reduced Excitatory Synaptic Input Into Fast-Spiking CA2 Interneurons After Enzymatic Attenuation of Extracellular Matrix
by: Hussam Hayani, et al.
Published: (2018-05-01)

GABA Metabolism and Transport: Effects on Synaptic Efficacy
by: Fabian C. Roth, et al.
Published: (2012-01-01)

Non-monotonic effects of GABAergic synaptic inputs on neuronal firing.
by: Aghil Abed Zadeh, et al.
Published: (2022-06-01)