Economic prognosis from vaccination against meningococcal infection inclusion into the National calendar of prophylactic vaccines in children of first age old

• Published in: Качественная клиническая практика
• Main Authors: L. D. Popovich, D. A. Vakhrusheva, S. V. Svetlichnaya
• Format: Article
• Language: Russian
• Published: Izdatelstvo OKI 2022-08-01
• Subjects: менингококковая инфекция; вакцинопрофилактика; экономическое бремя; моделирование
• Online Access: https://www.clinvest.ru/jour/article/view/612

Meningococcal infection (MI) is one of the severe illnesses by clinical manifestations and their consequences. Specific prophylaxis of severe MI forms is the most effective measure in the current conditions. It can lead to morbidity and disability reduction as well as and economic burden cut. Aim. Potential economic benefits of society finding in case of meningococcal polysaccharide conjugate vaccine to prevent MI caused by serogroups A, C, W, and Y into the National calendar of prophylactic vaccines (NCPV) for children 9- and 12-months age. Material and methods. The dynamic simulation mathematical model for epidemiological consequences of MI vaccines prophylaxis inclusion into NCPV was created. And economic calculations have been made based on this model also. Cost of vaccination based on prognosis of children amount in age before one year has been calculated, monetary equivalent of economic burden reduction in case of MI vaccines prophylaxis inclusion into NCPV was created. Results. Vaccination reduces mortality on 58–60 %, especially in children less than 5 years old. Correlation of the total epidemiological benefits expressed in years of prevented years of lost life with the projected cost of a statistical year of life gives the following results: starting from the 1st year of vaccination of children, society will receive almost 6.5 billion RUR monetary gain in metrics of life saved years. Monetary benefit on 10 years horizon could be as 70 billion RUR. Conclusion. Expenditures for meningococcal polysaccharide conjugate vaccine to prevent MI caused by serogroups A, C, W, and Y usage in case of inclusion into NCPV for children in 9- and 12-months (twice in the first year of life) are economic proved in frames of monetary equivalent of society gain in certain conditions.