The Pathophysiology of Vasovagal Syncope and New Approaches to its Pharmacological Treatment

Syncope refers to the transient loss of consciousness and the most common type of syncope is vasovagal syncope (VVS), usually occurring when a person is in an upright position, and/or after exposure to intense stress. The sequelae of VVS is caused by an increase in sympathetic tone and heart rate co...

Full description

Bibliographic Details
Published in:	Journal of Cardiovascular Pharmacology and Therapeutics
Main Authors:	Dalyia Abu-Ghazaleh MD, David A. Taylor PhD, Louise Roberts PhD, Indu Singh PhD, Vinicius Cruzat PhD, Roselyn B. Rose’Meyer PhD
Format:	Article
Language:	English
Published:	SAGE Publishing 2025-06-01
Online Access:	https://doi.org/10.1177/10742484251351140

Similar Items

Cardioneuroablation for Drug Refractory Vasovagal Syncope After COVID-19 Infection
by: Stefanos Zafeiropoulos, MD, PhD, et al.
Published: (2024-07-01)

Catheter-Based Cardio-Neural Ablation for Refractory Vasovagal Syncope
by: Yu Lu, MD, PhD, et al.
Published: (2020-07-01)

Vasovagal syncope successfully treated with an atrial leadless pacemaker
by: Aileen M. Ferrick, PhD, RN, ACNP-BC, FHRS
Published: (2024-09-01)

Temperament and character personality dimensions in nitrate-tilt-induced vasovagal syncope patients
by: Vincenzo Russo, MD, PhD, MMSc, et al.
Published: (2017-11-01)

Cardioneuroablation for management of cardioinhibitory vasovagal syncope and pacemaker complications
by: Sebastian Stec, MD, PhD, FESC, et al.
Published: (2020-08-01)

Syncope Due to Iatrogenic Cava Vein Obstruction
by: Keiko Shimamoto, MD, PhD, et al.
Published: (2024-06-01)

Selective cardioneuroablation of the posteromedial left ganglionated plexus for drug-resistant swallow syncope with functional atrioventricular block
by: Fumiya Yoneda, MD, et al.
Published: (2023-08-01)

Mechanism of Jiedu Prescription in Hepatocellular Carcinoma: Integrating Network Pharmacology and Experimental Validation
by: Yuan Wu PhD, et al.
Published: (2025-10-01)

Syncope and loss of consciousness after implantation of a cardioverter-defibrillator in patients with Brugada syndrome: Prevalence and characteristics in long-term follow-up
by: Saori Asada, MD, PhD, et al.
Published: (2023-10-01)

Sudden arrhythmic death in patients with syncope and implantable cardiac monitor
by: Pilar Cabanas Grandío, MD, PhD, et al.
Published: (2024-11-01)

Coronary Microvascular Dysfunction May Be a Pathophysiological Mechanism in Patients with Wilson’s Disease
by: Alexander Moumtsidis, et al.
Published: (2024-01-01)

Current trends in evaluating and diagnosing syncope due to orthostatic hypotension: A case report
by: Margaret Harvey, PhD, ACNP-BC
Published: (2022-06-01)

Non-pharmacological methods of treatment and prevention of vasovagal syncope
by: Aleksandra Białkowska, et al.
Published: (2018-11-01)

Treatment of Vasovagal Syncope
by: Muhammed Oylumlu, et al.
Published: (2013-12-01)

Neurocardiogenic (Vasovagal) Syncope
by: J Gordon Millichap
Published: (1994-04-01)

Pathophysiological and Prognostic Importance of an ExtraCardiac Comorbidity Burden in Patients with Heart Failure with Preserved Ejection Fraction
by: Yuki Saito, MD, PhD, et al.
Published: (2025-04-01)

Cassava ( Crantz): A Systematic Review for the Pharmacological Activities, Traditional Uses, Nutritional Values, and Phytochemistry
by: Siti Raudhah Noor Shifa Putri Mohidin BSc, et al.
Published: (2023-10-01)

Clinical Efficacy and Mechanistic Insights of Anshen Dingzhi Prescription on Breast Cancer-Related PTSD Through Network Pharmacology and Molecular Docking
by: Hao Zhang MD, et al.
Published: (2024-09-01)

The immunomodulatory activity of Orthosiphon aristatus against atopic dermatitis: Evidence-based on network pharmacology and molecular simulations
by: Thigita A. Pandaleke, M.D., et al.
Published: (2024-02-01)

Magnetic Resonance Imaging for Characterization of a Chick Embryo Model of Cancer Cell Metastases
by: Anne Herrmann PhD, et al.
Published: (2018-10-01)

Serum exosomal microRNA pathway activation in placenta accreta spectrum: pathophysiology and detectionAJOG Global Reports at a Glance
by: Jessian L. Munoz, MD, PhD, MPH, et al.
Published: (2024-02-01)

Preoperative factors affecting the two-year postoperative patient-reported outcome in single-level lumbar grade I degenerative spondylolisthesis
by: Tsukasa Kanchiku, PhD, et al.
Published: (2023-12-01)

The Effect of Intervention Approaches of Emotion Regulation and Learning Strategies on Students’ Learning and Mental Health
by: Elodie Charbonnier PhD, et al.
Published: (2023-03-01)

Determinants of Disaster Competencies Among Jordanian Nurses in Public Hospitals
by: Sajeda Alhamory PhD, et al.
Published: (2024-10-01)

Effectiveness of the Traditional Japanese Medicine Goshajinkigan in Preventing Paclitaxel-Induced Peripheral Neuropathy: A Multicenter Randomized Comparative Trial
by: Yukiko Matsumura PhD, et al.
Published: (2024-09-01)

Soil intake modifies the gut microbiota and alleviates Th2-type immune response in an ovalbumin-induced asthma mouse model
by: Mengjie Li, PhD, et al.
Published: (2024-04-01)

Well Leg Compartment Syndrome in the Thigh and Calf Caused by a Forced Prone Position after Syncope
by: Zhegang Zhou, MD, et al.
Published: (2024-08-01)

Pharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival From Sepsis
by: Patrick R. Lawler, MD, MPH, et al.
Published: (2023-11-01)

The Bone Cement Hypercoagulation Syndrome: Pathophysiology, Mortality, and Prevention
by: Ola E. Dahl MD, DocMedsci, et al.
Published: (2023-10-01)

Investigation of exacerbating factors for postpartum hair loss: a questionnaire-based cross-sectional study
by: Asuka Hirose, PhD, et al.
Published: (2023-06-01)

Implementation of a Quality Improvement Tool “Recover25” to Guide the Care of Patients Experiencing Prolonged Critical Illness: A Mixed-Method Feasibility Study
by: Laura Allum, MRes, et al.
Published: (2025-05-01)

Sex differences in efficacy of pharmacological therapies in heart failure with reduced ejection fraction: a meta‐analysis
by: Cecilia Danielson, et al.
Published: (2022-08-01)

Is There Room for Improvement? Stroke Rehabilitation Environments May Not Reflect Home Environments in Terms of Chair, Toilet, and Bed Heights
by: Katharine Scrivener, PhD, et al.
Published: (2024-09-01)

Macrophage Polarisation in the Tumour Microenvironment: Recent Research Advances and Therapeutic Potential of Different Macrophage Reprogramming
by: Rongqi Guo PhD, et al.
Published: (2025-01-01)

Comparative Evaluation of 2 Different Percutaneous Techniques of Simultaneous Needle Biopsy With Microwave Ablation of Suspected Malignant Pulmonary Nodules
by: Miaomiao Hu PhD, et al.
Published: (2023-04-01)

Association of Circulating Inflammatory Biomarker Levels and Toxicity in Patients Undergoing Pelvic Radiation for Cancer: A Critical Review
by: Per Fessé, PhD, et al.
Published: (2025-06-01)

Comparative research performance of top universities from the northeastern Brazil on three pharmacological disciplines as seen in scopus database
by: Jean P. Kamdem, PhD, et al.
Published: (2017-12-01)

MS-1
by: Sofia M. Pereira PhD, et al.
Published: (2016-04-01)

The Relationship Between the Nurse Practice Environment and Perceived Patient-Centered Care in Intensive Care Units: Nursing Perspective
by: Musab Bardhia MSN, et al.
Published: (2025-02-01)

Fibrous Dysplasia Polyostotic: When Radiology Clarifies the Diagnosis
by: Ihssane Lahlou PhD, et al.
Published: (2024-05-01)