The Ebola Virus Interferon Antagonist VP24 Undergoes Active Nucleocytoplasmic Trafficking

Viral interferon (IFN) antagonist proteins mediate evasion of IFN-mediated innate immunity and are often multifunctional, with distinct roles in viral replication. The Ebola virus IFN antagonist VP24 mediates nucleocapsid assembly, and inhibits IFN-activated signaling by preventing nuclear import of...

Full description

Bibliographic Details
Published in:	Viruses
Main Authors:	Angela R. Harrison, Cassandra T. David, Stephen M. Rawlinson, Gregory W. Moseley
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Subjects:	Ebola virus VP24 interferon antagonist nuclear transport nuclear export sequence
Online Access:	https://www.mdpi.com/1999-4915/13/8/1650

Similar Items

The Minor Matrix Protein VP24 from Ebola Virus Lacks Direct Lipid-Binding Properties
by: Yuan Su, et al.
Published: (2020-08-01)

Functional Importance of Hydrophobic Patches on the Ebola Virus VP35 IFN-Inhibitory Domain
by: Nodoka Kasajima, et al.
Published: (2021-11-01)

In Silico Study of Plant Polyphenols' Interactions with VP24–Ebola Virus Matrix Protein
by: Sebastian Pleško, et al.
Published: (2015-04-01)

The Biophysical Basis for Karyopherin-Dependent Ebola Virus VP24 Nuclear Transport
by: Junjie Zhao, et al.
Published: (2025-07-01)

Identification of nuclear localization signal and nuclear export signal of VP1 from the chicken anemia virus and effects on VP2 shuttling in cells
by: Jai-Hong Cheng, et al.
Published: (2019-04-01)

Ebolavirus Species-Specific Interferon Antagonism Mediated by VP24
by: Palaniappan Ramanathan, et al.
Published: (2023-04-01)

Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity
by: Lin Zhu, et al.
Published: (2024-01-01)

Corrigendum: Ebola VP40 in Exosomes Can Cause Immune Cell Dysfunction
by: Michelle L. Pleet, et al.
Published: (2018-04-01)

Computational Study on Potential Novel Anti-Ebola Virus Protein VP35 Natural Compounds
by: Louis K. S. Darko, et al.
Published: (2021-11-01)

Identification of Prospective Ebola Virus VP35 and VP40 Protein Inhibitors from Myxobacterial Natural Products
by: Muhammad Hayat, et al.
Published: (2024-06-01)

How SARS-CoV-2 and Other Viruses Build an Invasion Route to Hijack the Host Nucleocytoplasmic Trafficking System
by: Elma Sakinatus Sajidah, et al.
Published: (2021-06-01)

Evaluation of fendiline treatment in VP40 system with nucleation-elongation process: a computational model of Ebola virus matrix protein assembly
by: Xiao Liu, et al.
Published: (2024-04-01)

Quantification of Type I Interferon Inhibition by Viral Proteins: Ebola Virus as a Case Study
by: Macauley Locke, et al.
Published: (2021-12-01)

Computational Drug Design against Ebola Virus Targeting Viral Matrix Protein VP30
by: Arthi Venkatesan, et al.
Published: (2019-11-01)

Evasion of the Interferon-Mediated Antiviral Response by Filoviruses
by: Washington B. Cárdenas
Published: (2010-01-01)

Ebola-Detect: A differential serodiagnostic assay for Ebola virus infections and surveillance in the presence of vaccine-induced antibodies
by: Supriya Ravichandran, et al.
Published: (2022-08-01)

Interferon-Induced HERC5 Inhibits Ebola Virus Particle Production and Is Antagonized by Ebola Glycoprotein
by: Ermela Paparisto, et al.
Published: (2021-09-01)

Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form
by: Sara Landeras-Bueno, et al.
Published: (2021-04-01)

Inhibition of MAVS Aggregation-Mediated Type-I Interferon Signaling by Foot-and-Mouth Disease Virus VP3
by: Pathum Ekanayaka, et al.
Published: (2021-09-01)

The Disruption of a Nuclear Export Signal in the C-Terminus of the Herpes Simplex Virus 1 Determinant of Pathogenicity UL24 Protein Leads to a Syncytial Plaque Phenotype
by: Carmen Elena Gonzalez, et al.
Published: (2023-09-01)

Chicken anemia virus VP1 negatively regulates type I interferon via targeting interferon regulatory factor 7 of the DNA-sensing pathway
by: Xuelan Liu, et al.
Published: (2023-01-01)

Nucleocytoplasmic Trafficking Perturbation Induced by Picornaviruses
by: Belén Lizcano-Perret, et al.
Published: (2021-06-01)

Ubiquitin Ligase SMURF2 Interacts with Filovirus VP40 and Promotes Egress of VP40 VLPs
by: Ariel Shepley-McTaggart, et al.
Published: (2021-02-01)

Effect of Interferon Gamma on Ebola Virus Infection of Primary Kupffer Cells and a Kupffer Cell Line
by: José A. Aguilar-Briseño, et al.
Published: (2023-10-01)

To be or not to be phosphorylated: understanding the role of Ebola virus nucleoprotein in the dynamic interplay with the transcriptional activator VP30 and the host phosphatase PP2A-B56
by: Lennart Kämper, et al.
Published: (2025-12-01)

Molecular docking study of anti-viral FDA-approved drugs as novel entry and replication Ebola viral inhibitors
by: Saghi Sepehri, et al.
Published: (2019-04-01)

Alphavirus Replicon DNA Vectors Expressing Ebola GP and VP40 Antigens Induce Humoral and Cellular Immune Responses in Mice
by: Shoufeng Ren, et al.
Published: (2018-01-01)

Functional insights of nucleocytoplasmic transport in plants
by: Kentaro eTamura, et al.
Published: (2014-04-01)

Major Virion Tegument Protein VP22 Targets Nuclear Matrix and Chromatin upon Entry into Cells during Productive Herpes Simplex Virus 1 Infection
by: Isabella Chi, et al.
Published: (2024-03-01)

Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion
by: Michelle L. Pleet, et al.
Published: (2019-05-01)

Plasma Proteomic Analysis Distinguishes Severity Outcomes of Human Ebola Virus Disease
by: Arthur Viodé, et al.
Published: (2022-06-01)

Enterovirus D68 VP3 Targets the Interferon Regulatory Factor 7 To Inhibit Type I Interferon Response
by: Jun Kang, et al.
Published: (2023-06-01)

tRNA Processing and Subcellular Trafficking Proteins Multitask in Pathways for Other RNAs
by: Anita K. Hopper, et al.
Published: (2019-02-01)

Host factor SMYD3 is recruited by Ebola virus nucleoprotein to facilitate viral mRNA transcription
by: Jingliang Chen, et al.
Published: (2019-01-01)

Nuclear envelope budding and its cellular functions
by: Katharina S. Keuenhof, et al.
Published: (2023-12-01)

The Epithelial Circumferential Actin Belt Regulates YAP/TAZ through Nucleocytoplasmic Shuttling of Merlin
by: Kana T. Furukawa, et al.
Published: (2017-08-01)

Development of Monoclonal Antibody to Specifically Recognize VP0 but Not VP4 and VP2 of Foot-and-Mouth Disease Virus
by: Sun Young Park, et al.
Published: (2022-12-01)

Treatment with Ad5-Porcine Interferon-α Attenuates Ebolavirus Disease in Pigs
by: Chandrika Senthilkumaran, et al.
Published: (2022-04-01)

Frontal VP & VA Shunts Versus post parietal VP &VA Shunts
by: A- Hadi Khalili, et al.
Published: (2005-04-01)

Development of a Novel, Highly Sensitive System for Evaluating Ebola Virus Particle Formation
by: Wakako Furuyama, et al.
Published: (2025-07-01)