Staphylococcus aureus Infection Initiates Hypoxia-Mediated Transforming Growth Factor-β1 Upregulation to Trigger Osteomyelitis

ABSTRACT Little is unknown about the regulatory mechanisms underlying the pathogenesis of osteomyelitis induced by Staphylococcus aureus. Hypoxia-inducible factor-1α (HIF-1α) and transforming growth factor β1 (TGF-β1) were both upregulated in S. aureus-infected MC3T3-E1 cells and osteomyelitis patie...

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Bibliographic Details

Published in:	mSystems
Main Authors:	Wei Zhang, Yiwei Lin, Yang Zong, Xin Ma, Chaolai Jiang, Haojie Shan, Wenyang Xia, Lifu Yin, Nan Wang, Lihui Zhou, Zubin Zhou, Xiaowei Yu
Format:	Article
Language:	English
Published:	American Society for Microbiology 2022-08-01
Subjects:	Staphylococcus aureus osteomyelitis hypoxia hypoxia-inducible factor-1α (HIF-1α) transforming growth factor-β1 (TGF-β1)
Online Access:	https://journals.asm.org/doi/10.1128/msystems.00380-22