Renessans Helps in Early Clearance of SARS-CoV-2: <i>In-Vivo</i> Activity of the Iodine Complex in <i>Rhesus macaque</i>
Iodine complexes have known antimicrobial properties along with reported <i>in-vitro</i> antiviral activity for several viruses. Renessans is one such product with iodine complexes and ascorbic acid. The present study was designed to determine its efficacy for SARS-CoV-2 in <i>Rhes...
| Published in: | Life |
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| Language: | English |
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MDPI AG
2022-09-01
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| Online Access: | https://www.mdpi.com/2075-1729/12/9/1424 |
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| author | Muhammad Nawaz Muhammad Adnan Ashraf Muhammad Asad Ali Muhammad Zubair Shabbir Muhammad Abu Bakr Shabbir Imran Altaf Sohail Raza Saira Rafique Sohail Hassan Nageen Sardar Adnan Mehmood Muhammad Waqar Aziz Sehar Fazal Muhammad Tahir Khan Hafiz Muhammad Moavia Atique Ali Asif Zia Ullah Mubashir Iqbal Talha Imtiaz Muhammad Anwar Nadia Mukhtar Tahir Yaqub |
| author_facet | Muhammad Nawaz Muhammad Adnan Ashraf Muhammad Asad Ali Muhammad Zubair Shabbir Muhammad Abu Bakr Shabbir Imran Altaf Sohail Raza Saira Rafique Sohail Hassan Nageen Sardar Adnan Mehmood Muhammad Waqar Aziz Sehar Fazal Muhammad Tahir Khan Hafiz Muhammad Moavia Atique Ali Asif Zia Ullah Mubashir Iqbal Talha Imtiaz Muhammad Anwar Nadia Mukhtar Tahir Yaqub |
| author_sort | Muhammad Nawaz |
| collection | DOAJ |
| container_title | Life |
| description | Iodine complexes have known antimicrobial properties along with reported <i>in-vitro</i> antiviral activity for several viruses. Renessans is one such product with iodine complexes and ascorbic acid. The present study was designed to determine its efficacy for SARS-CoV-2 in <i>Rhesus macaque</i>. <i>Rhesus macaque</i> were assigned to: A) prophylactic group (n = 3), (B) treatment group (n = 3), (C) infection control group (n = 4), and (D) negative control group (n = 4). Groups A, B, and C were challenged with 2 × 10<sup>6</sup> TCID of SARS-CoV-2. The prophylactic group (A) was administered Renessans from 5 days before infection till 8 days postinfection (DPI). The treatment group (B) was administered Renessans from 3 till 8 DPI. Group C was administered water-insoluble fractions only. Nasal swabs from all monkeys of groups A, B, and C remained positive for SARS-CoV-2 till 2 and 7 DPI, while the swabs became negative for groups A and B at 14 DPI. Likewise, fecal matter of monkeys in group A returned negative results during the experiment, while that of group B had significantly decreased viral load (10<sup>1.5</sup> genome copies/mL) compared to group C (10<sup>3</sup> genome copies/mL). Hence, it is concluded that Renessans has <i>in-vivo</i> SARS-CoV-2 activity and may result in early clearance of SARS-CoV-2. |
| format | Article |
| id | doaj-art-e6d3505f129e44d4bef44b034906fde7 |
| institution | Directory of Open Access Journals |
| issn | 2075-1729 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-e6d3505f129e44d4bef44b034906fde72025-08-19T22:34:29ZengMDPI AGLife2075-17292022-09-01129142410.3390/life12091424Renessans Helps in Early Clearance of SARS-CoV-2: <i>In-Vivo</i> Activity of the Iodine Complex in <i>Rhesus macaque</i>Muhammad Nawaz0Muhammad Adnan Ashraf1Muhammad Asad Ali2Muhammad Zubair Shabbir3Muhammad Abu Bakr Shabbir4Imran Altaf5Sohail Raza6Saira Rafique7Sohail Hassan8Nageen Sardar9Adnan Mehmood10Muhammad Waqar Aziz11Sehar Fazal12Muhammad Tahir Khan13Hafiz Muhammad Moavia Atique14Ali Asif15Zia Ullah16Mubashir Iqbal17Talha Imtiaz18Muhammad Anwar19Nadia Mukhtar20Tahir Yaqub21Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanPet Centre, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanInstitute of Microbiology, University of Veterinary and Animal Sciences, Lahore 54000, PakistanIodine complexes have known antimicrobial properties along with reported <i>in-vitro</i> antiviral activity for several viruses. Renessans is one such product with iodine complexes and ascorbic acid. The present study was designed to determine its efficacy for SARS-CoV-2 in <i>Rhesus macaque</i>. <i>Rhesus macaque</i> were assigned to: A) prophylactic group (n = 3), (B) treatment group (n = 3), (C) infection control group (n = 4), and (D) negative control group (n = 4). Groups A, B, and C were challenged with 2 × 10<sup>6</sup> TCID of SARS-CoV-2. The prophylactic group (A) was administered Renessans from 5 days before infection till 8 days postinfection (DPI). The treatment group (B) was administered Renessans from 3 till 8 DPI. Group C was administered water-insoluble fractions only. Nasal swabs from all monkeys of groups A, B, and C remained positive for SARS-CoV-2 till 2 and 7 DPI, while the swabs became negative for groups A and B at 14 DPI. Likewise, fecal matter of monkeys in group A returned negative results during the experiment, while that of group B had significantly decreased viral load (10<sup>1.5</sup> genome copies/mL) compared to group C (10<sup>3</sup> genome copies/mL). Hence, it is concluded that Renessans has <i>in-vivo</i> SARS-CoV-2 activity and may result in early clearance of SARS-CoV-2.https://www.mdpi.com/2075-1729/12/9/1424iodine compoundantiviralCOVID-19coronavirusanimal trial |
| spellingShingle | Muhammad Nawaz Muhammad Adnan Ashraf Muhammad Asad Ali Muhammad Zubair Shabbir Muhammad Abu Bakr Shabbir Imran Altaf Sohail Raza Saira Rafique Sohail Hassan Nageen Sardar Adnan Mehmood Muhammad Waqar Aziz Sehar Fazal Muhammad Tahir Khan Hafiz Muhammad Moavia Atique Ali Asif Zia Ullah Mubashir Iqbal Talha Imtiaz Muhammad Anwar Nadia Mukhtar Tahir Yaqub Renessans Helps in Early Clearance of SARS-CoV-2: <i>In-Vivo</i> Activity of the Iodine Complex in <i>Rhesus macaque</i> iodine compound antiviral COVID-19 coronavirus animal trial |
| title | Renessans Helps in Early Clearance of SARS-CoV-2: <i>In-Vivo</i> Activity of the Iodine Complex in <i>Rhesus macaque</i> |
| title_full | Renessans Helps in Early Clearance of SARS-CoV-2: <i>In-Vivo</i> Activity of the Iodine Complex in <i>Rhesus macaque</i> |
| title_fullStr | Renessans Helps in Early Clearance of SARS-CoV-2: <i>In-Vivo</i> Activity of the Iodine Complex in <i>Rhesus macaque</i> |
| title_full_unstemmed | Renessans Helps in Early Clearance of SARS-CoV-2: <i>In-Vivo</i> Activity of the Iodine Complex in <i>Rhesus macaque</i> |
| title_short | Renessans Helps in Early Clearance of SARS-CoV-2: <i>In-Vivo</i> Activity of the Iodine Complex in <i>Rhesus macaque</i> |
| title_sort | renessans helps in early clearance of sars cov 2 i in vivo i activity of the iodine complex in i rhesus macaque i |
| topic | iodine compound antiviral COVID-19 coronavirus animal trial |
| url | https://www.mdpi.com/2075-1729/12/9/1424 |
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