Inhibiting neuronal AC1 for treating anxiety and headache in the animal model of migraine
Summary: Migraines are a common medical condition. From a basic science point of view, the central mechanism for migraine and headache is largely unknown. In the present study, we demonstrate that cortical excitatory transmission is significantly enhanced in the anterior cingulate cortex (ACC)—a bra...
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Elsevier
2023-06-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223008672 |
| _version_ | 1851927440533749760 |
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| author | Ren-Hao Liu Mingjie Zhang Man Xue Tao Wang Jing-Shan Lu Xu-Hui Li Yu-Xin Chen Kexin Fan Wantong Shi Si-Bo Zhou Qi-Yu Chen Li Kang Qian Song Shengyuan Yu Min Zhuo |
| author_facet | Ren-Hao Liu Mingjie Zhang Man Xue Tao Wang Jing-Shan Lu Xu-Hui Li Yu-Xin Chen Kexin Fan Wantong Shi Si-Bo Zhou Qi-Yu Chen Li Kang Qian Song Shengyuan Yu Min Zhuo |
| author_sort | Ren-Hao Liu |
| collection | DOAJ |
| container_title | iScience |
| description | Summary: Migraines are a common medical condition. From a basic science point of view, the central mechanism for migraine and headache is largely unknown. In the present study, we demonstrate that cortical excitatory transmission is significantly enhanced in the anterior cingulate cortex (ACC)—a brain region which is critical for pain perception. Biochemical studies found that the phosphorylation levels of both the NMDA receptor GluN2B and AMPA receptor GluA1 were enhanced in ACC of migraine rats. Both the presynaptic release of glutamate and postsynaptic responses of AMPA receptors and NMDA receptors were enhanced. Synaptic long-term potentiation (LTP) was occluded. Furthermore, behavioral anxiety and nociceptive responses were increased, which were reversed by application of AC1 inhibitor NB001 within ACC. Our results provide strong evidence that cortical LTPs contribute to migraine-related pain and anxiety. Drugs that inhibit cortical excitation such as NB001 may serve as potential medicines for treating migraine in the future. |
| format | Article |
| id | doaj-art-e6e006e6d4214ca0ada79fc211dfa706 |
| institution | Directory of Open Access Journals |
| issn | 2589-0042 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| spelling | doaj-art-e6e006e6d4214ca0ada79fc211dfa7062025-08-19T21:56:02ZengElsevieriScience2589-00422023-06-0126610679010.1016/j.isci.2023.106790Inhibiting neuronal AC1 for treating anxiety and headache in the animal model of migraineRen-Hao Liu0Mingjie Zhang1Man Xue2Tao Wang3Jing-Shan Lu4Xu-Hui Li5Yu-Xin Chen6Kexin Fan7Wantong Shi8Si-Bo Zhou9Qi-Yu Chen10Li Kang11Qian Song12Shengyuan Yu13Min Zhuo14Institute of Brain Research, Qingdao International Academician Park, Qingdao 266000, China; Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, ChinaDepartment of Neurology, the First Medical Centre, Chinese PLA General Hospital, Beijing 100853, ChinaInstitute of Brain Research, Qingdao International Academician Park, Qingdao 266000, China; Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaDepartment of Neurology, the First Medical Centre, Chinese PLA General Hospital, Beijing 100853, ChinaInstitute of Brain Research, Qingdao International Academician Park, Qingdao 266000, China; Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaInstitute of Brain Research, Qingdao International Academician Park, Qingdao 266000, China; Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaInstitute of Brain Research, Qingdao International Academician Park, Qingdao 266000, China; Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaInstitute of Brain Research, Qingdao International Academician Park, Qingdao 266000, China; Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaInstitute of Brain Research, Qingdao International Academician Park, Qingdao 266000, China; Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaInstitute of Brain Research, Qingdao International Academician Park, Qingdao 266000, China; Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaInstitute of Brain Research, Qingdao International Academician Park, Qingdao 266000, China; Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaDepartment of Neurology, the First Medical Centre, Chinese PLA General Hospital, Beijing 100853, ChinaNeuroscience Research Center, Institute of Mitochondrial Biology and Medicine, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Core Facilities Sharing Platform, Xi’an Jiaotong University, Xi’an 710049, ChinaDepartment of Neurology, the First Medical Centre, Chinese PLA General Hospital, Beijing 100853, China; Corresponding authorInstitute of Brain Research, Qingdao International Academician Park, Qingdao 266000, China; Center for Neuron and Disease, Frontier Institutes of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China; Corresponding authorSummary: Migraines are a common medical condition. From a basic science point of view, the central mechanism for migraine and headache is largely unknown. In the present study, we demonstrate that cortical excitatory transmission is significantly enhanced in the anterior cingulate cortex (ACC)—a brain region which is critical for pain perception. Biochemical studies found that the phosphorylation levels of both the NMDA receptor GluN2B and AMPA receptor GluA1 were enhanced in ACC of migraine rats. Both the presynaptic release of glutamate and postsynaptic responses of AMPA receptors and NMDA receptors were enhanced. Synaptic long-term potentiation (LTP) was occluded. Furthermore, behavioral anxiety and nociceptive responses were increased, which were reversed by application of AC1 inhibitor NB001 within ACC. Our results provide strong evidence that cortical LTPs contribute to migraine-related pain and anxiety. Drugs that inhibit cortical excitation such as NB001 may serve as potential medicines for treating migraine in the future.http://www.sciencedirect.com/science/article/pii/S2589004223008672PsychiatryPharmacologyMolecular neuroscience |
| spellingShingle | Ren-Hao Liu Mingjie Zhang Man Xue Tao Wang Jing-Shan Lu Xu-Hui Li Yu-Xin Chen Kexin Fan Wantong Shi Si-Bo Zhou Qi-Yu Chen Li Kang Qian Song Shengyuan Yu Min Zhuo Inhibiting neuronal AC1 for treating anxiety and headache in the animal model of migraine Psychiatry Pharmacology Molecular neuroscience |
| title | Inhibiting neuronal AC1 for treating anxiety and headache in the animal model of migraine |
| title_full | Inhibiting neuronal AC1 for treating anxiety and headache in the animal model of migraine |
| title_fullStr | Inhibiting neuronal AC1 for treating anxiety and headache in the animal model of migraine |
| title_full_unstemmed | Inhibiting neuronal AC1 for treating anxiety and headache in the animal model of migraine |
| title_short | Inhibiting neuronal AC1 for treating anxiety and headache in the animal model of migraine |
| title_sort | inhibiting neuronal ac1 for treating anxiety and headache in the animal model of migraine |
| topic | Psychiatry Pharmacology Molecular neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223008672 |
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