Pharmacology, Physiology and Genetics of the Neuropeptide S System
The Neuropeptide S (NPS) system is a rather ‘young’ transmitter system that was discovered and functionally described less than 20 years ago. This review highlights the progress that has been made in elucidating its pharmacology, anatomical distribution, and functional involvement in a variety of ph...
| الحاوية / القاعدة: | Pharmaceuticals |
|---|---|
| المؤلفون الرئيسيون: | , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
MDPI AG
2021-04-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://www.mdpi.com/1424-8247/14/5/401 |
| _version_ | 1850091646181441536 |
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| author | Rainer K. Reinscheid Chiara Ruzza |
| author_facet | Rainer K. Reinscheid Chiara Ruzza |
| author_sort | Rainer K. Reinscheid |
| collection | DOAJ |
| container_title | Pharmaceuticals |
| description | The Neuropeptide S (NPS) system is a rather ‘young’ transmitter system that was discovered and functionally described less than 20 years ago. This review highlights the progress that has been made in elucidating its pharmacology, anatomical distribution, and functional involvement in a variety of physiological effects, including behavior and immune functions. Early on, genetic variations of the human NPS receptor (NPSR1) have attracted attention and we summarize current hypotheses of genetic linkage with disease and human behaviors. Finally, we review the therapeutic potential of future drugs modulating NPS signaling. This review serves as an introduction to the broad collection of original research papers and reviews from experts in the field that are presented in this Special Issue. |
| format | Article |
| id | doaj-art-e6e7fda1ed8046e8bbc35d8ac0f08d7d |
| institution | Directory of Open Access Journals |
| issn | 1424-8247 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-e6e7fda1ed8046e8bbc35d8ac0f08d7d2025-08-20T00:08:40ZengMDPI AGPharmaceuticals1424-82472021-04-0114540110.3390/ph14050401Pharmacology, Physiology and Genetics of the Neuropeptide S SystemRainer K. Reinscheid0Chiara Ruzza1Institute of Pharmacology & Toxicology, University Hospital Jena, Friedrich-Schiller University, 07747 Jena, GermanyDepartment of Neuroscience and Rehabilitation and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, 44121 Ferrara, ItalyThe Neuropeptide S (NPS) system is a rather ‘young’ transmitter system that was discovered and functionally described less than 20 years ago. This review highlights the progress that has been made in elucidating its pharmacology, anatomical distribution, and functional involvement in a variety of physiological effects, including behavior and immune functions. Early on, genetic variations of the human NPS receptor (NPSR1) have attracted attention and we summarize current hypotheses of genetic linkage with disease and human behaviors. Finally, we review the therapeutic potential of future drugs modulating NPS signaling. This review serves as an introduction to the broad collection of original research papers and reviews from experts in the field that are presented in this Special Issue.https://www.mdpi.com/1424-8247/14/5/401transmitterGPCRbrainstemanxietymemorygenetic variation |
| spellingShingle | Rainer K. Reinscheid Chiara Ruzza Pharmacology, Physiology and Genetics of the Neuropeptide S System transmitter GPCR brainstem anxiety memory genetic variation |
| title | Pharmacology, Physiology and Genetics of the Neuropeptide S System |
| title_full | Pharmacology, Physiology and Genetics of the Neuropeptide S System |
| title_fullStr | Pharmacology, Physiology and Genetics of the Neuropeptide S System |
| title_full_unstemmed | Pharmacology, Physiology and Genetics of the Neuropeptide S System |
| title_short | Pharmacology, Physiology and Genetics of the Neuropeptide S System |
| title_sort | pharmacology physiology and genetics of the neuropeptide s system |
| topic | transmitter GPCR brainstem anxiety memory genetic variation |
| url | https://www.mdpi.com/1424-8247/14/5/401 |
| work_keys_str_mv | AT rainerkreinscheid pharmacologyphysiologyandgeneticsoftheneuropeptidessystem AT chiararuzza pharmacologyphysiologyandgeneticsoftheneuropeptidessystem |