Pharmacology, Physiology and Genetics of the Neuropeptide S System

The Neuropeptide S (NPS) system is a rather ‘young’ transmitter system that was discovered and functionally described less than 20 years ago. This review highlights the progress that has been made in elucidating its pharmacology, anatomical distribution, and functional involvement in a variety of ph...

Full description

Bibliographic Details
Published in:	Pharmaceuticals
Main Authors:	Rainer K. Reinscheid, Chiara Ruzza
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Subjects:	transmitter GPCR brainstem anxiety memory genetic variation
Online Access:	https://www.mdpi.com/1424-8247/14/5/401

Similar Items

Neuropeptides and pharmacology
by: Tamas Bartfai, et al.
Published: (2024-08-01)

Brain RFamide Neuropeptides in Stress-Related Psychopathologies
by: Anita Kovács, et al.
Published: (2024-06-01)

Pharmacological characterization of the neuropeptide F receptor (NPFR) in Macrobrachium rosenbergii
by: Yue-Miao Yu, et al.
Published: (2025-12-01)

Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling
by: Sydney A. Pascetta, et al.
Published: (2023-06-01)

Editorial: The role of GPCRs in obesity
by: Chunye Zhang, et al.
Published: (2024-04-01)

Orexins/Hypocretins and Cancer: A Neuropeptide as Emerging Target
by: Couvineau Alain, et al.
Published: (2021-08-01)

Pro- and Anti-Inflammatory Neuropeptides and Glia: The Balance Between Neuroprotection and Neuroinflammation
by: Eli J. Futran-Sheinberg, et al.
Published: (2025-09-01)

Global analysis of neuropeptide receptor conservation across phylum Nematoda
by: Luca Golinelli, et al.
Published: (2024-10-01)

Four decades of research on Viktor Mutt’s neuropeptides with focus on galanin
by: Tomas Hökfelt, et al.
Published: (2024-08-01)

Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells
by: David Moreno Delgado, et al.
Published: (2017-06-01)

Evolution of neuropeptide Y/RFamide-like receptors in nematodes
by: Franziska Reinhardt, et al.
Published: (2024-07-01)

Exploring pUS27: Insights into Its Role in HCMV Pathogenesis and Potential for Antiviral Strategies
by: Gage M. Connors, et al.
Published: (2025-10-01)

Large-scale deorphanization of Nematostella vectensis neuropeptide G protein-coupled receptors supports the independent expansion of bilaterian and cnidarian peptidergic systems
by: Daniel Thiel, et al.
Published: (2024-05-01)

The Dynamics of the Neuropeptide Y Receptor Type 1 Investigated by Solid-State NMR and Molecular Dynamics Simulation
by: Alexander Vogel, et al.
Published: (2020-11-01)

An Insight into GPCR and G-Proteins as Cancer Drivers
by: Preeti Kumari Chaudhary, et al.
Published: (2021-11-01)

Unveiling a novel memory center in human brain: neurochemical identification of the nucleus incertus, a key pontine locus implicated in stress and neuropathology
by: Camila de Ávila, et al.
Published: (2024-07-01)

FLIPs: Novel genetically encoded biosensors for polarization microscopy
by: Miclea Paul, et al.
Published: (2024-01-01)

Unusually persistent Gαi-signaling of the neuropeptide Y2 receptor depletes cellular Gi/o pools and leads to a Gi-refractory state
by: Isabelle Ziffert, et al.
Published: (2020-03-01)

A fluorescently-tagged tick kinin neuropeptide triggers peristalsis and labels tick midgut muscles
by: Jonathan R. Hernandez, et al.
Published: (2024-05-01)

Molecular and genetic mechanisms of physiological adaptations in high- altitude natives Molecular and genetic mechanisms of physiological adaptations in high- altitude natives
by: Abolfazl Khademi, et al.
Published: (2019-12-01)

Charge Movements and Conformational Changes: Biophysical Properties and Physiology of Voltage-Dependent GPCRs
by: Andreas Rinne, et al.
Published: (2024-12-01)

Neuropeptide S-Mediated Modulation of Prepulse Inhibition Depends on Age, Gender, Stimulus-Timing, and Attention
by: Wei Si, et al.
Published: (2021-05-01)

Role of brain cholecystokinin in neuronal homeostasis: rediscovering novel functions of an old neuropeptide
by: Santiago J. Ballaz
Published: (2025-08-01)

Auditory brainstem functioning in individuals with misophonia
by: Sajana Aryal, et al.
Published: (2023-07-01)

Exploring GPR120/FFAR4 pharmacology: Unveiling novel therapeutic avenues through molecular signaling pathways for Alzheimer's disease intervention
by: Priyadharshini Gogu, et al.
Published: (2025-10-01)

A Review of Miniature Radio Transmitters for Wildlife Tracking
by: Sivan Toledo
Published: (2025-01-01)

Detection of antigen interactions ex vivo by proximity ligation assay: endogenous dopamine D2-adenosine A2A receptor complexes in the striatum
by: Pierre Trifilieff, et al.
Published: (2011-08-01)

G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L
by: Tao Zhang, et al.
Published: (2015-03-01)

Radiotracers for the Central Serotoninergic System
by: Reynald Mangeant, et al.
Published: (2022-05-01)

Novel Pharmacology Following Heteromerization of the Angiotensin II Type 2 Receptor and the Bradykinin Type 2 Receptor
by: Elizabeth K. M. Johnstone, et al.
Published: (2022-05-01)

The Inhibitory Receptor GPR56 (<i>Adgrg1</i>) Is Specifically Expressed by Tissue-Resident Memory T Cells in Mice But Dispensable for Their Differentiation and Function In Vivo
by: Cheng-Chih Hsiao, et al.
Published: (2021-10-01)

G-Protein-Coupled Receptor (GPCR) Signaling and Pharmacology in Metabolism: Physiology, Mechanisms, and Therapeutic Potential
by: Yun Yeong Cho, et al.
Published: (2025-02-01)

Proton-Sensing GPCRs in Health and Disease
by: Marco Sisignano, et al.
Published: (2021-08-01)

Ligands and Beyond: Mechanosensitive Adhesion GPCRs
by: Hsi-Hsien Lin, et al.
Published: (2022-02-01)

Cryo-EM structure of the endothelin-1-ETB-Gi complex
by: Fumiya K Sano, et al.
Published: (2023-04-01)

GPCR heterodimerization in the reproductive system: functional regulation and implication for biodiversity
by: Honoo eSatake, et al.
Published: (2013-08-01)

The value of computed tomography perfusion deficit volumes in acute isolated brainstem infarction
by: Pengjun Chen, et al.
Published: (2023-10-01)

Key Challenges and Future Directions When Running Auditory Brainstem Response (ABR) Research Protocols with Newborns: A Music and Language EEG Feasibility Study
by: Efthymios Papatzikis, et al.
Published: (2021-11-01)

Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors
by: Christopher A Natale, et al.
Published: (2016-04-01)

Genetic and neuronal regulation of sleep by neuropeptide VF
by: Daniel A Lee, et al.
Published: (2017-11-01)