Flaming the fight against cancer cells: the role of microRNA-93

• 出版年: Cancer Cell International
• 主要な著者: Milad Ashrafizadeh, Masoud Najafi, Reza Mohammadinejad, Tahereh Farkhondeh, Saeed Samarghandian
• フォーマット: 論文
• 言語: 英語
• 出版事項: BMC 2020-06-01
• 主題: Cancer therapy; MicroRNA; Oncogenesis; Oncosuppressor; Signaling pathway
• オンライン･アクセス: http://link.springer.com/article/10.1186/s12935-020-01349-x

Abstract There have been attempts to develop novel anti-tumor drugs in cancer therapy. Although satisfying results have been observed at a consequence of application of chemotherapeutic agents, the cancer cells are capable of making resistance into these agents. This has forced scientists into genetic manipulation as genetic alterations are responsible for generation of a high number of cancer cells. MicroRNAs (miRs) are endogenous, short non-coding RNAs that affect target genes at the post-transcriptional level. Increasing evidence reveals the potential role of miRs in regulation of biological processes including angiogenesis, metabolism, cell proliferation, cell division, and cell differentiation. Abnormal expression of miRs is associated with development of a number of pathologic events, particularly cancer. MiR-93 plays a significant role in both physiological and pathological mechanisms. At the present review, we show how this miR dually affects the proliferation and invasion of cancer cells. Besides, we elucidate the oncogenesis or oncosuppressor function of miR-93.