| الملخص: | Key Clinical Message Ocular brucellosis is a potential cause of endogenous endophthalmitis in endemic areas, which can be associated with sight‐threatening complications. Abstract To report a patient with unusual fulminant endogenous endophthalmitis due to Brucella melitensis. A 25‐year‐old woman with a history of fever and right shoulder pain from 4 months ago and a positive Wright test presented with acute panuveitis in her right eye. All laboratory tests were unremarkable except for the positive polymerase chain reaction (PCR) test of the vitreous sample for B. melitensis. Despite the therapeutic efforts, including multiple vitreoretinal surgeries, and intravitreal and systemic antibiotics, the patient's final follow‐up examination after 6 months revealed hand motion vision, hypotonia, and pre‐phthisis bulbi status. The fellow eye was entirely normal. Brucella endogenous endophthalmitis can be fulminant and result in poor visual outcomes. It is suggested to consider ocular brucellosis as a potential cause of endogenous endophthalmitis in endemic areas.
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