Gene coexpression networks reveal a broad role for lncRNAs in inflammatory bowel disease

The role of long noncoding RNAs (lncRNAs) in disease is incompletely understood, but their regulation of inflammation is increasingly appreciated. We addressed the extent of lncRNA involvement in inflammatory bowel disease (IBD) using biopsy-derived RNA-sequencing data from a large cohort of deeply...

Full description

Bibliographic Details
Published in:	JCI Insight
Main Authors:	John L. Johnson, Davit Sargsyan, Eric M. Neiman, Amy Hart, Aleksandar Stojmirovic, Roman Kosoy, Haritz Irizar, Mayte Suárez-Fariñas, Won-Min Song, Carmen Argmann, Stefan Avey, Liraz Shmuel-Galia, Tim Vierbuchen, Gerold Bongers, Yu Sun, Leonard Edelstein, Jacqueline Perrigoue, Jennifer E. Towne, Aisling O’Hara Hall, Katherine A. Fitzgerald, Kasper Hoebe
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2024-02-01
Subjects:	Gastroenterology Immunology
Online Access:	https://doi.org/10.1172/jci.insight.168988

Similar Items

Ensuring the Future Pool of Gastroenterologists in the United Kingdom Is Imperative
by: Hareesha Rishab Bharadwaj, et al.
Published: (2024-12-01)

How to Revitalize the Abdominal Ultrasonography Education Program
by: Beom Kyung Kim, et al.
Published: (2019-02-01)

Prospective observational study and mechanistic evidence showing lipolysis of circulating triglycerides worsens hypertriglyceridemic acute pancreatitis
by: Prasad Rajalingamgari, et al.
Published: (2025-01-01)

DRA involvement in linaclotide-stimulated bicarbonate secretion during loss of CFTR function
by: Jessica B. Sarthi, et al.
Published: (2024-07-01)

Human intestinal organoids from Cronkhite-Canada syndrome patients reveal link between serotonin and proliferation
by: Victoria Poplaski, et al.
Published: (2023-11-01)

Metabolic shifts in tryptophan pathways during acute pancreatitis infections
by: Daosheng Wang, et al.
Published: (2025-03-01)

Intestinal transit-amplifying cells require METTL3 for growth factor signaling and cell survival
by: Charles H. Danan, et al.
Published: (2023-12-01)

Region-specific Wnt signaling responses promote gastric polyp formation in patients with familial adenomatous polyposis
by: Kevin P. McGowan, et al.
Published: (2023-12-01)

Circular RNA Cdr1as inhibits proliferation and delays injury-induced regeneration of the intestinal epithelium
by: Hee Kyoung Chung, et al.
Published: (2024-02-01)

Human colonic EVs induce murine enteric neuroplasticity via the lncRNA GAS5/miR-23/NMDA NR2B axis
by: QiQi Zhou, et al.
Published: (2025-03-01)

TWIST1+FAP+ fibroblasts in the pathogenesis of intestinal fibrosis in Crohn’s disease
by: Yao Zhang, et al.
Published: (2024-09-01)

Dietary carbohydrates regulate intestinal colonization and dissemination of Klebsiella pneumoniae
by: Aaron L. Hecht, et al.
Published: (2024-05-01)

Claudin-2 protects against colitis-associated cancer by promoting colitis-associated mucosal healing
by: Rizwan Ahmad, et al.
Published: (2023-12-01)

First Russian Gastroenterology Olympiad
by: V. T. Ivashkin, et al.
Published: (2023-05-01)

Patient-derived enteroids provide a platform for the development of therapeutic approaches in microvillus inclusion disease
by: Meri Kalashyan, et al.
Published: (2023-10-01)

Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis
by: Efren A. Reyes, et al.
Published: (2023-10-01)

The epithelial-specific ER stress sensor ERN2/IRE1β enables host-microbiota crosstalk to affect colon goblet cell development
by: Michael J. Grey, et al.
Published: (2022-09-01)

CLUH functions as a negative regulator of inflammation in human macrophages and determines ulcerative colitis pathogenesis
by: Shaziya Khan, et al.
Published: (2023-06-01)

SELENOP modifies sporadic colorectal carcinogenesis and WNT signaling activity through LRP5/6 interactions
by: Jennifer M. Pilat, et al.
Published: (2023-07-01)

Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure
by: Jing Ma, et al.
Published: (2022-07-01)

Long noncoding RNA uc.230/CUG-binding protein 1 axis sustains intestinal epithelial homeostasis and response to tissue injury
by: Ting-Xi Yu, et al.
Published: (2022-10-01)

Secondary bile acids mediate high-fat diet–induced upregulation of R-spondin 3 and intestinal epithelial proliferation
by: Ji-Yao Li, et al.
Published: (2022-10-01)

Cell-autonomous retinoic acid receptor signaling has stage-specific effects on mouse enteric nervous system
by: Tao Gao, et al.
Published: (2021-05-01)

Ameliorating effects and mechanisms of transcutaneous auricular vagal nerve stimulation on abdominal pain and constipation
by: Xiaodan Shi, et al.
Published: (2021-07-01)

Mucosal transcriptomics highlight lncRNAs implicated in ulcerative colitis, Crohn’s disease, and celiac disease
by: Tzipi Braun, et al.
Published: (2023-07-01)

Hematopoietic progenitor kinase 1 inhibits the development and progression of pancreatic intraepithelial neoplasia
by: Hua Wang, et al.
Published: (2023-06-01)

A Shigella species variant is causally linked to intractable functional constipation
by: Xin Chen, et al.
Published: (2022-07-01)

NLRP12 downregulates the Wnt/β-catenin pathway via interaction with STK38 to suppress colorectal cancer
by: Shahanshah Khan, et al.
Published: (2023-10-01)

A case report concerning the importance of the patients’ symptoms and clinical findings in the management of patients
by: Bodil Ohlsson
Published: (2010-01-01)

Human CD4+CD8α+ Tregs induced by Faecalibacterium prausnitzii protect against intestinal inflammation
by: Sothea Touch, et al.
Published: (2022-06-01)

Bacterial cancer therapy in autochthonous colorectal cancer affects tumor growth and metabolic landscape
by: Gillian M. Mackie, et al.
Published: (2021-12-01)

UNC45A deficiency causes microvillus inclusion disease–like phenotype by impairing myosin VB–dependent apical trafficking
by: Rémi Duclaux-Loras, et al.
Published: (2022-05-01)

Efficacy of anti-TNF dosing interval lengthening in adolescents and young adults with inflammatory bowel disease in sustained remission (FREE-study): protocol for a partially randomized patient preference trial
by: Yu Minhao
Published: (2022-02-01)

When hiccups mean something more than just a nuisance: A rare presentation of pyogenic liver abscess
by: Muaaz Masood, et al.
Published: (2021-07-01)

Polybromo 1/vimentin axis dictates tumor grade, epithelial-mesenchymal transition, and metastasis in pancreatic cancer
by: Munenori Kawai, et al.
Published: (2025-06-01)

Clinical evidence for independent regulation of vitamin D by intestinal CYP24A1. Reply.
by: Michaela A.A. Fuchs, et al.
Published: (2025-04-01)

LIN28B-mediated PI3K/AKT pathway activation promotes metastasis in colorectal cancer models
by: Alice E. Shin, et al.
Published: (2025-04-01)

MOGAT3-mediated DAG accumulation drives acquired resistance to anti-BRAF/anti-EGFR therapy in BRAFV600E-mutant metastatic colorectal cancer
by: Jiawei Wang, et al.
Published: (2024-12-01)

Fusobacterium nucleatum promotes colorectal cancer through neogenesis of tumor stem cells
by: Qinying Wang, et al.
Published: (2025-02-01)

Activation of intestinal endogenous retroviruses by alcohol exacerbates liver disease
by: Noemí Cabré, et al.
Published: (2025-07-01)