Thiol-Epoxy Click Chemistry: The Synthesis of Vicinal Amino Alcohols Containing a 1,2,4-Triazole Ring

As examples of “Click Chemistry”, the reaction of 1-(oxiran-2-ylmethyl)piperidine with several 1,2,4-triazoles derivatives was studied. As a result, the reaction shows that the oxirane ring opens regiospecifically, according to Krasusky’s rule, without using a catalyst. The basic nitrogen present in...

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Bibliographic Details
Published in:Chemistry
Main Authors: Artyom V. Petrosyan, Astghik A. Shahkhatuni, Andranik M. Davinyan, Karine S. Avetisyan, Tariel V. Ghochikyan, Melanya A. Samvelyan, Valentine G. Nenajdenko, Armen S. Galstyan
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Subjects:
click chemistry
thiol-epoxy reaction
bis-1,2,4-triazole
vicinal amino alcohols
Krasusky’s rule
Online Access:https://www.mdpi.com/2624-8549/7/2/53
Description
Summary:As examples of “Click Chemistry”, the reaction of 1-(oxiran-2-ylmethyl)piperidine with several 1,2,4-triazoles derivatives was studied. As a result, the reaction shows that the oxirane ring opens regiospecifically, according to Krasusky’s rule, without using a catalyst. The basic nitrogen present in 1-(oxiran-2-ylmethyl)piperidine has a catalytic (anchimer) effect.
ISSN:2624-8549

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