NAT10‐mediated mRNA N4‐acetylcytidine modification promotes bladder cancer progression

Abstract Background Dysregulation of the epitranscriptome causes abnormal expression of oncogenes in the tumorigenic process. Previous studies have shown that NAT10 can regulate mRNA translation efficiency through RNA acetylation. However, the role of NAT10‐mediated acetylation modification in bladd...

Full description

Bibliographic Details
Published in:	Clinical and Translational Medicine
Main Authors:	Ganping Wang, Ming Zhang, Yiming Zhang, Yanqi Xie, Jiepeng Zou, Jianye Zhong, Zhijia Zheng, Xianghui Zhou, Yuhang Zheng, Binshen Chen, Chunxiao Liu
Format:	Article
Language:	English
Published:	Wiley 2022-05-01
Subjects:	bladder cancer mRNA N4‐acetylcytidine NAT10
Online Access:	https://doi.org/10.1002/ctm2.738

Similar Items

NAT10 promotes gastric cancer progression by enhancing the N4-acetylcytidine modification of TNC mRNA
by: Yu Chen, et al.
Published: (2025-03-01)

NAT10 promotes ovarian cancer cell migration, invasion, and stemness via N4-acetylcytidine modification of CAPRIN1
by: Yang Song, et al.
Published: (2025-02-01)

The critical role of NAT10-mediated N4-acetylcytidine modification in tumor immunity
by: Chunhong Li, et al.
Published: (2025-10-01)

RNA N4‐acetylcytidine modification and its role in health and diseases
by: Qiang Wang, et al.
Published: (2025-01-01)

CircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA
by: Chunyu Zhang, et al.
Published: (2024-02-01)

NAT10 Maintains OGA mRNA Stability Through ac4C Modification in Regulating Oocyte Maturation
by: Jiayu Lin, et al.
Published: (2022-07-01)

Recent advances in the potential role of RNA N4-acetylcytidine in cancer progression
by: Shujun Zhang, et al.
Published: (2024-01-01)

Targeting NAT10 inhibits osteosarcoma progression via ATF4/ASNS-mediated asparagine biosynthesis
by: Yutong Zou, et al.
Published: (2024-09-01)

Targeting N4‐acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2‐mediated HMGB2 mRNA translation
by: Hailing Liu, et al.
Published: (2024-09-01)

NAT10‐mediated mRNA N4‐acetylcytidine modification of MDR1 and BCRP promotes breast cancer progression
by: Cui‐Cui Zhao, et al.
Published: (2024-04-01)

Amplification efficiency and cost analysis of MP-NAT and ID-NAT in blood samples
by: Ziyi HE, et al.
Published: (2023-04-01)

NAT10 mediated mRNA acetylation modification patterns associated with colon cancer progression and microsatellite status
by: Hailin Zhang, et al.
Published: (2023-12-01)

PCBP1/2 and TDP43 Function as NAT10 Adaptors to Mediate mRNA ac4C Formation in Mammalian Cells
by: Zhi‐Yan Jiang, et al.
Published: (2024-12-01)

Stacking-ac4C: an ensemble model using mixed features for identifying n4-acetylcytidine in mRNA
by: Li-Liang Lou, et al.
Published: (2023-11-01)

NAT10/ac4C/JunB facilitates TNBC malignant progression and immunosuppression by driving glycolysis addiction
by: Guozheng Li, et al.
Published: (2024-10-01)

Biological Function and Mechanism of NAT10 in Cancer
by: Yufeng Han, et al.
Published: (2025-02-01)

Recognition of mRNA N4 Acetylcytidine (ac4C) by Using Non-Deep vs. Deep Learning
by: Muhammad Shahid Iqbal, et al.
Published: (2022-01-01)

NAT10/ac4C/FOXP1 Promotes Malignant Progression and Facilitates Immunosuppression by Reprogramming Glycolytic Metabolism in Cervical Cancer
by: Xiaona Chen, et al.
Published: (2023-11-01)

N4‐Acetylcytidine Drives Glycolysis Addiction in Gastric Cancer via NAT10/SEPT9/HIF‐1α Positive Feedback Loop
by: Qingbin Yang, et al.
Published: (2023-08-01)

Studying polymorphic variants of the NAT2 gene (NAT2*5 and NAT2*7) in Nenets populations of Northern Siberia
by: Roza Pavlovna Tiis, et al.
Published: (2020-10-01)

ac4C-AFL: A high-precision identification of human mRNA N4-acetylcytidine sites based on adaptive feature representation learning
by: Nhat Truong Pham, et al.
Published: (2024-06-01)

DeepRNAac4C: a hybrid deep learning framework for RNA N4-acetylcytidine site prediction
by: Guohua Huang, et al.
Published: (2025-08-01)

Correction: DeepRNAac4C: a hybrid deep learning framework for RNA N4-acetylcytidine site prediction
by: Guohua Huang, et al.
Published: (2025-10-01)

STM-ac4C: a hybrid model for identification of N4-acetylcytidine (ac4C) in human mRNA based on selective kernel convolution, temporal convolutional network, and multi-head self-attention
by: Mengyue Yi, et al.
Published: (2024-05-01)

The role of isoniazid dosage and NAT2 gene polymorphism in the treatment of tuberculous meningitis
by: Yi Jian, et al.
Published: (2025-01-01)

N4‐Acetylcytidine‐Mediated CD2BP2‐DT Drives YBX1 Phase Separation to Stabilize CDK1 and Promote Breast Cancer Progression
by: Hongyu Wang, et al.
Published: (2025-04-01)

Acetylcytidine modification of DDX41 and ZNF746 by N-acetyltransferase 10 contributes to chemoresistance of melanoma
by: Li Wang, et al.
Published: (2024-08-01)

N-acetyltransferase 10 Promotes Cervical Cancer Progression Via N4-acetylation of SLC7A5 mRNA
by: Peili Liang, et al.
Published: (2025-02-01)

Compression force promotes the osteogenic differentiation of periodontal ligament stem cells by regulating NAT10-mediated ac4C modification of BMP2
by: Yan Feng, et al.
Published: (2024-12-01)

NAT yield in blood donors: An observational study
by: Ankit Sharma, et al.
Published: (2023-11-01)

MK-801-exposure induces increased translation efficiency and mRNA hyperacetylation of Grin2a in the mouse prefrontal cortex
by: Liting Xue, et al.
Published: (2024-12-01)

CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression
by: Yujun Shuai, et al.
Published: (2024-01-01)

NAT10 contributes to the progression of multiple myeloma through ac4C modification of GPR37
by: Haiyan Liu, et al.
Published: (2025-12-01)

NAT10 inhibits the pyroptosis of laryngeal squamous cell carcinoma through ac4C modification of ELANE mRNA
by: Yafang Yu, et al.
Published: (2025-05-01)

Aging increases susceptibility to liver fibrosis through enhanced NAT10-mediated ac4C modification of TGFβ1 mRNA
by: Xuyun Peng, et al.
Published: (2025-08-01)

RAST NA'T-I MEVLANA VE TAHLILİ
by: Mehmet Gönül
Published: (2012-12-01)

Influencing factors of the repeat reactive (RR) rates of minipools implicated in minipool(MP) nucleic acid testing(NAT) in Xiamen
by: Jiahuang WU, et al.
Published: (2023-07-01)

Characteristics of NAT+ blood donors screened for transfusion-transmitted infectious markers in Hainan
by: Yongli ZHANG, et al.
Published: (2024-07-01)

Confirmation of HBV infection of HBsAg-negative NAT suspicious sample from blood donors
by: Quanhui WANG, et al.
Published: (2023-12-01)

MEMAHAMI HADITS TENTANG LA’NAT MALAIKAT TERHADAP ISTRI YANG MENOLAK AJAKAN SUAMI
by: Sobari sutarip
Published: (2020-09-01)