The Fault in Our Astrocytes - cause or casualties of proteinopathies of ALS/FTD and other neurodegenerative diseases?

Many neurodegenerative diseases fall under the class of diseases known as proteinopathies, whereby the structure and localization of specific proteins become abnormal. These aberrant proteins often aggregate within cells which disrupts vital homeostatic and physiological cellular functions, ultimate...

Full description

Bibliographic Details
Published in:	Frontiers in Molecular Medicine
Main Authors:	Lynette M. Bustos, Rita Sattler
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Subjects:	astrocytes neurodegenaration proteinopathies ALS FTD Alzheimer's disease
Online Access:	https://www.frontiersin.org/articles/10.3389/fmmed.2023.1075805/full

Similar Items

In vivo diagnosis of TDP-43 proteinopathies: in search of biomarkers of clinical use
by: Juan I. López-Carbonero, et al.
Published: (2024-06-01)

Emerging Trends in the Field of Inflammation and Proteinopathy in ALS/FTD Spectrum Disorder
by: Fabiola De Marchi, et al.
Published: (2023-05-01)

Peripheral proteinopathy in neurodegenerative diseases
by: Bin Xu, et al.
Published: (2025-01-01)

Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits
by: R. Keating Godfrey, et al.
Published: (2023-10-01)

Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43A90V mutation display a mild reactive state and release polyP toxic to motoneurons
by: Fabiola Rojas, et al.
Published: (2023-07-01)

Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein
by: Zuzana Krejciova, et al.
Published: (2019-05-01)

Organotypic brain slice cultures to model neurodegenerative proteinopathies
by: C. L. Croft, et al.
Published: (2019-12-01)

Editorial: Prodromal stage of neurodegenerative proteinopathies: from bench to bedside
by: Bin Xu, et al.
Published: (2023-09-01)

Clinical, Cortical, Subcortical, and White Matter Features of Right Temporal Variant FTD
by: Jana Kleinerova, et al.
Published: (2024-08-01)

Drosophila melanogaster as a model to study autophagy in neurodegenerative diseases induced by proteinopathies
by: Stefania Santarelli, et al.
Published: (2023-05-01)

Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools
by: Paula Moyano, et al.
Published: (2023-07-01)

Cannabinoid CB2 Receptors in Neurodegenerative Proteinopathies: New Insights and Therapeutic Potential
by: Barbara Vuic, et al.
Published: (2022-11-01)

Astrocytes: Dissecting Their Diverse Roles in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
by: Chiara F. Valori, et al.
Published: (2023-05-01)

Exploring orphan GPCRs in neurodegenerative diseases
by: Devrim Öz-Arslan, et al.
Published: (2024-06-01)

Validity and Reliability of Clinical and Patient‐Reported Outcomes in Multisystem Proteinopathy 1
by: Lindsay N. Alfano, et al.
Published: (2025-07-01)

TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43
by: Juan M. Godoy-Corchuelo, et al.
Published: (2024-04-01)

Lipid Metabolic Alterations in the ALS–FTD Spectrum of Disorders
by: Juan Miguel Godoy-Corchuelo, et al.
Published: (2022-05-01)

Incidence and morphology of secondary TDP-43 proteinopathies: Part 2
by: Albert Acewicz, et al.
Published: (2023-07-01)

Incidence and morphology of secondary TDP-43 proteinopathies: Part 1
by: Albert Acewicz, et al.
Published: (2022-11-01)

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy
by: Julie C Necarsulmer, et al.
Published: (2023-10-01)

Readthrough isoform of aquaporin-4 (AQP4) as a therapeutic target for Alzheimer’s disease and other proteinopathies
by: Pablo Mohaupt, et al.
Published: (2023-10-01)

Mitochondrion-Dependent Cell Death in TDP-43 Proteinopathies
by: Chantal B. Lucini, et al.
Published: (2021-04-01)

Development and In Vitro Characterization of [<sup>3</sup>H]GMC-058 as Radioligand for Imaging Parkinsonian-Related Proteinopathies
by: Andrea Varrone, et al.
Published: (2025-06-01)

Linking Oxidative Stress and Proteinopathy in Alzheimer’s Disease
by: Chanchal Sharma, et al.
Published: (2021-07-01)

α-synuclein and tau: interactions, cross-seeding, and the redefinition of synucleinopathies as complex proteinopathies
by: Francisco J. Padilla-Godínez, et al.
Published: (2025-03-01)

Prion-like Spreading of Disease in TDP-43 Proteinopathies
by: Emma Pongrácová, et al.
Published: (2024-11-01)

Disease Mechanisms and Therapeutic Approaches in <i>C9orf72</i> ALS-FTD
by: Keith Mayl, et al.
Published: (2021-05-01)

Unraveling the Role of Proteinopathies in Parasitic Infections
by: Mikołaj Hurła, et al.
Published: (2025-03-01)

Plasma proteome profiling identifies changes associated to AD but not to FTD
by: R. Babapour Mofrad, et al.
Published: (2022-10-01)

Molecular Chaperones: A Double-Edged Sword in Neurodegenerative Diseases
by: Jessica Tittelmeier, et al.
Published: (2020-10-01)

The Molecular Clock and Neurodegenerative Disease: A Stressful Time
by: Bethany Carter, et al.
Published: (2021-03-01)

Novel variants, muscle imaging, and myopathological changes in Chinese patients with VCP‐related multisystem proteinopathy
by: Yalan Wan, et al.
Published: (2023-07-01)

Yeast proteinopathy models: a robust tool for deciphering the basis of neurodegeneration
by: Amit Shrestha, et al.
Published: (2015-11-01)

Quantitative patterns of motor cortex proteinopathy across ALS genotypes
by: Matthew Nolan, et al.
Published: (2020-07-01)

Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease
by: Ganguly G, et al.
Published: (2017-03-01)

Reduced oxidative stress suppresses neurotoxicity in the Drosophila model of TAF15-associated proteinopathies
by: Yeo Jeong Han, et al.
Published: (2022-11-01)

Polyphenols, Autophagy and Neurodegenerative Diseases: A Review
by: Vichitra Chandrasekaran, et al.
Published: (2023-07-01)

Proteinopathies as Hallmarks of Impaired Gene Expression, Proteostasis and Mitochondrial Function in Amyotrophic Lateral Sclerosis
by: Bridget C. Benson, et al.
Published: (2021-12-01)

Lycorine protects motor neurons against TDP-43 proteinopathy-induced degeneration in cross-species models with amyotrophic lateral sclerosis
by: Jing Wen, et al.
Published: (2024-12-01)

Propranolol reduces the accumulation of cytotoxic aggregates in C9orf72-ALS/FTD in vitro models
by: Mira Seidel, et al.
Published: (2023-01-01)