Terpenoids from
A new sesquiterpenoid, 1α,5α-epoxy-4α-hydroxyl-4β,10β-dimethyl-7αH,10αH-guaia-11(13)-en-12-oic acid ( 1 ), and four known compounds, lactucin ( 2 ), 1β-hydroxy-7αH,8,11βH-eudesm-3-en-8,12-olide ( 3 ), 13,14- seco -stigma 9(11),14(15)-dien-3α-ol ( 4 ), and bacosterol-3- O -β-D-glucopyranoside ( 5 ) w...
| Published in: | Natural Product Communications |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2012-08-01
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| Online Access: | https://doi.org/10.1177/1934578X1200700801 |
| Summary: | A new sesquiterpenoid, 1α,5α-epoxy-4α-hydroxyl-4β,10β-dimethyl-7αH,10αH-guaia-11(13)-en-12-oic acid ( 1 ), and four known compounds, lactucin ( 2 ), 1β-hydroxy-7αH,8,11βH-eudesm-3-en-8,12-olide ( 3 ), 13,14- seco -stigma 9(11),14(15)-dien-3α-ol ( 4 ), and bacosterol-3- O -β-D-glucopyranoside ( 5 ) were isolated from Cichorium intybus L. Their structures were determined on the basis of detailed analysis of their 1D- and 2D-NMR spectroscopic and mass spectrometric data. Compounds 2 and 4 showed strong activities against the A2780 cell line with IC 50 values of 1.81 and 0.07 μM, respectively. |
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| ISSN: | 1934-578X 1555-9475 |