Deciphering the importance of culture pH on CD22 CAR T-cells characteristics

Abstract Background Chimeric antigen receptor (CAR) T-cells have demonstrated significant efficacy in targeting hematological malignancies, and their use continues to expand. Despite substantial efforts spent on the optimization of protocols for CAR T-cell manufacturing, critical parameters of cell...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Michaela Prochazkova, Alexandra Dreyzin, Lipei Shao, Pam Garces, Yihua Cai, Rongye Shi, Alejandra Pelayo, Yong Soo Kim, Victoria Pham, Sue Ellen Frodigh, Shannon Fenton, Catherine Karangwa, Yan Su, Kathryn Martin, Nan Zhang, Steven L. Highfill, Robert P. Somerville, Nirali N. Shah, David F. Stroncek, Ping Jin
Format:	Article
Language:	English
Published:	BMC 2024-04-01
Subjects:	Chimeric antigen receptor (CAR) T-cells pH Clinical manufacturing Immunotherapy
Online Access:	https://doi.org/10.1186/s12967-024-05197-5