阿霉素负载的直链烷基修饰氧化石墨烯经导管动脉化疗栓塞治疗肝癌

【目的】研究阿霉素负载的直链烷基修饰的氧化石墨烯（DOX@GO-C18）作为药物载体经导管动脉化疗栓塞（TACE）治疗肝癌的安全性和有效性。【方法】制备并表征DOX@GO-C18。采用雄性新西兰大白兔建立VX2肝癌模型并以动态增强CT扫描明确肿瘤情况。在数字减影血管造影（DSA）引导下，以股动脉入路选择性插管至肝段动脉，通过微导管注射DOX@GO-C18的碘油分散液对肿瘤行TACE治疗。术前及术后第1、3、5、7和14天取外周静脉血液样本行肝功能检查，术后第14天行动态增强CT扫描并对肿瘤行HE染色、油红染色及DAPI荧光染色。【结果】DOX@GO-C18能稳定分散在碘油中。肝癌病灶在治疗前后...

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Bibliographic Details
Published in:	Zhongshan Daxue xuebao. Yixue kexue ban
Main Authors:	唐可禺, 林润, 姜云, 李楠, 陈斌, 张弢, 杨建勇, 黄勇慧
Format:	Article
Language:	Chinese
Published:	Editorial Office of Journal of Sun Yat-sen University 2019-01-01
Subjects:	直链烷基氧化石墨烯经导管动脉化疗栓塞肝癌
Online Access:	http://xuebaoyx.sysu.edu.cn/zh/article/43547564/

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