Neutrophils Isolated from Septic Patients Exhibit Elevated Uptake of Vitamin C and Normal Intracellular Concentrations despite a Low Vitamin C Milieu

Vitamin C (ascorbate) plays an important role in neutrophil function and is accumulated by the cells either directly via vitamin C transporters (SVCT) or indirectly following oxidation to dehydroascorbic acid. Septic patients are known to have significantly depleted plasma ascorbate status, but litt...

Full description

Bibliographic Details
Published in:	Antioxidants
Main Authors:	Anitra C. Carr, Stephanie Bozonet, Juliet Pullar, Emma Spencer, Patrice Rosengrave, Geoff Shaw
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Subjects:	ascorbate vitamin C dehydroascorbic acid sepsis septic shock neutrophils
Online Access:	https://www.mdpi.com/2076-3921/10/10/1607

Similar Items

Appropriate Handling, Processing and Analysis of Blood Samples Is Essential to Avoid Oxidation of Vitamin C to Dehydroascorbic Acid
by: Juliet M. Pullar, et al.
Published: (2018-02-01)

Influence of the Growing Conditions in the Content of Vitamin C in Diplotaxis erucoides
by: Carla GUIJARRO-REAL, et al.
Published: (2017-11-01)

The perils of planning strategies to increase vitamin C content in plants: Beyond the hype
by: Mattia Terzaghi, et al.
Published: (2022-12-01)

High Vitamin C Status Is Associated with Elevated Mood in Male Tertiary Students
by: Juliet M. Pullar, et al.
Published: (2018-07-01)

Mood improvement in young adult males following supplementation with gold kiwifruit, a high-vitamin C food
by: Anitra C. Carr, et al.
Published: (2013-01-01)

Intravenous vitamin C administration to patients with septic shock: a pilot randomised controlled trial
by: Patrice Rosengrave, et al.
Published: (2022-01-01)

Association between Vitamin C Deficiency and Mortality in Patients with Septic Shock
by: Jong Eun Park, et al.
Published: (2022-08-01)

Physiological and metabolomic analysis reveals maturity stage-dependent nitrogen regulation of vitamin C content in pepper fruit
by: Lu Zhang, et al.
Published: (2023-01-01)

New Insight on Phenolic Composition and Evaluation of the Vitamin C and Nutritional Value of Smoothies Sold on the Spanish Market
by: María del Carmen Razola-Díaz, et al.
Published: (2022-11-01)

SVCT2 Overexpression and Ascorbic Acid Uptake Increase Cortical Neuron Differentiation, Which Is Dependent on Vitamin C Recycling between Neurons and Astrocytes
by: Katterine Salazar, et al.
Published: (2021-09-01)

Application of a New Dehydroascorbic Acid Reducing Agent in the Analysis of Vitamin C Content in Food
by: Artur Mazurek, et al.
Published: (2021-10-01)

Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes
by: Anitra C. Carr, et al.
Published: (2017-12-01)

Reevaluating vitamin C in sepsis and septic shock: a potential benefit in severe cases?
by: Abdulrahman Alissa, et al.
Published: (2024-10-01)

Patterns of inflammatory immune responses in patients with septic shock receiving vitamin C, hydrocortisone, and thiamine: clustering analysis in Korea
by: Seung-Hun You, et al.
Published: (2023-08-01)

A New Method for the Determination of Total Content of Vitamin C, Ascorbic and Dehydroascorbic Acid, in Food Products with the Voltammetric Technique with the Use of Tris(2-carboxyethyl)phosphine as a Reducing Reagent
by: Artur Mazurek, et al.
Published: (2023-01-01)

Dehydroascorbic Acid Affects the Stability of Catechins by Forming Conjunctions
by: Lin Chen, et al.
Published: (2020-09-01)

Effect of Physiological Concentrations of Vitamin C on the Inhibitation of Hydroxyl Radical Induced Light Emission from Fe<sup>2+</sup>-EGTA-H<sub>2</sub>O<sub>2</sub> and Fe<sup>3+</sup>-EGTA-H<sub>2</sub>O<sub>2</sub> Systems In Vitro
by: Michal Nowak, et al.
Published: (2021-04-01)

Determination of Ascorbic Acid, Total Ascorbic Acid, and Dehydroascorbic Acid in Bee Pollen Using Hydrophilic Interaction Liquid Chromatography-Ultraviolet Detection
by: Meifei Zhu, et al.
Published: (2020-12-01)

Ascorbate metabolism in vegetative and reproductive organs of "cherry" tomato
by: G. Tsaniklidis, et al.
Published: (2014-09-01)

Vitamin C – a scoping review for Nordic Nutrition Recommendations 2023
by: Jens Lykkesfeldt, et al.
Published: (2023-12-01)

Over-Expression of Dehydroascorbate Reductase Improves Salt Tolerance, Environmental Adaptability and Productivity in <i>Oryza sativa</i>
by: Young-Saeng Kim, et al.
Published: (2022-05-01)

What are the conclusions of the recent studies about administrating vitamin C in sepsis? The review
by: Wiktor Wróblewski, et al.
Published: (2023-04-01)

Intravenous Vitamin C for Cancer Therapy – Identifying the Current Gaps in Our Knowledge
by: Anitra C. Carr, et al.
Published: (2018-08-01)

Reduced Plasma Ascorbate and Increased Proportion of Dehydroascorbic Acid Levels in Patients Undergoing Hemodialysis
by: Yuta Doshida, et al.
Published: (2021-09-01)

Nitric oxide donor SNP regulates the ascorbate and glutathione metabolism in Agropyron cristatum leaves through MEK1/2
by: C. Shan, et al.
Published: (2017-12-01)

Changes in the ascorbate-glutathione system during storage of recalcitrant seeds of Acer saccharinum L.
by: Ewelina Ratajczak, et al.
Published: (2011-01-01)

Effect of wounding intensity on physiological and quality changes of strawberry fruit
by: Mulugheta Solomon, et al.
Published: (2018-10-01)

Effect of ultraviolet and pulsed light treatments on ascorbic acid content in fruit juices-A review of the degradation mechanism
by: Somnath Basak, et al.
Published: (2023-10-01)

Low Vitamin C Concentrations in Patients with Community-Acquired Pneumonia Resolved with Pragmatic Administration of Intravenous and Oral Vitamin C
by: Anitra C. Carr, et al.
Published: (2023-08-01)

The Use of Intravenous Vitamin C as a Supportive Therapy for a Patient with Glioblastoma Multiforme
by: Nicola Baillie, et al.
Published: (2018-08-01)

The Efficacy of vitamin C, thiamine, and corticosteroid therapy in adult sepsis patients: a systematic review and meta-analysis
by: Manoj Kumar Reddy Somagutta, et al.
Published: (2021-08-01)

Oligogalacturonides stimulate antioxidant system in alfalfa roots
by: D. Camejo, et al.
Published: (2012-09-01)

Ascorbate-Glutathione Cycle Genes Families in Euphorbiaceae: Characterization and Evolutionary Analysis
by: Douglas Jardim-Messeder, et al.
Published: (2022-12-01)

Dehydroascorbic acid quantification in human plasma: Simultaneous direct measurement of the ascorbic acid/dehydroascorbic acid couple by UPLC/MS-MS
by: P.-C. Violet, et al.
Published: (2024-12-01)

Nitric oxide acts downstream of hydrogen peroxide in the regulation of ascorbate and glutathione metabolism by jasmonic acid in Agropyron cristatum leaves
by: C. Shan, et al.
Published: (2017-12-01)

High-dose vitamin-C induced prolonged factitious hyperglycemia in a peritoneal dialysis patient: a case report
by: Olivier Lachance, et al.
Published: (2021-05-01)

High-dose vitamin C and cancer
by: Ahmet Unlu, M.D., et al.
Published: (2016-01-01)

Estimating Vitamin C Intake Requirements in Diabetes Mellitus: Analysis of NHANES 2017–2018 and EPIC-Norfolk Cohorts
by: Anitra C. Carr, et al.
Published: (2023-10-01)

New role for thioredoxins in plants: Implication of TRXo1 in protein depersulfidation
by: Sabrina De Brasi-Velasco, et al.
Published: (2025-05-01)

Distribution and Functions of Monodehydroascorbate Reductases in Plants: Comprehensive Reverse Genetic Analysis of <i>Arabidopsis thaliana</i> Enzymes
by: Mio Tanaka, et al.
Published: (2021-10-01)