Analysis of the responses of rats ileum to the effect of aqueous rhizome extract of zingiber officinale

• Published in: International Journal of Medicine and Health Development
• Main Authors: F Agoreyo, M Omigie, P Itebiye
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2012-01-01
• Subjects: zingiber officinale; acetylcholine; atropine; muscarinic receptor
• Online Access: http://www.ijmhdev.com/article.asp?issn=2635-3695;year=2012;volume=17;issue=2;spage=24;epage=29;aulast=Agoreyo;type=0

Background: The gastrointestinal system is innervated by the sympathetic and parasympathetic components of the autonomic nervous system (ANS). ANS mediate its effect by the release of acetylcholine, a neurotransmitter secreted by the parasympathetic nervous system. Its stimulation produces increase intestinal motility, sphincter muscle relaxation and stimulation of secretion. The actions of acetylcholine can be blocked by using a cholinergic receptor, antagonist such as atropine. Aims: This study is aimed at determining the effect of aqueous rhizome extract of Zingiber officinale on an isolated rat ileum Result: The aqueous extract of Zingiber officinale produced similar effect as atropine, as seen when varied increasing doses(1mg/ml, 2mg/ml, 4mg/ml) of the extract was administered. It produced significant inhibition (P< 0.05) at 1mg/ml (P< 0.01) at 2mg/ml (P< 0.001) and at 4mg/ml intestinal motility respectively , indicating anti diarrhoea effect.