SHED-derived exosome-mimetics promotes rotator cuff tendon-bone healing via macrophage immunomodulation through NF-κB suppression and autophagy activation

Rotator cuff tendon-bone healing is impeded by inflammation and inadequate regeneration. This study evaluates exosome-mimetics (EMs) derived from stem cells of human exfoliated deciduous teeth (SHEDs) as a therapeutic strategy to enhance repair.SHED-EMs were synthesized via serial extrusion and char...

Full description

Bibliographic Details
Published in:	Materials Today Bio
Main Authors:	Yanwei He, Junzhe Sheng, Fashun Liu, Fangqi Li, Shihao Lu, Wenbo Chen, Li Yang, Peng Zhou, Zan Chen, Shiyi Chen, Zhiwen Luo, Junming Sun
Format:	Article
Language:	English
Published:	Elsevier 2025-10-01
Subjects:	Bioactive materials Exosome-mimetics Macrophages Immunomodulation Rotator cuff tear Tendon-to-bone healing
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590006425007161

Similar Items

Exosomes derived from tendon stem/progenitor cells enhance tendon-bone interface healing after rotator cuff repair in a rat model
by: Yanwei He, et al.
Published: (2024-10-01)

Magnetic resonance imaging could precisely define the mean value of tendon thickness in partial rotator cuff tears
by: Umile Giuseppe Longo, et al.
Published: (2023-09-01)

Rotator cuff irreparability or failure of repair (re‐tear): technical note on middle trapezius tendon transfer for reproduction of supraspinatus function
by: Amr Abdel‐Mordy Kandeel
Published: (2021-01-01)

Comparison of clinical outcomes of anterior combined latissimus dorsi and teres major tendon transfer for anterior superior irreparable rotator cuff tear between young and elderly patients
by: Chang Hee Baek, et al.
Published: (2024-08-01)

Histologic and ultrastructural degeneration of rotator cuff tendons in elderly patients with glenohumeral arthritis and cuff tear arthropathy
by: Daisuke Mori, et al.
Published: (2025-07-01)

Tendon stump change as a risk factor for structural failure of arthroscopic rotator cuff repair
by: Jun Kawamata, MD, et al.
Published: (2025-07-01)

Arthroscopic cuff repair: footprint remnant preserving versus debriding rotator cuff repair of transtendinous rotator cuff tears with remnant cuff
by: Jae Min Lee, et al.
Published: (2024-04-01)

Biceps-based 3-layer reconstruction of the irreparable rotator cuff: a technical note on biceps tendon as a common local graft for in-situ superior capsular reconstruction, partial cuff repair, and middle trapezius tendon transfer
by: Amr Abdel-Mordy Kandeel
Published: (2023-07-01)

The interplay between mesenchymal stem cells and the immune microenvironment in rotator cuff tendon-to-bone healing: current progress and future directions
by: Dong Li, et al.
Published: (2025-09-01)

Identification of age-related genes in rotator cuff tendon: a preliminary transcriptome study on tendon ageing
by: Yibin Liu, et al.
Published: (2024-09-01)

Bioactive Patch for Rotator Cuff Repairing via Enhancing Tendon‐to‐Bone Healing: A Large Animal Study and Short‐Term Outcome of a Clinical Trial
by: Yuhao Kang, et al.
Published: (2024-08-01)

Sirtuin 6 Overexpression Improves Rotator Cuff Tendon-to-Bone Healing in the Aged
by: Young Jae Moon, et al.
Published: (2023-08-01)

Superior capsule reconstruction, partial cuff repair, graft interposition, arthroscopic debridement or balloon spacers for large and massive irreparable rotator cuff tears: a systematic review and meta-analysis
by: Andrew Davies, et al.
Published: (2022-12-01)

A technique for arthroscopic-assisted lower trapezius transfer using an Achilles tendon allograft augmented with acellular dermal matrix to treat posterior superior irreparable rotator cuff tears in the lateral decubitus position
by: Chang Hee Baek, et al.
Published: (2025-04-01)

Reconstruction of large chronic rotator cuff tear can benefit from the bone–tendon composite autograft to restore the native bone–tendon interface
by: Yucheng Sun, et al.
Published: (2020-09-01)

Rotator cuff repair with all-suture anchor enhances biomechanical properties and tendon-bone integration in a rabbit model
by: Chengxuan Yu, et al.
Published: (2024-09-01)

Diagnostic accuracy of magnetic resonance imaging for partial tears of the long head of the biceps tendon in patients with rotator cuff tears
by: Yuji Shibayama, MD, PhD, et al.
Published: (2022-07-01)

Latissimus dorsi tendon transfers for irreparable rotator cuff tears after inferior glenohumeral dislocation: a rare case report
by: Necip Guven, MD, et al.
Published: (2025-11-01)

Tissue‐engineered tendon nano‐constructs for repair of chronic rotator cuff tears in large animal models
by: Yonghyun Gwon, et al.
Published: (2023-01-01)

Arthroscopic-assisted Latissimus Dorsi Tendon Transfer for the Management of Irreparable Rotator Cuff Tears in Middle-aged Physically Active Patients
by: Tae Kang Lim, et al.
Published: (2019-03-01)

Exploring superior capsular reconstruction and tendon transfers for massive irreparable posterosuperior rotator cuff tears
by: Majd Mzeihem, et al.
Published: (2025-09-01)

Decellularized tendon patch enhance biological and mechanical healing of large-to-massive rotator cuff tear in a rat chronic model: a comparison study of patch sterilization and storage methods
by: Yiyang Mao, et al.
Published: (2025-03-01)

Clinical outcome of revision lower trapezius tendon transfer after failed lower trapezius tendon transfer: a case report
by: Chang Hee Baek, MD, et al.
Published: (2025-02-01)

Early Efficacy Assessment of Arthroscopic Lower Trapezius Transfer With Tendon Autograft in the Management of Massive Irreparable Posterosuperior Rotator Cuff Tears
by: Lingchao Ye, et al.
Published: (2022-01-01)

Second-look arthroscopic evaluation of transferred graft integrity during capsular release on patient with adhesive capsulitis after lower trapezius tendon transfer: a case report
by: Chang Hee Baek, MD, et al.
Published: (2024-05-01)

Fixation of the rotator cuff tendons for the greater tuberosity fracture of the humerus
by: Alexey A. Makovskiy, et al.
Published: (2024-08-01)

Initiation and progression of rotator cuff tears due to fatigue loading: a cadaveric study
by: Mason J. Garcia, BS, et al.
Published: (2025-07-01)

Enhanced rotator cuff tendon-bone interface regeneration with injectable manganese-based mesoporous silica nanoparticle-loaded dual crosslinked hydrogels
by: Zihang Chen, et al.
Published: (2025-08-01)

Crimped nanofiber scaffold mimicking tendon-to-bone interface for fatty-infiltrated massive rotator cuff repair
by: Liren Wang, et al.
Published: (2022-10-01)

Arthroscopic repair of large and massive rotator cuff tears—“sandwich augmentation” with the long head of the biceps tendon: a technical note
by: Sung Joon Yoon, et al.
Published: (2024-03-01)

Mid-term Clinical and Radiological Outcomes of Latissimus Dorsi Tendon Transfer in Massive Rotator Cuff Tears
by: Dongwhan Suh, et al.
Published: (2019-12-01)

Middle trapezius transfer for treatment of irreparable supraspinatus tendon tears‐ anatomical feasibility study
by: Philipp Moroder, et al.
Published: (2021-01-01)

An objective assessment of the impact of tendon retraction on sleep efficiency in patients with full-thickness rotator cuff tears: a prospective cohort study
by: Ashley E. MacConnell, et al.
Published: (2023-06-01)

Achilles tendon allograft versus fascia lata autograft as the interpositional graft in arthroscopically assisted lower trapezius tendon transfer for irreparable posterosuperior rotator cuff tear
by: Chang Hee Baek, et al.
Published: (2025-05-01)

Characterization of tendon cell cultures of the human rotator cuff
by: S Pauly
Published: (2010-07-01)

Imaging and histological evaluation of the long head of the biceps tendon in the presence of different types of rotator cuff tears
by: Daisuke Kajiwara, et al.
Published: (2023-03-01)

Protocatechuic acid impacts rotator cuff healing and reduces fatty degeneration in a chronic rotator cuff tear model in rats
by: Su-Jung Seo, et al.
Published: (2022-03-01)

Caveolin-1 is involved in fatty infiltration and bone-tendon healing of rotator cuff tear
by: Shanhong Fang, et al.
Published: (2023-03-01)

Comparative outcomes of supraspinatus tendon reconstruction and superior capsule reconstruction for massive irreparable posterosuperior rotator cuff tears
by: Zhenyu Wang, et al.
Published: (2025-08-01)

Factors associated with pain in nonsurgically treated rotator cuff tears -A study with magnetic resonance imaging
by: Yoshihiro Nakamura, et al.
Published: (2019-05-01)