| Summary: | Due to its application as an anti-cancer drug, pazopanib (<b>1</b>) has attracted the interest of many researchers, and several studies on pazopanib synthesis have been reported over the years. This paper provides a novel route for synthesizing <i>N</i>,2,3-trimethyl-2<i>H</i>-indazol-6-amine (<b>5</b>), which is a crucial building block in the synthesis of pazopanib from 3-methyl-6-nitro-1<i>H</i>-indazole (<b>6</b>). By alternating between the reduction and two methylation steps, compound <b>5</b> was obtained in a yield comparable (55%) to what has been reported (54%). It is noteworthy that the last step of N<sup>2</sup>-methylation also yielded <i>N</i>,<i>N</i>,2,3-tetramethyl-2<i>H</i>-indazol-6-amine (<b>5′</b>) as a novel compound. Furthermore, the data presented in this paper can serve as a valuable resource for future research aimed at further refining the process of synthesizing pazopanib and its derivatives.
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