Recent advances on CAR-T signaling pave the way for prolonged persistence and new modalities in clinic

Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of hematological malignancies. The importance of the receptor costimulatory domain for long-term CAR-T cell engraftment and therapeutic efficacy was demonstrated with second-generation CAR-T cells. Fifth generation CAR...

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Bibliographic Details
Published in:Frontiers in Immunology
Main Authors: Sergei Smirnov, Polina Mateikovich, Konstantin Samochernykh, Evgeny Shlyakhto
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Subjects:
CAR (chimeric antigen receptor)
persistence
activation
costimulatory
signaling
T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1335424/full
Description
Summary:Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of hematological malignancies. The importance of the receptor costimulatory domain for long-term CAR-T cell engraftment and therapeutic efficacy was demonstrated with second-generation CAR-T cells. Fifth generation CAR-T cells are currently in preclinical trials. At the same time, the processes that orchestrate the activation and differentiation of CAR-T cells into a specific phenotype that predisposes them to long-term persistence are not fully understood. This review highlights ongoing research aimed at elucidating the role of CAR domains and T-cell signaling molecules involved in these processes.
ISSN:1664-3224

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