Combining Therapeutic Drug Monitoring and Pharmacokinetic Modelling Deconvolutes Physiological and Environmental Sources of Variability in Clozapine Exposure

<b>Background:</b> Clozapine is a key antipsychotic drug for treatment-resistant schizophrenia but exhibits highly variable pharmacokinetics and a propensity for serious adverse effects. Currently, these challenges are addressed using therapeutic drug monitoring (TDM). This study primari...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Kenneth H. Wills, Stephen J. Behan, Michael J. Nance, Jessica L. Dawson, Thomas M. Polasek, Ashley M. Hopkins, Madelé van Dyk, Andrew Rowland
Format:	Article
Language:	English
Published:	MDPI AG 2021-12-01
Subjects:	therapeutic drug monitoring clozapine pharmacokinetic modelling inter-individual variability dose optimisation medication adherence
Online Access:	https://www.mdpi.com/1999-4923/14/1/47