Transcriptomic profiling of cumulus cells reveals dysregulated genes and pathways in PCOS-related infertility

Abstract Background Polycystic ovarian syndrome (PCOS) is a leading cause of infertility and metabolic dysfunction in women, characterized by hyperandrogenism, anovulation, and insulin resistance. Cumulus cells play a crucial role in folliculogenesis and oocyte maturation, necessitating a deeper und...

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Bibliographic Details
Published in:	Middle East Fertility Society Journal
Main Authors:	Akeem Babatunde Sikiru, Nurulfiza Mat Isa, Kasim Sakran Abass, Muibat Adesola Adeniran, Stephen Sunday Acheneje Egena, Karimot Akinola
Format:	Article
Language:	English
Published:	SpringerOpen 2025-08-01
Subjects:	PCOS Cumulus cells GNAT1 Oocyte competence, Infertility
Online Access:	https://doi.org/10.1186/s43043-025-00241-w

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