New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets

Several anti-inflammatory agents based on pyrazole and imidazopyrazole scaffolds and a large library of substituted catechol PDE4D inhibitors were reported by us in the recent past. To obtain new molecules potentially able to act on different targets involved in inflammation onset we designed and sy...

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Bibliographic Details
Published in:	Molecules
Main Authors:	Chiara Brullo, Matteo Massa, Federica Rapetti, Silvana Alfei, Maria B. Bertolotto, Fabrizio Montecucco, Maria Grazia Signorello, Olga Bruno
Format:	Article
Language:	English
Published:	MDPI AG 2020-02-01
Subjects:	pyrazole-4-carbohydrazides imidazopyrazole-7-carbohydrazides reactive oxygen production inhibition platelets neutrophils phosphodiesterase inhibitors
Online Access:	https://www.mdpi.com/1420-3049/25/4/899

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