Metallacarborane Synthons for Molecular Construction—Oligofunctionalization of Cobalt Bis(1,2-dicarbollide) on Boron and Carbon Atoms with Extendable Ligands
The exploitation of metallacarboranes’ potential in various fields of research and practical applications requires the availability of convenient and versatile methods for their functionalization with various functional moieties and/or linkers of different types and lengths. Herein, we report a stud...
| Published in: | Molecules |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Online Access: | https://www.mdpi.com/1420-3049/28/10/4118 |
| _version_ | 1850404208286629888 |
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| author | Krzysztof Śmiałkowski Carla Sardo Zbigniew J. Leśnikowski |
| author_facet | Krzysztof Śmiałkowski Carla Sardo Zbigniew J. Leśnikowski |
| author_sort | Krzysztof Śmiałkowski |
| collection | DOAJ |
| container_title | Molecules |
| description | The exploitation of metallacarboranes’ potential in various fields of research and practical applications requires the availability of convenient and versatile methods for their functionalization with various functional moieties and/or linkers of different types and lengths. Herein, we report a study on cobalt bis(1,2-dicarbollide) functionalization at 8,8′-boron atoms with different hetero-bifunctional moieties possessing a protected hydroxyl function allowing further modification after deprotection. Moreover, an approach to the synthesis of three and four functionalized metallacarboranes, at boron and carbon atoms simultaneously via additional functionalization at carbon to obtain derivatives carrying three or four rationally oriented and distinct reactive surfaces, is described. |
| format | Article |
| id | doaj-art-e7d27fbc3ce04548be6d91cd1cfa74a8 |
| institution | Directory of Open Access Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-e7d27fbc3ce04548be6d91cd1cfa74a82025-08-19T22:48:58ZengMDPI AGMolecules1420-30492023-05-012810411810.3390/molecules28104118Metallacarborane Synthons for Molecular Construction—Oligofunctionalization of Cobalt Bis(1,2-dicarbollide) on Boron and Carbon Atoms with Extendable LigandsKrzysztof Śmiałkowski0Carla Sardo1Zbigniew J. Leśnikowski2Laboratory of Medicinal Chemistry, Institute of Medical Biology Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, PolandLaboratory of Medicinal Chemistry, Institute of Medical Biology Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, PolandLaboratory of Medicinal Chemistry, Institute of Medical Biology Polish Academy of Sciences, Lodowa 106, 93-232 Lodz, PolandThe exploitation of metallacarboranes’ potential in various fields of research and practical applications requires the availability of convenient and versatile methods for their functionalization with various functional moieties and/or linkers of different types and lengths. Herein, we report a study on cobalt bis(1,2-dicarbollide) functionalization at 8,8′-boron atoms with different hetero-bifunctional moieties possessing a protected hydroxyl function allowing further modification after deprotection. Moreover, an approach to the synthesis of three and four functionalized metallacarboranes, at boron and carbon atoms simultaneously via additional functionalization at carbon to obtain derivatives carrying three or four rationally oriented and distinct reactive surfaces, is described.https://www.mdpi.com/1420-3049/28/10/4118metallacarboranescobalt bis(1,2-dicarbollide)oligofunctionalizationalkylationstereochemistry |
| spellingShingle | Krzysztof Śmiałkowski Carla Sardo Zbigniew J. Leśnikowski Metallacarborane Synthons for Molecular Construction—Oligofunctionalization of Cobalt Bis(1,2-dicarbollide) on Boron and Carbon Atoms with Extendable Ligands metallacarboranes cobalt bis(1,2-dicarbollide) oligofunctionalization alkylation stereochemistry |
| title | Metallacarborane Synthons for Molecular Construction—Oligofunctionalization of Cobalt Bis(1,2-dicarbollide) on Boron and Carbon Atoms with Extendable Ligands |
| title_full | Metallacarborane Synthons for Molecular Construction—Oligofunctionalization of Cobalt Bis(1,2-dicarbollide) on Boron and Carbon Atoms with Extendable Ligands |
| title_fullStr | Metallacarborane Synthons for Molecular Construction—Oligofunctionalization of Cobalt Bis(1,2-dicarbollide) on Boron and Carbon Atoms with Extendable Ligands |
| title_full_unstemmed | Metallacarborane Synthons for Molecular Construction—Oligofunctionalization of Cobalt Bis(1,2-dicarbollide) on Boron and Carbon Atoms with Extendable Ligands |
| title_short | Metallacarborane Synthons for Molecular Construction—Oligofunctionalization of Cobalt Bis(1,2-dicarbollide) on Boron and Carbon Atoms with Extendable Ligands |
| title_sort | metallacarborane synthons for molecular construction oligofunctionalization of cobalt bis 1 2 dicarbollide on boron and carbon atoms with extendable ligands |
| topic | metallacarboranes cobalt bis(1,2-dicarbollide) oligofunctionalization alkylation stereochemistry |
| url | https://www.mdpi.com/1420-3049/28/10/4118 |
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