Network pharmacology and metabolomics analysis of Tinospora cordifolia reveals BACE1 and MAOB as potential therapeutic targets for neuroprotection in Alzheimer’s disease

Abstract Tinospora cordifolia has been used for thousands of years to treat various health conditions, including neurodegenerative diseases. The study aimed to elucidate the mechanism of action and protein targets of T. cordifolia in the context of Alzheimer’s disease through untargeted metabolomics...

Full description

Bibliographic Details
Published in:	Scientific Reports
Main Authors:	S. Amrutha, Chandran S. Abhinand, Shubham Sukerndeo Upadhyay, Ravishankar Parvaje, Thottethodi Subrahmanya Keshava Prasad, Prashant Kumar Modi
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-03-01
Subjects:	Tinospora cordifolia Medhya rasayana Untargeted metabolomics Neuroprotection Therapeutic targets
Online Access:	https://doi.org/10.1038/s41598-025-92756-5

Similar Items

Effect of combination of Phyllanthus emblica, Tinospora cordifolia, and Ocimum sanctum on spatial learning and memory in rats
by: Harshad O Malve, et al.
Published: (2014-01-01)

Guduchi (tinospora cordifolia [wild.] miers) and its therapeutic external applications: A comprehensive review
by: Anu Joy, et al.
Published: (2021-01-01)

Current biological and pharmacological updates on Tinospora cordifolia
by: Shubham Kumar, et al.
Published: (2024-05-01)

Indian herb Tinospora cordifolia and Tinospora species: Phytochemical and therapeutic application
by: Anu Chaudhary, et al.
Published: (2024-05-01)

Giloy (Tinospora Cordifolia): A COVID-19 herbal drug causing erythroderma in a pediatric patient
by: Apoorva Gupta, et al.
Published: (2023-01-01)

Comparative antidiarrheal and antiulcer effect of the aqueous and ethanolic stem bark extracts of Tinospora cordifolia in rats
by: Mohanjit Kaur, et al.
Published: (2014-01-01)

Antioxidant activity of ethanolic extract of Tinospora cordifolia on N-nitrosodiethylamine (diethylnitrosamine) induced liver cancer in male Wister albino rats
by: R Jayaprakash, et al.
Published: (2015-01-01)

Genetic variability, heritability, correlation and path analysis in seenthil kodi (Tinospora cordifolia)
by: BC. Akhilraj1, J. Suresh2*, K. Rajamani3, M. Kumar4 and R. Gnanam5
Published: (2023-06-01)

Phytochemical and Antimicrobial Activity of Fumes and Powder Extracts of Tinospora cordifolia
by: Ekta Chandel, et al.
Published: (2022-10-01)

Seasonal variations in physicochemical profiles of Guduchi Satva (starchy substance from Tinospora cordifolia [Willd.] Miers)
by: Rohit Sharma, et al.
Published: (2013-01-01)

A Clinical Evaluation of Guduchi (Tinospora cordifolia) and Yashtimadhu (Glycyrrhiza glabra) as Chemopreventive Agent in Cancer Treatment
by: Vijay Kumar Beriwal, et al.
Published: (2019-07-01)

Modulatory effect of Tinospora cordifolia extract on Cd-induced oxidative stress in Wistar rats
by: Viswanadha Vijaya Padma, et al.
Published: (2016-03-01)

ANTIPSYCHOTIC ACTIVITY OF AQUEOUS ETHANOLIC EXTRACT OF TINOSPORA CORDIFOLIA IN AMPHETAMINE CHALLENGED MICE MODEL
by: Abhilasha Shete, et al.
Published: (2010-03-01)

Mycobial contamination and mycotoxinogenesis of Tinospora cordifolia: an important medicinal plant of India
by: S. Sharma
Published: (2013-12-01)

A Detail Review on Heart-Leaved Moonseed (Tinospora cordifolia) Medicinal Plant
by: Vinotha Sanmugarajah, et al.
Published: (2022-11-01)

Qualitative and Quantitative Phytochemical Screening of Tinospora cordifolia (Willd.)
by: R. Nagalakshmi, et al.
Published: (2023-08-01)

In vitro cytotoxicity of Tinospora cordifolia stem extract in Daltons Lymphoma Ascites cell lines
by: O. Shyju, et al.
Published: (2023-09-01)

Effectiveness of Tinospora cordifolia in comparison to tramadol for analgesic activity in albino rats
by: Syed Gulam Ahmed, et al.
Published: (2023-09-01)

Tinospora cordifolia as a potential neuroregenerative candidate against glutamate induced excitotoxicity: an in vitro perspective
by: Anuradha Sharma, et al.
Published: (2018-10-01)

Antidiabetic claims of Tinospora cordifolia (Willd.) Miers: critical appraisal and role in therapy
by: Rohit Sharma, et al.
Published: (2015-01-01)

Comparative study of amrutbhallataka and glucosamine sulphate in osteoarthritis: Six months open label randomized controlled clinical trial
by: Ashwinikumar Raut, et al.
Published: (2013-01-01)

A pilot clinical study of an add-on Ayurvedic formulation containing Tinospora cordifolia and Piper longum in mild to moderate COVID-19
by: Sushila Kataria, et al.
Published: (2022-04-01)

Insight into Metabolomic Profiling of Tinospora cordifolia: Recent Advances and Future Perspectives of Quality Control
by: Atiqul Islam, et al.
Published: (2024-05-01)

Unveiling Various Facades of <i>Tinospora cordifolia</i> Stem in Food: Medicinal and Nutraceutical Aspects
by: Varisha Anjum, et al.
Published: (2023-10-01)

Influence of bypass fatty acid and Tinospora cordifolia supplementation on uterine involution, follicular development, and reproductive performance of Murrah buffaloes
by: RAJNEESH RAJNEESH, et al.
Published: (2022-04-01)

Vanadium oxide nanorods as DNA cleaving and anti-angiogenic agent: novel green synthetic approach using leaf extract of Tinospora cordifolia
by: P. Deepika, et al.
Published: (2020-02-01)

Mini cutting technique: an easy and cost-effective way of Tinospora cordifolia multiplication
by: PARMESHWAR LAL SARAN, et al.
Published: (2019-02-01)

Physical, Morphological, Tensile, and Thermal Stability Characteristics of Novel Tinospora Cordifolia Natural Fiber
by: Jamaluddin Hindi, et al.
Published: (2025-12-01)

Efficacy of dietary supplementation of Tinospora cordifolia stem in prevention of sub-acute lactic acidosis in goats
by: AKHILESH KUMAR, et al.
Published: (2019-08-01)

Extraction and Characterization of Antimicrobial surgical Suture from the bast of Tinospora Cordifolia
by: Shohag Chandra Das, et al.
Published: (2022-11-01)

Treatment with Tinospora cordifolia ameliorates prenatal stress and maternal separation-induced memory deficits by restoring amygdaloid neuronal architecture
by: Ashwini LS, et al.
Published: (2024-10-01)

Dietary Supplementation With Tinospora cordifolia Improves Anxiety-Type Behavior and Cognitive Impairments in Middle-Aged Acyclic Female Rats
by: Anmol Bhandari, et al.
Published: (2022-07-01)

Microencapsulation of Azadirachta indica oil and Tinospora cordifolia extracts blend for single-use applications
by: Olin Khan, et al.
Published: (2024-10-01)

Tinospora cordifolia (Giloy): An insight on the multifarious pharmacological paradigms of a most promising medicinal ayurvedic herb
by: Abhishek Gupta, et al.
Published: (2024-02-01)

Acute sleep deprivation-induced hepatotoxicity and dyslipidemia in middle-aged female rats and its amelioration by butanol extract of Tinospora cordifolia
by: Payal Bajaj, et al.
Published: (2024-08-01)

Humoral immune and adjuvant responses of mucosally-administered Tinospora cordifolia immunomodulatory protein in BALB/c mice
by: Ivan Aranha, et al.
Published: (2020-04-01)

Preclusion of radiation-mediated hematological and biochemical variations by root extract of Tinospora cordifolia (an indian medicinal plant)
by: Sharma Priyanka, et al.
Published: (2013-01-01)

Enhancing the corrosion inhibition performance of Tinospora cordifolia extract using different fractions of methanol solvent on carbon steel corrosion in a seawater-simulated solution
by: Ahmad Royani, et al.
Published: (2023-12-01)

Eco-friendly biosynthesis and characterization of silver nanoparticles using Tinospora cordifolia (Thunb.) Miers and evaluate its antibacterial, antioxidant potential
by: Kandasamy Selvam, et al.
Published: (2017-01-01)

Investigation of a novel biocide material for biocorrosion in simulated seawater: A case study on Tinospora cordifolia extract
by: Ahmad Royani, et al.
Published: (2024-12-01)