miR-152 Attenuates Apoptosis in Chondrocytes and Degeneration of Cartilages in Osteoarthritis Rats via TCF-4 Pathway

Introduction: Osteoarthritis (OA) is associated with deregulation of various miRNAs (miRs). The present study reported protective effect of miR-152 in osteoarthritis. Methods: Tissue cartilage tissues of OA and normal subjects were used, rat model of anterior cruciate ligament transection (ACLT) was...

Full description

Bibliographic Details
Published in:	Dose-Response
Main Authors:	Daqian Wan, Yang Qu, Songtao Ai, Liming Cheng
Format:	Article
Language:	English
Published:	SAGE Publishing 2020-10-01
Online Access:	https://doi.org/10.1177/1559325820946918

Similar Items

XMU-MP-1 attenuates osteoarthritis via inhibiting cartilage degradation and chondrocyte apoptosis
by: Xue Hao, et al.
Published: (2022-09-01)

Fibronectin Peptide FNIII14 Enhances Progressive Cartilage Degeneration in Osteoarthritis by Inducing Chondrocyte Apoptosis
by: Fumihiro Nishimura, et al.
Published: (2026-06-01)

HDAC4 represses ER stress induced chondrocyte apoptosis by inhibiting ATF4 and attenuates cartilage degeneration in an osteoarthritis rat model
by: Xiaodong Gu, et al.
Published: (2024-06-01)

Isorhynchophylline alleviates cartilage degeneration in osteoarthritis by activating autophagy of chondrocytes
by: Jieyun Jiang, et al.
Published: (2023-03-01)

Regulation of apoptosis and interaction with cartilage degeneration in osteoarthritis
by: Jiahua Mei, et al.
Published: (2025-03-01)

LncRNA CASC19 accelerates chondrocytes apoptosis and proinflammatory cytokine production to exacerbate osteoarthritis development through regulating the miR-152-3p/DDX6 axis
by: Chang Zhou, et al.
Published: (2021-06-01)

Effect of Electroacupuncture on Chondrocyte Apoptosis and Cartilage Matrix of Experimental Rats with Knee Osteoarthritis
by: Guangwen WU, et al.
Published: (2017-10-01)

Role of Chondrocytes in Cartilage Formation, Progression of Osteoarthritis and Cartilage Regeneration
by: Hemanth Akkiraju, et al.
Published: (2015-12-01)

Monotropein attenuates apoptosis and pyroptosis in chondrocytes and alleviates osteoarthritis progression in mice
by: Zhen Li, et al.
Published: (2023-04-01)

MiR-4303 relieves chondrocyte inflammation by targeting ASPN in osteoarthritis
by: Chunyu Wang, et al.
Published: (2021-10-01)

miR-124-3p sabotages lncRNA MALAT1 stability to repress chondrocyte pyroptosis and relieve cartilage injury in osteoarthritis
by: Rigbat Rozi, et al.
Published: (2022-10-01)

Potential of miR-25-3p in protection of chondrocytes: emphasis on osteoarthritis
by: Xiao He, et al.
Published: (2021-03-01)

Pathological perspective of chondrocyte apoptosis in osteoarthritis
by: Abhijeet Kunwar, et al.
Published: (2017-01-01)

miR-142-5p as a CXCR4-Targeted MicroRNA Attenuates SDF-1-Induced Chondrocyte Apoptosis and Cartilage Degradation via Inactivating MAPK Signaling Pathway
by: Yaoyv Xiang, et al.
Published: (2020-01-01)

Targeting FAP-positive chondrocytes in osteoarthritis: a novel lipid nanoparticle siRNA approach to mitigate cartilage degeneration
by: Xiang Zhao, et al.
Published: (2024-10-01)

Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis
by: Changyuan Huang, et al.
Published: (2025-03-01)

MiR-653-5p drives osteoarthritis pathogenesis by modulating chondrocyte senescence
by: Yucheng Lin, et al.
Published: (2024-05-01)

miR-520c-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GAS2
by: Le Peng, et al.
Published: (2021-05-01)

Unveiling MiR-3085-3p as a modulator of cartilage degeneration in facet joint osteoarthritis: A novel therapeutic target
by: Zhong-ming Lai, et al.
Published: (2025-01-01)

Long non-coding RNA LINC00265 promotes proliferation, apoptosis, and inflammation of chondrocytes in osteoarthritis by sponging miR-101-3p
by: Hanlin Zou, et al.
Published: (2021-11-01)

Electro-acupuncture modulated miR-214 expression to prevent chondrocyte apoptosis and reduce pain by targeting BAX and TRPV4 in osteoarthritis rats
by: Jia He, et al.
Published: (2024-05-01)

Protective effects of ectoine on articular chondrocytes and cartilage in rats for treating osteoarthritis.
by: Peng Li, et al.
Published: (2024-01-01)

The combined intervention of antibiotics and sodium butyrate attenuated the degeneration of osteoarthritis cartilage: An experimental rat model
by: Chengcheng Zhao, et al.
Published: (2023-11-01)

Collagen II hydrogel-mediated sustained delivery of lacosamide attenuates cartilage degeneration and pain in osteoarthritis
by: Chaopeng He, et al.
Published: (2026-07-01)

miR-1 Inhibits the Ferroptosis of Chondrocyte by Targeting CX43 and Alleviates Osteoarthritis Progression
by: Ming Zhou, et al.
Published: (2023-01-01)

Chelidonine reduces IL-1β-induced inflammation and matrix catabolism in chondrocytes and attenuates cartilage degeneration and synovial inflammation in rats
by: Mao Li, et al.
Published: (2023-08-01)

Iron triggers the early stages of cartilage degeneration in vitro: The role of articular chondrocytes
by: A.V. Ferreira, et al.
Published: (2021-06-01)

The Level of Histone Deacetylase 4 is Associated with Aging Cartilage Degeneration and Chondrocyte Hypertrophy
by: Dong Z, et al.
Published: (2022-06-01)

Circ_0116061 regulated the proliferation, apoptosis, and inflammation of osteoarthritis chondrocytes through regulating the miR-200b-3p/SMURF2 axis
by: Wei Zheng, et al.
Published: (2021-04-01)

CircSCAPER knockdown attenuates IL-1β-induced chondrocyte injury by miR-127-5p/TLR4 axis in osteoarthritis
by: Yuchang Zhang, et al.
Published: (2022-11-01)

MiR-760 targets HBEGF to control cartilage extracellular matrix degradation in osteoarthritis
by: Yingchun Zhu, et al.
Published: (2023-03-01)

FUNCTIONS OF THE mTOR SIGNALING PATHWAY IN NORMAL ARTICULAR CARTILAGE CHONDROCYTES AND IN OSTEOARTHRITIS
by: E. V. Chetina, et al.
Published: (2016-12-01)

Unveiling the role of hypertrophic chondrocytes in abnormal cartilage calcification: insights into osteoarthritis mechanisms
by: JP Yao, et al.
Published: (2024-06-01)

miR-26a-5p is a Stable Reference Gene for miRNA Studies in Chondrocytes from Developing Human Cartilage
by: Enrico Ragni, et al.
Published: (2019-06-01)

Increased apoptosis in human knee osteoarthritis cartilage related to the expression of protein kinase B and protein kinase C&#945; in chondrocytes
by: Chun Xia, et al.
Published: (2012-04-01)

MiR-148b, MiR-152/ALCAM Axis Regulates the Proliferation and Invasion of Pituitary Adenomas Cells
by: Wei He, et al.
Published: (2017-11-01)

The role of miR-152 in urological tumors: potential biomarkers and therapeutic targets
by: Xin Li, et al.
Published: (2024-11-01)

miR-152 Regulates Bovine Myoblast Proliferation by Targeting KLF6
by: Chengchuang Song, et al.
Published: (2021-10-01)

BMSC-Derived Exosomes Ameliorate Osteoarthritis by Inhibiting Pyroptosis of Cartilage via Delivering miR-326 Targeting HDAC3 and STAT1//NF-κB p65 to Chondrocytes
by: Honggang Xu, et al.
Published: (2021-01-01)

Role of Syndecan-4 in the Inhibition of Articular Cartilage Degeneration in Osteoarthritis
by: Yoshio Hattori, et al.
Published: (2023-08-01)