Low-Dose Alfentanil Effectively Reduces the ED50 of Remimazolam for Loss of Consciousness in Pediatric Patients Undergoing General Anesthesia: A Study Using Up-and-Down Sequential Allocation Method
Xinyuan Shi,1,* Fuxia Yi,2,3,* Hongyi Xiao,2,3 Shiyu Yu,1 Xiaohan Sun,1 Yaxin Wei,1 Fangli Yue,2,3 Fanceng Ji2,3 1School of Anaesthesiology,Shandong Second Medical University, Weifang, People’s Republic of China; 2Department of Anaesthesiology,Weifang People’s Hospital, Weifa...
| Published in: | Drug Design, Development and Therapy |
|---|---|
| Main Authors: | Shi X, Yi F, Xiao H, Yu S, Sun X, Wei Y, Yue F, Ji F |
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-08-01
|
| Subjects: | |
| Online Access: | https://www.dovepress.com/low-dose-alfentanil-effectively-reduces-the-ed50-of-remimazolam-for-lo-peer-reviewed-fulltext-article-DDDT |
Similar Items
Alfentanil Enhanced the Sedation of Remimazolam During Anaesthesia Induction in Patients Undergoing Urological Day Surgery: A Randomised Controlled Trial
by: Lin Y, et al.
Published: (2025-07-01)
by: Lin Y, et al.
Published: (2025-07-01)
Moderate sedation by total intravenous remimazolam-alfentanil vs. propofol-alfentanil for third molar extraction: A prospective randomized controlled trial
by: Nan Zhao, et al.
Published: (2022-09-01)
by: Nan Zhao, et al.
Published: (2022-09-01)
Determination of ED50 and ED95 of remimazolam besylate combined with alfentanil for adult gastroscopy: a prospective dose-finding study
by: Pingjuan Wang, et al.
Published: (2024-07-01)
by: Pingjuan Wang, et al.
Published: (2024-07-01)
Remimazolam-remifentanil causes less postoperative nausea and vomiting than remimazolam-alfentanil during hysteroscopy: a single-centre randomized controlled trial
by: Xiaoqiang Zhang, et al.
Published: (2023-06-01)
by: Xiaoqiang Zhang, et al.
Published: (2023-06-01)
Sedative effect of remimazolam combined with alfentanil in colonoscopic polypectomy: a prospective, randomized, controlled clinical trial
by: Yueyang Xin, et al.
Published: (2022-08-01)
by: Yueyang Xin, et al.
Published: (2022-08-01)
Pharmacodynamics study of remimazolam besylate in anxious patients undergoing gastroscopy: a biased-coin design up-and-down sequential allocation trial
by: Bao-Zhu Cha, et al.
Published: (2025-07-01)
by: Bao-Zhu Cha, et al.
Published: (2025-07-01)
The 90% effective dose (ED90) of remimazolam for inhibiting responses to the insertion of a duodenoscope during ERCP
by: Yan Guo, et al.
Published: (2024-05-01)
by: Yan Guo, et al.
Published: (2024-05-01)
Sedation for Colonoscopy: Comparison of Remifentanil and Alfentanil Combined with Propofol/Midazolam
by: Şule Arıcan, et al.
Published: (2019-11-01)
by: Şule Arıcan, et al.
Published: (2019-11-01)
The influence of sex on the dosage of remimazolam co-administered with remifentanil for loss of consciousness in adult patients: an up-and-down sequential allocation trial
by: Juyeon Oh, et al.
Published: (2024-08-01)
by: Juyeon Oh, et al.
Published: (2024-08-01)
Randomized double-blind comparison of remifentanil and alfentanil in patients undergoing laparoscopic cholecystectomy using total intravenous anesthesia
by: José M Belena, et al.
Published: (2016-01-01)
by: José M Belena, et al.
Published: (2016-01-01)
Effective doses of alfentanil combined with propofol for gastroscopy in patients of different ages under Narcotrend monitoring: a prospective dose-finding study utilizing the up-and-down sequential allocation method
by: Lili Jiang, et al.
Published: (2025-09-01)
by: Lili Jiang, et al.
Published: (2025-09-01)
Determination of the 50% and 95% Effective Dose of Remimazolam Combined with Propofol for Intravenous Sedation During Day-Surgery Hysteroscopy
by: Tan H, et al.
Published: (2023-06-01)
by: Tan H, et al.
Published: (2023-06-01)
The effects of a propofol/alfentanil admixture on total intravenous anaesthesia in dogs undergoing splenectomy
by: N. Jia, et al.
Published: (2015-04-01)
by: N. Jia, et al.
Published: (2015-04-01)
Comparison of the Safety and Efficacy of Remimazolam Besylate versus Dexmedetomidine for Patients Undergoing Fiberoptic Bronchoscopy: A Prospective, Randomized Controlled Trial
by: Xu H, et al.
Published: (2024-06-01)
by: Xu H, et al.
Published: (2024-06-01)
Cardiopulmonary Adverse Events of Remimazolam versus Propofol During Cervical Conization: A Randomized Controlled Trial
by: Wang L, et al.
Published: (2023-04-01)
by: Wang L, et al.
Published: (2023-04-01)
Patient-controlled sedation with propofol/remifentanil versus propofol/alfentanil for patients undergoing outpatient colonoscopy, a randomized, controlled double-blind study
by: Sherif S Sultan
Published: (2014-01-01)
by: Sherif S Sultan
Published: (2014-01-01)
The Impact of Fentanyl on the Effective Dose of Remimazolam-Induced Sedation in Elderly Female Patients: An Up-and-Down Sequential Allocation Trial
by: Huang XD, et al.
Published: (2024-08-01)
by: Huang XD, et al.
Published: (2024-08-01)
Determining the 90% Effective Dose of Remimazolam to Prevent Physical Movement in Surgical Abortions: A Biased-Coin Up-and-Down Sequential Allocation Trial
by: Fang F, et al.
Published: (2025-07-01)
by: Fang F, et al.
Published: (2025-07-01)
The safety and efficacy of alfentanil combined with midazolam in fiberoptic bronchoscopy sedation: A randomized, double-blind, controlled trial
by: Longfei Wang, et al.
Published: (2022-10-01)
by: Longfei Wang, et al.
Published: (2022-10-01)
Successful sedation with remimazolam and alfentanil in a child susceptible to malignant hyperthermia: a case report
by: Kailai Zhu, et al.
Published: (2025-04-01)
by: Kailai Zhu, et al.
Published: (2025-04-01)
Anestesia geral com propofol em cães pré-tratados com acepromazina e alfentanil General anesthesia with propofol in dogs premedicated with acepromazine and alfentanil
by: Silvia Renata Gaido Cortopassi, et al.
Published: (2000-08-01)
by: Silvia Renata Gaido Cortopassi, et al.
Published: (2000-08-01)
The ED50 and ED95 of remimazolam tosilate to inhibit the gastroscopy reaction in elderly patients of varying ages: an up-and-down sequential allocation trial
by: Yang Yang, et al.
Published: (2025-05-01)
by: Yang Yang, et al.
Published: (2025-05-01)
Profile of Remimazolam in Anesthesiology: A Narrative Review of Clinical Research Progress
by: Wang M, et al.
Published: (2022-10-01)
by: Wang M, et al.
Published: (2022-10-01)
Safety and effcacy of remimazolam tosilate for sedation during combined spinal-epidural anesthesia for orthopedic procedures: a randomized controlled trial
by: Yufei Chen, et al.
Published: (2024-02-01)
by: Yufei Chen, et al.
Published: (2024-02-01)
Intravenous Anesthesia with Ciprofol and Remimazolam Besylate for Painless Gastroscopy: A Prospective, Single-Center, Randomized Controlled Trial
by: Li L, et al.
Published: (2025-09-01)
by: Li L, et al.
Published: (2025-09-01)
Laryngeal edema following remimazolam-induced anaphylaxis: a rare clinical manifestation
by: Xiawei Hu, et al.
Published: (2023-03-01)
by: Xiawei Hu, et al.
Published: (2023-03-01)
Effect of Fentanyl on Remimazolam-Induced Sedation in Female Patients Undergoing Hysteroscopic Surgery: A Randomized Controlled Trial
by: Huang XD, et al.
Published: (2025-02-01)
by: Huang XD, et al.
Published: (2025-02-01)
Remimazolam in children: a comprehensive narrative review
by: Tom G. Hansen, et al.
Published: (2025-02-01)
by: Tom G. Hansen, et al.
Published: (2025-02-01)
Influences of Propofol, Ciprofol and Remimazolam on Dreaming During Anesthesia for Gastrointestinal Endoscopy: A Randomized Double-Blind Parallel-Design Trial
by: Zhou R, et al.
Published: (2024-05-01)
by: Zhou R, et al.
Published: (2024-05-01)
INTUBATIONS CONDITIONS AND HOMODYNAMIC RESPONSES UNDER ANESTHESIA INDUCTION WITH THREE COMBINATION DRUGS: ALFENTANIL- MIDAZOLAM, ALFENTANIL- THIOPENTAL AND ALFENTANIL- KETAMINE
by: H SOLTANI NEZHAD, et al.
Published: (2000-03-01)
by: H SOLTANI NEZHAD, et al.
Published: (2000-03-01)
Low-Dose Alfentanil Inhibits Sufentanil-Induced Cough During Anesthesia Induction: A Prospective, Randomized, Double-Blind Study
by: Xu Q, et al.
Published: (2024-05-01)
by: Xu Q, et al.
Published: (2024-05-01)
Remimazolam, a novel drug, for safe and effective endoscopic sedation
by: Jae Min Lee, et al.
Published: (2025-05-01)
by: Jae Min Lee, et al.
Published: (2025-05-01)
Safety and efficacy of a low-dose combination of midazolam, alfentanil, and propofol for deep sedation of elderly patients undergoing ERCP
by: Yanping Zhang, et al.
Published: (2024-04-01)
by: Yanping Zhang, et al.
Published: (2024-04-01)
Target-controlled infusion of remimazolam effect-site concentration for total intravenous anesthesia in patients undergoing minimal invasive surgeries
by: Jin Young Chon, et al.
Published: (2024-04-01)
by: Jin Young Chon, et al.
Published: (2024-04-01)
Utilização de alfentanil, sufentanil e fentanil em cães anestesiados com halotano Use of alfentanil, sufentanil and fentanyl in dogs anesthetized with halothane
by: Denise Tabacchi Fantoni, et al.
Published: (1999-12-01)
by: Denise Tabacchi Fantoni, et al.
Published: (1999-12-01)
Clinical Application and Research Progress of Remimazolam for Pediatric Patients
by: Bai C, et al.
Published: (2024-04-01)
by: Bai C, et al.
Published: (2024-04-01)
The safety and efficacy of remimazolam, ciprofol, and propofol anesthesia in endoscopy: a systematic review and network meta-analysis
by: Siqi Zhou, et al.
Published: (2025-05-01)
by: Siqi Zhou, et al.
Published: (2025-05-01)
Determination of the 95% effective dose of remimazolam to achieve loss of consciousness during anesthesia induction in different age groups
by: Juyeon Oh, et al.
Published: (2022-12-01)
by: Juyeon Oh, et al.
Published: (2022-12-01)
The Median Effective Dose and Bispectral Index of Remimazolam Tosilate for Anesthesia Induction in Elderly Patients: An Up-and-Down Sequential Allocation Trial
by: Liu M, et al.
Published: (2022-05-01)
by: Liu M, et al.
Published: (2022-05-01)
Efficacy and Safety Profile of Remimazolam for Sedation in Adults Undergoing Short Surgical Procedures
by: Morimoto Y
Published: (2022-02-01)
by: Morimoto Y
Published: (2022-02-01)
Similar Items
-
Alfentanil Enhanced the Sedation of Remimazolam During Anaesthesia Induction in Patients Undergoing Urological Day Surgery: A Randomised Controlled Trial
by: Lin Y, et al.
Published: (2025-07-01) -
Moderate sedation by total intravenous remimazolam-alfentanil vs. propofol-alfentanil for third molar extraction: A prospective randomized controlled trial
by: Nan Zhao, et al.
Published: (2022-09-01) -
Determination of ED50 and ED95 of remimazolam besylate combined with alfentanil for adult gastroscopy: a prospective dose-finding study
by: Pingjuan Wang, et al.
Published: (2024-07-01) -
Remimazolam-remifentanil causes less postoperative nausea and vomiting than remimazolam-alfentanil during hysteroscopy: a single-centre randomized controlled trial
by: Xiaoqiang Zhang, et al.
Published: (2023-06-01) -
Sedative effect of remimazolam combined with alfentanil in colonoscopic polypectomy: a prospective, randomized, controlled clinical trial
by: Yueyang Xin, et al.
Published: (2022-08-01)
