Hemolytic uremic syndrome in the setting of COVID-19 successfully treated with complement inhibition therapy: An instructive case report of a previously healthy toddler and review of literature
IntroductionAs the global pandemic continues, new complications of COVID-19 in pediatric population have turned up, one of them being hemolytic uremic syndrome (HUS), a complement-mediated thrombotic microangiopathy (CM-TMA) characterized by triad of thrombocytopenia, microangiopathic hemolytic anem...
| Published in: | Frontiers in Pediatrics |
|---|---|
| Main Authors: | Matija Matošević, Ivanka Kos, Maša Davidović, Maja Ban, Hana Matković, Ivan Jakopčić, Ivana Vuković Brinar, Ágnes Szilágyi, Dorottya Csuka, György Sinkovits, Zoltán Prohászka, Kristina Vrljičak, Lovro Lamot |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1092860/full |
Similar Items
Pregnancy in Complement-Mediated Thrombotic Microangiopathy: Maternal and Neonatal OutcomesPlain Language Summary
by: Natalja Haninger-Vacariu, et al.
Published: (2023-07-01)
by: Natalja Haninger-Vacariu, et al.
Published: (2023-07-01)
Editorial: Cystic kidney diseases in children and adults: from diagnosis to etiology and back
by: Lovro Lamot, et al.
Published: (2024-04-01)
by: Lovro Lamot, et al.
Published: (2024-04-01)
A case of hemolytic uremic syndrome following hysterosalpingiogram
by: Ahmed Mohamed Elhawy, et al.
Published: (2025-09-01)
by: Ahmed Mohamed Elhawy, et al.
Published: (2025-09-01)
Hemolytic uremic syndrome: Toxins, vessels, and inflammation
by: Howard eTrachtman
Published: (2014-11-01)
by: Howard eTrachtman
Published: (2014-11-01)
Validation of Early Increase in Complement Activation Marker sC5b-9 as a Predictive Biomarker for the Development of Thrombotic Microangiopathy After Stem Cell Transplantation
by: Blanka Mezö, et al.
Published: (2020-10-01)
by: Blanka Mezö, et al.
Published: (2020-10-01)
Use of complement C5-inhibitor eculizumab in patients with infection-associated hemolytic uremic syndrome – a case-series report
by: Petra Varga, et al.
Published: (2025-03-01)
by: Petra Varga, et al.
Published: (2025-03-01)
Single-Center Experience of Pediatric Cystic Kidney Disease and Literature Review
by: Sara Grlić, et al.
Published: (2024-03-01)
by: Sara Grlić, et al.
Published: (2024-03-01)
Eculizumab is efficacious and safe in pediatric patients with various forms of hemolytic uremic syndrome: a retrospective clinical experience of a tertiary center
by: Naama Lax, et al.
Published: (2025-04-01)
by: Naama Lax, et al.
Published: (2025-04-01)
Atypical Hemolytic Uremic Syndrome: Differential Diagnosis from TTP/HUS and Management
by: Mustafa N. Yenerel
Published: (2014-08-01)
by: Mustafa N. Yenerel
Published: (2014-08-01)
Typical course of cystinuria leading to untypical complications in pregnancy: A case report and review of literature
by: Ema Ivandic, et al.
Published: (2023-04-01)
by: Ema Ivandic, et al.
Published: (2023-04-01)
Thrombotic microangiopathy in children: Redefining hemolytic uremic syndrome, thrombotic thrombocytopenic purpura and related disorders
by: Mamta Manglani, et al.
Published: (2024-03-01)
by: Mamta Manglani, et al.
Published: (2024-03-01)
Neurological Manifestations of Hemolytic Uremic Syndrome: A Comprehensive Review
by: Una Tonkovic, et al.
Published: (2025-07-01)
by: Una Tonkovic, et al.
Published: (2025-07-01)
Predicting autosomal dominant polycystic kidney disease progression: review of promising Serum and urine biomarkers
by: Iva Sorić Hosman, et al.
Published: (2023-11-01)
by: Iva Sorić Hosman, et al.
Published: (2023-11-01)
HELLP Syndrome and Differential Diagnosis with Other Thrombotic Microangiopathies in Pregnancy
by: Stefano Raffaele Giannubilo, et al.
Published: (2024-02-01)
by: Stefano Raffaele Giannubilo, et al.
Published: (2024-02-01)
Clinical value of the renal pathologic scoring system in complement-mediated thrombotic microangiopathy
by: Fei-Fei Chen, et al.
Published: (2023-12-01)
by: Fei-Fei Chen, et al.
Published: (2023-12-01)
Application of eculizumab, a terminal complement inhibitor, in the management of atypical hemolytic uremic syndrome in a 14-month-old Chinese pediatric patient: a case report
by: Xin Wei, et al.
Published: (2024-07-01)
by: Xin Wei, et al.
Published: (2024-07-01)
Pregnancy-Associated Atypical Hemolytic Uremic Syndrome: A Case Report with <i>MCP</i> Gene Mutation and Successful Eculizumab Treatment
by: Alex Domínguez-Vargas, et al.
Published: (2024-01-01)
by: Alex Domínguez-Vargas, et al.
Published: (2024-01-01)
PLASMIC score to aid diagnosis of aHUS: an analysis of C5 inhibitor clinical trials and the PINC AI™ healthcare database
by: Miguel G. Uriol-Rivera, et al.
Published: (2025-05-01)
by: Miguel G. Uriol-Rivera, et al.
Published: (2025-05-01)
A Multicenter Study Evaluating the Discontinuation of Eculizumab Therapy in Children with Atypical Hemolytic Uremic Syndrome
by: Saeed AlZabali, et al.
Published: (2022-11-01)
by: Saeed AlZabali, et al.
Published: (2022-11-01)
Two sides of the same coin: a complex presentation of autosomal dominant tubulointerstitial kidney diseases: a literature review and case reports
by: Margareta Fistrek Prlic, et al.
Published: (2023-11-01)
by: Margareta Fistrek Prlic, et al.
Published: (2023-11-01)
Annual trends in atypical haemolytic uremic syndrome management in Japan and factors influencing early diagnosis and treatment: a retrospective study
by: Yoshitaka Tatematsu, et al.
Published: (2024-08-01)
by: Yoshitaka Tatematsu, et al.
Published: (2024-08-01)
Pediatric Atypical Hemolytic Uremic Syndrome Advances
by: Rupesh Raina, et al.
Published: (2021-12-01)
by: Rupesh Raina, et al.
Published: (2021-12-01)
Camptodactyly and Clinodactyly – New Understanding of Known Deformities
by: Matija Matošević, et al.
Published: (2021-01-01)
by: Matija Matošević, et al.
Published: (2021-01-01)
The outcome of thrombotic microangiopathy in kidney transplant recipients
by: Kanza Haq, et al.
Published: (2024-11-01)
by: Kanza Haq, et al.
Published: (2024-11-01)
Living with Atypical Hemolytic Uremic Syndrome in the Netherlands: Patient and Family Perspective
by: Romy N. Bouwmeester, et al.
Published: (2024-07-01)
by: Romy N. Bouwmeester, et al.
Published: (2024-07-01)
Association of thrombotic microangiopathy with interferon therapy for hepatitis B: a case report
by: Shan Wei, et al.
Published: (2024-07-01)
by: Shan Wei, et al.
Published: (2024-07-01)
Real-world outcomes of spinal muscular atrophy treatment with onasemnogene abeparvovec in Croatia: a comprehensive case series and literature review
by: Ivan Lehman, et al.
Published: (2025-06-01)
by: Ivan Lehman, et al.
Published: (2025-06-01)
Pseudo-Thrombotic Microangiopathy (Pseudo-TMA): a rare manifestation of vitamin B12 deficiency in a child
by: Mohd Arif, et al.
Published: (2025-06-01)
by: Mohd Arif, et al.
Published: (2025-06-01)
Practical approach to thrombocytopenia in patients with sepsis: a narrative review
by: Kasumi Satoh, et al.
Published: (2024-07-01)
by: Kasumi Satoh, et al.
Published: (2024-07-01)
Cathelicidin in Urinary Tract Diseases: Diagnostic, Prognostic and Therapeutic Potential of an Evolutionary Conserved Antimicrobial Protein
by: Iva Sorić Hosman, et al.
Published: (2024-12-01)
by: Iva Sorić Hosman, et al.
Published: (2024-12-01)
Mixed Retinopathy: A Unique Presentation
by: Pushkar Dhir, et al.
Published: (2019-04-01)
by: Pushkar Dhir, et al.
Published: (2019-04-01)
Drug-induced de novo thrombotic microangiopathy diagnosed 2 years after renal transplantation: a case report and literature review
by: Keisuke Ozaki, et al.
Published: (2023-01-01)
by: Keisuke Ozaki, et al.
Published: (2023-01-01)
Eculizumab Treatment for Postpartum HELLP Syndrome and aHUS—Case Report
by: A. Inkeri Lokki, et al.
Published: (2020-04-01)
by: A. Inkeri Lokki, et al.
Published: (2020-04-01)
Ex vivo C5b-9 Deposition Test to Monitor Complement Activity in Clinical and Subclinical Atypical Hemolytic Uremic Syndrome and in Transplantation-Associated Thrombotic Microangiopathy
by: Maria Martin, et al.
Published: (2024-07-01)
by: Maria Martin, et al.
Published: (2024-07-01)
Thrombotic microangiopathy multidisciplinary assessment team: demographics, final diagnosis, treatment, and outcomes
by: Matthew Nguyen, et al.
Published: (2025-09-01)
by: Matthew Nguyen, et al.
Published: (2025-09-01)
Delayed Onset of Thrombotic Microangiopathy (TMA) upon Prolonged Carfilzomib Therapy in Multiple Myeloma: A Case Report and Comprehensive Review
by: Andrea Ceglédi, et al.
Published: (2024-12-01)
by: Andrea Ceglédi, et al.
Published: (2024-12-01)
Case report: Successful treatment of renal-limited thrombotic microangiopathy secondary to chronic lymphocytic leukemia
by: Kristina Nasr, et al.
Published: (2024-08-01)
by: Kristina Nasr, et al.
Published: (2024-08-01)
A case of hemolytic-uremic syndrome that developed in a 5-year-old child due to acute intestinal infection with hemocolitis
by: O. V. Molochkova, et al.
Published: (2024-03-01)
by: O. V. Molochkova, et al.
Published: (2024-03-01)
Effect of blood groups on acquired and congenital thrombotic thrombocytopenic purpura and clinical correlation: Multi-center Turkish cohort study
by: Cevat İlteriş Kıkılı, et al.
Published: (2025-01-01)
by: Cevat İlteriş Kıkılı, et al.
Published: (2025-01-01)
Bevacizumab-Induced Thrombotic Microangiopathy (TMA) in Metastatic Lung Adenocarcinoma Patients Receiving Nivolumab Combined with Bevacizumab, Carboplatin and Paclitaxel: Two Case Reports
by: Ping-Chih Hsu, et al.
Published: (2023-01-01)
by: Ping-Chih Hsu, et al.
Published: (2023-01-01)
Similar Items
-
Pregnancy in Complement-Mediated Thrombotic Microangiopathy: Maternal and Neonatal OutcomesPlain Language Summary
by: Natalja Haninger-Vacariu, et al.
Published: (2023-07-01) -
Editorial: Cystic kidney diseases in children and adults: from diagnosis to etiology and back
by: Lovro Lamot, et al.
Published: (2024-04-01) -
A case of hemolytic uremic syndrome following hysterosalpingiogram
by: Ahmed Mohamed Elhawy, et al.
Published: (2025-09-01) -
Hemolytic uremic syndrome: Toxins, vessels, and inflammation
by: Howard eTrachtman
Published: (2014-11-01) -
Validation of Early Increase in Complement Activation Marker sC5b-9 as a Predictive Biomarker for the Development of Thrombotic Microangiopathy After Stem Cell Transplantation
by: Blanka Mezö, et al.
Published: (2020-10-01)
