Diuretic activity of 3-(5-bromfuran-2-yl)-4-r-(4h)-1,2,4-triazole-5-thione, their S-derivatives and 2-(5-bromfuran-2-yl)-5-r'-thiazolo[3,2-b][1,2,4]triazole-6(5h)-ones

• 发表在: Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki
• Main Authors: Ye. S. Pruglo, A. S. Gotsulya, O. I. Panasenko, Ye. G. Knysh
• 格式: 文件
• 语言: 英语
• 出版: Zaporizhzhia State Medical and Pharmaceutical University 2015-12-01
• 主题: Diuretic Effect; 1 2 4-triazole; Side Effects; Adverse Reactions
• 在线阅读: http://pharmed.zsmu.edu.ua/article/view/52274/49788
• ISSN: 2306-8094; 2409-2932

The aim of study was to investigate diuretic activity of 1,2,4-triazole derivatives which contain С5 atom 5-bromfuran-2-yl substituent in the 1,2,4-triazole nucleus, and to establish interrelation between chemical structure and diuretic action of 1,2,4-triazole derivatives. Methods and results. For the investigation of the diuretic activity were used 15 compounds, namely 3-(5-bromofuran-2-yl)-4-R-(4H)-1,2,4-triazole-5-thiones, their S-derivatives and 2-(5-bromofuran-2-yl)-5-R'-thiazolo[3,2-b][1,2,4]triazole-6(5H)-ones. During the study Ye. B. Berkhin’s method has been used to establish the influence of the compounds on the renal excretory function. Conclusion. The most active substance among 1,2,4-triazole derivatives was morpholinium 2-((5-bromofuran-2-yl)-4-ethyl-1,2,4-triazole-3-ylthio)acetate.