Ubiquitin is a versatile scaffold protein for the generation of molecules withde novo binding and advantageous drug‐like properties
In the search for effective therapeutic strategies, protein‐based biologicals are under intense development. While monoclonal antibodies represent the majority of these drugs, other innovative approaches are exploring the use of scaffold proteins for the creation of binding molecules with tailor‐mad...
| Published in: | FEBS Open Bio |
|---|---|
| Main Authors: | Florian Job, Florian Settele, Susan Lorey, Chris Rundfeldt, Lars Baumann, Annette G. Beck-Sickinger, Ulrich Haupts, Hauke Lilie, Eva Bosse-Doenecke |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.fob.2015.07.002 |
Similar Items
Differential expression of SDF-1 receptor CXCR4 in molecularly defined forms of inherited thrombocytopenias
by: Juan P. Salim, et al.
Published: (2017-08-01)
by: Juan P. Salim, et al.
Published: (2017-08-01)
High expression of CXCR4, CXCR7 and SDF-1 predicts poor survival in renal cell carcinoma
by: Wang Linhui, et al.
Published: (2012-10-01)
by: Wang Linhui, et al.
Published: (2012-10-01)
Zoledronate interrupts pre-osteoclast-induced angiogenesis via SDF-1/CXCR4 pathway
by: Mohamed Awad, et al.
Published: (2024-12-01)
by: Mohamed Awad, et al.
Published: (2024-12-01)
Activation of CXCR7 exerts an inhibitory effect on adipogenesis through regulation of β-arrestin2/Wnt and AKT signalling
by: Shiyue Sun, et al.
Published: (2025-12-01)
by: Shiyue Sun, et al.
Published: (2025-12-01)
Deletion of SDF-1 or CXCR4 regulates platelet activation linked to glucose metabolism and mitochondrial respiratory reserve
by: Yi Li, et al.
Published: (2022-05-01)
by: Yi Li, et al.
Published: (2022-05-01)
DIPEPTIDYL PEPTIDASE-4 REGULATION OF SDF-1/CXCR4 AXIS: IMPLICATIONS FOR CARDIOVASCULAR DISEASE
by: Jixin eZhong, et al.
Published: (2015-09-01)
by: Jixin eZhong, et al.
Published: (2015-09-01)
SDF-1α/CXCR4 Axis Mediates The Migration of Mesenchymal Stem Cells to The Hypoxic-Ischemic Brain Lesion in A Rat Model
by: Qin Yu, et al.
Published: (2015-01-01)
by: Qin Yu, et al.
Published: (2015-01-01)
SDF-1/CXCL12 and CXCR4 gene variants, and elevated serum SDF-1 levels are associated with preeclampsia
by: Savas Karakus, et al.
Published: (2017-04-01)
by: Savas Karakus, et al.
Published: (2017-04-01)
Clinical and prognostic relevance of CXCL12 expression in acute myeloid leukemia
by: Shi-sen Wang, et al.
Published: (2021-07-01)
by: Shi-sen Wang, et al.
Published: (2021-07-01)
Mechanism of Bushen Zhuangjin Decoction to Promote BMSCs Homing and Protect Articular Cartilage in Mice by the SDF-1/CXCR4 Axis
by: HUANG Yanfeng, et al.
Published: (2024-02-01)
by: HUANG Yanfeng, et al.
Published: (2024-02-01)
The story of clobenpropit and CXCR4: can be an effective drug in cancer and autoimmune diseases?
by: Mitra Abbasifard, et al.
Published: (2024-07-01)
by: Mitra Abbasifard, et al.
Published: (2024-07-01)
Involvement of CXCR4 in Normal and Abnormal Development
by: Nanako Kawaguchi, et al.
Published: (2019-02-01)
by: Nanako Kawaguchi, et al.
Published: (2019-02-01)
Stromal Cell-Derived Factor 1 Protects Brain Vascular Endothelial Cells from Radiation-Induced Brain Damage
by: Jong-Ik Heo, et al.
Published: (2019-10-01)
by: Jong-Ik Heo, et al.
Published: (2019-10-01)
SOCS3 inhibits the mesenchymal stromal cell secretory factor SDF-1-mediated improvement of islet function in non-obese diabetic mice
by: Mingxing Sui, et al.
Published: (2023-07-01)
by: Mingxing Sui, et al.
Published: (2023-07-01)
Hypoxia-induced the upregulation of stromal cell-derived factor 1 in fibroblast-like synoviocytes contributes to migration of monocytes into synovium tissue in rheumatoid arthritis
by: Ru Yang, et al.
Published: (2018-02-01)
by: Ru Yang, et al.
Published: (2018-02-01)
Effects of stachydrine on podocyte injury in diabetic nephropathy rats by regulating the SDF-1/CXCR4 signaling pathway
by: Tong Ai-ping, et al.
Published: (2025-06-01)
by: Tong Ai-ping, et al.
Published: (2025-06-01)
Association of SDF1 and MMP12 with Atherosclerosis and Inflammation: Clinical and Experimental Study
by: María Marcos-Jubilar, et al.
Published: (2021-05-01)
by: María Marcos-Jubilar, et al.
Published: (2021-05-01)
Association of SDF-1 and its receptor CXCR4 polymorphisms on the susceptibility of diabetic retinopathy in the Taiwanese population
by: Shu-Yen Peng, et al.
Published: (2023-11-01)
by: Shu-Yen Peng, et al.
Published: (2023-11-01)
BMP9 maintains the phenotype of HTR-8/Svneo trophoblast cells by activating the SDF1/CXCR4 pathway
by: Xue Yang, et al.
Published: (2023-08-01)
by: Xue Yang, et al.
Published: (2023-08-01)
VEGFR1-tyrosine kinase signaling in pulmonary fibrosis
by: Hideki Amano, et al.
Published: (2021-06-01)
by: Hideki Amano, et al.
Published: (2021-06-01)
Co-delivery of sorafenib and metapristone encapsulated by CXCR4-targeted PLGA-PEG nanoparticles overcomes hepatocellular carcinoma resistance to sorafenib
by: Ning Zheng, et al.
Published: (2019-05-01)
by: Ning Zheng, et al.
Published: (2019-05-01)
The effect of DPP-4 inhibition to improve functional outcome after stroke is mediated by the SDF-1α/CXCR4 pathway
by: Fausto Chiazza, et al.
Published: (2018-05-01)
by: Fausto Chiazza, et al.
Published: (2018-05-01)
Potential Role of CXCR4 Targeting in the Context of Radiotherapy and Immunotherapy of Cancer
by: Franziska Eckert, et al.
Published: (2018-12-01)
by: Franziska Eckert, et al.
Published: (2018-12-01)
Baicalin promotes apoptosis and inhibits proliferation and migration of hypoxia-induced pulmonary artery smooth muscle cells by up-regulating A2a receptor via the SDF-1/CXCR4 signaling pathway
by: Xiaoying Huang, et al.
Published: (2018-12-01)
by: Xiaoying Huang, et al.
Published: (2018-12-01)
Extracellular Ubiquitin Enhances Autophagy and Inhibits Mitochondrial Apoptosis Pathway to Protect Neurons Against Spinal Cord Ischemic Injury via CXCR4
by: Hao Feng, et al.
Published: (2025-03-01)
by: Hao Feng, et al.
Published: (2025-03-01)
An Evaluation of CXCR4 Targeting with PAMAM Dendrimer Conjugates for Oncologic Applications
by: Wojciech G. Lesniak, et al.
Published: (2022-03-01)
by: Wojciech G. Lesniak, et al.
Published: (2022-03-01)
Overexpression of Nrf2 in bone marrow mesenchymal stem cells promotes B-cell acute lymphoblastic leukemia cells invasion and extramedullary organ infiltration through stimulation of the SDF-1/CXCR4 axis
by: Lin Zheng, et al.
Published: (2024-07-01)
by: Lin Zheng, et al.
Published: (2024-07-01)
Correction: Overexpression of Nrf2 in bone marrow mesenchymal stem cells promotes B-cell acute lymphoblastic leukemia cells invasion and extramedullary organ infiltration through stimulation of the SDF-1/CXCR4 axis
by: Lin Zheng, et al.
Published: (2025-08-01)
by: Lin Zheng, et al.
Published: (2025-08-01)
Modeling the SDF-1/CXCR4 protein using advanced artificial intelligence and antagonist screening for Japanese anchovy
by: Issei Yahiro, et al.
Published: (2024-02-01)
by: Issei Yahiro, et al.
Published: (2024-02-01)
Endothelial cell-derived MMP19 promotes pulmonary fibrosis by inducing E(nd)MT and monocyte infiltration
by: Weiming Zhao, et al.
Published: (2023-03-01)
by: Weiming Zhao, et al.
Published: (2023-03-01)
Role of SDF-1/CXCR4 in cancer-associated fibroblasts
by: YU Biao, LIU Qing, WU Xiao-ming
Published: (2020-09-01)
by: YU Biao, LIU Qing, WU Xiao-ming
Published: (2020-09-01)
Silibinin efficacy in a rat model of pulmonary arterial hypertension using monocrotaline and chronic hypoxia
by: Tingting Zhang, et al.
Published: (2019-04-01)
by: Tingting Zhang, et al.
Published: (2019-04-01)
OTUB1-mediated inhibition of ubiquitination: a growing list of effectors, multiplex mechanisms, and versatile functions
by: Miaomiao Wu, et al.
Published: (2024-01-01)
by: Miaomiao Wu, et al.
Published: (2024-01-01)
Targeting the Ubiquitin–Proteasome System for Cancer
by: Zhaoyun Liu, et al.
Published: (2025-10-01)
by: Zhaoyun Liu, et al.
Published: (2025-10-01)
A static magnetic field enhances the repair of osteoarthritic cartilage by promoting the migration of stem cells and chondrogenesis
by: Yuting Sun, et al.
Published: (2023-03-01)
by: Yuting Sun, et al.
Published: (2023-03-01)
Correlation between SDF-1α, CD34 positive hematopoietic stem cells and CXCR4 expression with liver fibrosis in CCl4 rat model
by: Sara Abubakr, et al.
Published: (2023-09-01)
by: Sara Abubakr, et al.
Published: (2023-09-01)
Danhong Injection Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells in Myocardial Infarction by Promoting Angiogenesis
by: Jingrui Chen, et al.
Published: (2018-07-01)
by: Jingrui Chen, et al.
Published: (2018-07-01)
Saikosaponin A Inhibits Triple-Negative Breast Cancer Growth and Metastasis Through Downregulation of CXCR4
by: Ying Wang, et al.
Published: (2020-01-01)
by: Ying Wang, et al.
Published: (2020-01-01)
High co-expression of the SDF1/CXCR4 axis in hepatocarcinoma cells is regulated by AnnexinA7 in vitro and in vivo
by: Jingwen Wang, et al.
Published: (2018-05-01)
by: Jingwen Wang, et al.
Published: (2018-05-01)
Tibial cortex transverse transport potentiates diabetic wound healing via activation of SDF-1/CXCR4 signaling
by: Shuanji Ou, et al.
Published: (2023-09-01)
by: Shuanji Ou, et al.
Published: (2023-09-01)
Similar Items
-
Differential expression of SDF-1 receptor CXCR4 in molecularly defined forms of inherited thrombocytopenias
by: Juan P. Salim, et al.
Published: (2017-08-01) -
High expression of CXCR4, CXCR7 and SDF-1 predicts poor survival in renal cell carcinoma
by: Wang Linhui, et al.
Published: (2012-10-01) -
Zoledronate interrupts pre-osteoclast-induced angiogenesis via SDF-1/CXCR4 pathway
by: Mohamed Awad, et al.
Published: (2024-12-01) -
Activation of CXCR7 exerts an inhibitory effect on adipogenesis through regulation of β-arrestin2/Wnt and AKT signalling
by: Shiyue Sun, et al.
Published: (2025-12-01) -
Deletion of SDF-1 or CXCR4 regulates platelet activation linked to glucose metabolism and mitochondrial respiratory reserve
by: Yi Li, et al.
Published: (2022-05-01)
