Myricetin alleviated hydrogen peroxide-induced cellular senescence of nucleus pulposus cell through regulating SERPINE1

Abstract Background Myricetin (MYR) is a common plant flavonoid with antioxidant and anticancer properties. However, the anti-aging effect of MYR on nucleus pulposus cells (NPCs) is still unknown. The study aimed to explore the effect of MYR on the senescence of NPCs. Methods Methyl-thiazolyl tetraz...

Full description

Bibliographic Details
Published in:	Journal of Orthopaedic Surgery and Research
Main Authors:	Rongsheng Chen, Xiaobo Zhang, Xitian Zhu, Changsheng Wang, Weihong Xu
Format:	Article
Language:	English
Published:	BMC 2023-02-01
Subjects:	Myricetin Senescence Nucleus pulposus cells SERPINE1
Online Access:	https://doi.org/10.1186/s13018-022-03463-0

Similar Items

Myricetin alleviates H2O2-induced senescence and apoptosis in rat nucleus pulposus-derived mesenchymal stem cells
by: Tian Xie, et al.
Published: (2023-07-01)

Homoplantaginin exerts therapeutic effects on intervertebral disc degeneration by alleviating TNF-α-induced nucleus pulposus cell senescence and inflammation
by: Jiadong Guo, et al.
Published: (2025-03-01)

Co-culturing nucleus pulposus mesenchymal stem cells with notochordal cell-rich nucleus pulposus explants attenuates tumor necrosis factor-α-induced senescence
by: Xiao-Chuan Li, et al.
Published: (2018-06-01)

RETRACTED ARTICLE: Psoralen synergizes with exosome-loaded SPC25 to alleviate senescence of nucleus pulposus cells in intervertebral disc degeneration
by: Lei Yang, et al.
Published: (2023-10-01)

Ruxolitinib Delays Nucleus Pulposus Cell Senescence in Rat Intervertebral Discs
by: Honggang Hao, et al.
Published: (2025-03-01)

Morroniside attenuates nucleus pulposus cell senescence to alleviate intervertebral disc degeneration via inhibiting ROS-Hippo-p53 pathway
by: Chengcong Zhou, et al.
Published: (2022-09-01)

Effect of High Glucose on Stress-Induced Senescence of Nucleus Pulposus Cells of Adult Rats
by: Jae-Gwan Kong, et al.
Published: (2015-04-01)

Polymeric hydrogels and decellularized nucleus pulposus extracellular matrix technology for nucleus pulposus repair and regeneration
by: Xuan Peng, et al.
Published: (2023-01-01)

STMN1–IGFBP5 axis induces senescence and extracellular matrix degradation in nucleus pulposus cells: In vivo and in vitro insights
by: Lei Li, et al.
Published: (2025-05-01)

High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway
by: Pei Li, et al.
Published: (2017-09-01)

Machine learning-enabled identification of nucleus pulposus senescence-associated genes as potential biomarkers for intervertebral disc degeneration
by: Min Xiang, et al.
Published: (2025-09-01)

Eupatilin attenuates the senescence of nucleus pulposus cells and mitigates intervertebral disc degeneration via inhibition of the MAPK/NF-κB signaling pathway
by: Huan Yang, et al.
Published: (2022-11-01)

Biomimetic Hydrogels for In Vitro Modelling of Nucleus Pulposus Degeneration: Effects of Extracellular Matrix Compositional Change on Physicochemical Properties and Cell Phenotype
by: Narjes Rashidi, et al.
Published: (2025-07-01)

The regulatory mechanism of cyclic GMP-AMP synthase on inflammatory senescence of nucleus pulposus cell
by: Rui Sun, et al.
Published: (2024-07-01)

Effects of Hsa-miR-4741/LILRB2 on Senescence of Nucleus Pulposus Cells and Their Prognostic Values in Lumbar Disc Herniation
by: Zhendong He, et al.
Published: (2025-12-01)

Targeted Inhibition of cGAS/STING signaling induced by aberrant R-Loops in the nucleus pulposus to alleviate cellular senescence and intervertebral disc degeneration
by: Dan Wu, et al.
Published: (2025-07-01)

Hydrogen sulfide regulates autophagy in nucleus pulposus cells under hypoxia
by: Lei Yue, et al.
Published: (2021-12-01)

N-Cadherin Attenuates High Glucose-Induced Nucleus Pulposus Cell Senescence Through Regulation of the ROS/NF-κB Pathway
by: Gang Hou, et al.
Published: (2018-05-01)

Study on the effeets of hypoxia on the level of OCN in nucleus pulposus cells
by: WU Yuanmin, et al.
Published: (2015-04-01)

Optimization of Spheroid Colony Culture and Cryopreservation of Nucleus Pulposus Cells for the Development of Intervertebral Disc Regenerative Therapeutics
by: Kosuke Sako, et al.
Published: (2021-04-01)

Herniated Nucleus Pulposus in Dr. Hasan Sadikin General Hospital Bandung Indonesia
by: Annisa Ikhsanawati, et al.
Published: (2015-06-01)

Harmonization and standardization of nucleus pulposus cell extraction and culture methods
by: Shaghayegh Basatvat, et al.
Published: (2023-03-01)

Ubiquitination-mediated PRDX2 alleviates intervertebral disc degeneration via restraining TBHP-induced nucleus pulposus cell apoptosis, ferroptosis and ECM degradation
by: Fanguo Kong, et al.
Published: (2026-03-01)

MANAJEMEN NYERI PASIEN RAWAT JALAN PADA KASUS HERNIA NUKLEUS PULPOSUS MELALUI CORE STABILITY
by: Elsa Roselina, et al.
Published: (2014-06-01)

Inducing Angiogenesis in the Nucleus Pulposus
by: Sheela R. Damle, et al.
Published: (2023-10-01)

A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration
by: Chang Liu, et al.
Published: (2020-02-01)

CircSPG21 ameliorates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells and mitigates intervertebral disc degeneration through the miR-217/SIRT1 axis and mitophagy
by: Yongbo Zhang, et al.
Published: (2025-02-01)

Single-cell sequencing reveals cellular heterogeneity of nucleus pulposus in intervertebral disc degeneration
by: Shu Jia, et al.
Published: (2024-11-01)

A step‐by‐step protocol for isolation of murine nucleus pulposus cells
by: Andrew Bratsman, et al.
Published: (2019-12-01)

Exosomes derived from senescent skeletal muscle cells aggravate nucleus pulposus cell metabolic dysregulation via p38MAPK pathway for promoting intervertebral disc degeneration
by: Xiaowei Ma, et al.
Published: (2026-04-01)

Muscone suppresses inflammation and senescence of nucleus pulposus via p53 signalling during intervertebral disc degeneration
by: Ruizhe Wang, et al.
Published: (2025-08-01)

Bottom-up engineering of the nucleus pulposus using a photocrosslinkable decellularized matrix hydrogel attenuates inflammaging and enhances microtissue-mediated regeneration
by: Xiaoxiao Li, et al.
Published: (2025-12-01)

Immune exposure: how macrophages interact with the nucleus pulposus
by: Peng Feng, et al.
Published: (2023-04-01)

Scutellarin reduces apoptosis of nucleus pulposus cells in intervertebral disc degeneration of rat models
by: LI Na, ZHANG Peng, ZHANG Nan, LIN Wei, LIU Defeng, ZHENG Jihui
Published: (2025-09-01)

Getting to the Core: Exploring the Embryonic Development from Notochord to Nucleus Pulposus
by: Luca Ambrosio, et al.
Published: (2024-07-01)

The effectiveness and safety of a percutaneous controllable curved plasma radiofrequency ablation device of nucleus pulposus
by: Hao ZHOU, et al.
Published: (2025-08-01)

Bag-1 Protects Nucleus Pulposus Cells from Oxidative Stress by Interacting with HSP70
by: Kaori Suyama, et al.
Published: (2023-03-01)

Osmotic adaptation of nucleus pulposus cells: the role of aquaporin 1, aquaporin 4 and transient receptor potential vanilloid 4
by: JW Snuggs, et al.
Published: (2021-02-01)

Gene expression profiling in nucleus pulposus of human ruptured lumbar disc herniation
by: Xiaochun Li, et al.
Published: (2022-11-01)

Aquaporin-3 Attenuates Oxidative Stress-Induced Nucleus Pulposus Cell Apoptosis Through Regulating the P38 MAPK Pathway
by: Yichun Xu, et al.
Published: (2018-11-01)