Peptide Linker Affecting the Activity Retention Rate of VHH in Immunosorbents
VHH-based immunosorbents are an emerging and promising tool for the removal of toxic substances from plasma. However, the small size of VHHs is a double-edged sword, bringing both benefits and drawbacks to the immunosorbent. The small size of the VHH allows a higher coupling density, while the close...
| Published in: | Biomolecules |
|---|---|
| Main Authors: | Da Li, Jun Ren, Fangling Ji, Qiang Peng, Hu Teng, Lingyun Jia |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-11-01
|
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/10/12/1610 |
Similar Items
One-step Preparation of a VHH-based Immunoadsorbent for the Extracorporeal Removal of β2-microglobulin
by: Lijun Zhang, et al.
Published: (2019-06-01)
by: Lijun Zhang, et al.
Published: (2019-06-01)
Flavouring Group Evaluation 80, Revision 2 (FGE.80Rev2): Consideration of alicyclic, alicyclic‐fused and aromatic‐fused ring lactones evaluated by the JECFA (61st and 82nd meetings) structurally related to an aromatic lactone evaluated in FGE.27
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2024-08-01)
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2024-08-01)
Flavouring Group Evaluation 21 Revision 6 (FGE.21Rev6): thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2023-02-01)
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2023-02-01)
Switching Between Bicyclic and Linear Peptides — The Sulfhydryl-Specific Linker TPSMB Enables Reversible Cyclization of Peptides
by: Christoph Ernst, et al.
Published: (2018-10-01)
by: Christoph Ernst, et al.
Published: (2018-10-01)
Antibody–drug conjugates: Recent advances in linker chemistry
by: Zheng Su, et al.
Published: (2021-12-01)
by: Zheng Su, et al.
Published: (2021-12-01)
Design of an in vivo cleavable disulfide linker in recombinant fusion proteins
by: Xiaoying Chen, et al.
Published: (2010-07-01)
by: Xiaoying Chen, et al.
Published: (2010-07-01)
Flavouring Group Evaluation 217 Revision 3 (FGE.217Rev3): consideration of genotoxic potential for α,β‐unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: lactones
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2023-04-01)
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2023-04-01)
Characteristic roadmap of linker governs the rational design of PROTACs
by: Yawen Dong, et al.
Published: (2024-10-01)
by: Yawen Dong, et al.
Published: (2024-10-01)
Structure-Guided Stapling of Dimeric Conformations and Linker Engineering Enhance Thermostability and Fine-Tune Activity of Bispecific VHH Cytokine Agonists
by: Raphael Trenker, et al.
Published: (2025-09-01)
by: Raphael Trenker, et al.
Published: (2025-09-01)
Scientific Opinion on Flavouring Group Evaluation 201 Revision 2 (FGE.201Rev2): 2‐alkylated, aliphatic, acyclic alpha,beta‐unsaturated aldehydes and precursors, with or without additional double‐bonds, from chemical subgroup 1.1.2 of FGE.19
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2018-10-01)
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2018-10-01)
Development of naïve phage display VHH libraries from Indian camel
by: L DASH, et al.
Published: (2016-08-01)
by: L DASH, et al.
Published: (2016-08-01)
Flavouring group evaluation 420 (FGE.420): Hesperetin dihydrochalcone
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2024-12-01)
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2024-12-01)
Impact of Linker Modification and PEGylation of Vancomycin Conjugates on Structure-Activity Relationships and Pharmacokinetics
by: Florian Umstätter, et al.
Published: (2022-01-01)
by: Florian Umstätter, et al.
Published: (2022-01-01)
SpyDirect: A Novel Biofunctionalization Method for High Stability and Longevity of Electronic Biosensors
by: Keying Guo, et al.
Published: (2024-07-01)
by: Keying Guo, et al.
Published: (2024-07-01)
Chomsky’s (2020) Links and linker phenomena
by: M. Rita Manzini
Published: (2021-09-01)
by: M. Rita Manzini
Published: (2021-09-01)
Assessments of the In Vitro and In Vivo Linker Stability and Catabolic Fate for the Ortho Hydroxy-Protected Aryl Sulfate Linker by Immuno-Affinity Capture Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometric Assay
by: Byeong ill Lee, et al.
Published: (2021-01-01)
by: Byeong ill Lee, et al.
Published: (2021-01-01)
5-Fluorouracil-β-Cyclodextrin conjugates:Linker strategies to enhance the anticancer efficacy and reduce the side effects
by: Liangliang Hu, et al.
Published: (2025-03-01)
by: Liangliang Hu, et al.
Published: (2025-03-01)
MNase Digestion Protection Patterns of the Linker DNA in Chromatosomes
by: Chang-Hui Shen, et al.
Published: (2021-08-01)
by: Chang-Hui Shen, et al.
Published: (2021-08-01)
Scientific Opinion on Flavouring Group Evaluation 67 Revision 2 (FGE.67Rev2): Consideration of 28 furan‐substituted compounds evaluated by JECFA at the 55th, 65th and 69th meetings (JECFA, 2001, 2006a, 2009b)
by: EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
Published: (2015-05-01)
by: EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
Published: (2015-05-01)
Scientific opinion on Flavouring group evaluation 216 revision 2 (FGE.216Rev2): consideration of the genotoxicity potential of α,β‐unsaturated 2‐phenyl‐2‐alkenals from subgroup 3.3 of FGE.19
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2022-08-01)
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2022-08-01)
Neutralizing VHH Antibodies Targeting the Spike Protein of PEDV
by: Li Zhang, et al.
Published: (2024-11-01)
by: Li Zhang, et al.
Published: (2024-11-01)
Safety-Catch Linkers for Solid-Phase Peptide Synthesis
by: Sikabwe Noki, et al.
Published: (2024-03-01)
by: Sikabwe Noki, et al.
Published: (2024-03-01)
Scientific Opinion on Flavouring Group Evaluation 7, Revision 6 (FGE.07Rev6): saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched‐chain carboxylic acids from chemical group 5
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2022-02-01)
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2022-02-01)
Research advances in peptide‒drug conjugates
by: Liming Gong, et al.
Published: (2023-09-01)
by: Liming Gong, et al.
Published: (2023-09-01)
Peptide–Drug Conjugates as Next-Generation Therapeutics: Exploring the Potential and Clinical Progress
by: Krishna Jadhav, et al.
Published: (2025-04-01)
by: Krishna Jadhav, et al.
Published: (2025-04-01)
Effect of the Neck Linker on Processive Stepping of Kinesin Motor
by: Ping Xie
Published: (2023-01-01)
by: Ping Xie
Published: (2023-01-01)
A Computationally Guided Approach to Improve Expression of VHH Binders
by: Emine Sila Ozdemir, et al.
Published: (2024-11-01)
by: Emine Sila Ozdemir, et al.
Published: (2024-11-01)
Nanobody-Based Indirect Competitive ELISA for Sensitive Detection of 19-Nortestosterone in Animal Urine
by: Yuan-yuan Yang, et al.
Published: (2021-01-01)
by: Yuan-yuan Yang, et al.
Published: (2021-01-01)
Applications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions
by: Michael Mullin, et al.
Published: (2024-12-01)
by: Michael Mullin, et al.
Published: (2024-12-01)
Scientific Opinion on Flavouring Group Evaluation 67, Revision 1 (FGE.67Rev.1): Consideration of 40 furan‐substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b) and re‐evaluated at the 69th meeting (JECFA, 2009c)
by: EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
Published: (2011-10-01)
by: EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
Published: (2011-10-01)
Flavouring Group Evaluation 76 Revision 2 (FGE.76Rev2): Consideration of sulfur‐containing heterocyclic compounds, evaluated by JECFA, structurally related to thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev5
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2023-02-01)
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2023-02-01)
The abscence of the linker in double object constructions in Nuu
by: Chris Collins
Published: (2004-06-01)
by: Chris Collins
Published: (2004-06-01)
Actin-membrane linkers: Insights from synthetic reconstituted systems
by: Feng-Ching Tsai, et al.
Published: (2024-06-01)
by: Feng-Ching Tsai, et al.
Published: (2024-06-01)
A nanobody-based blocking enzyme-linked immunosorbent assay for detecting antibodies against pseudorabies virus glycoprotein E
by: Huanhuan Lü, et al.
Published: (2024-04-01)
by: Huanhuan Lü, et al.
Published: (2024-04-01)
Peptide–drug conjugates (PDCs): a novel trend of research and development on targeted therapy, hype or hope?
by: Chen Fu, et al.
Published: (2023-02-01)
by: Chen Fu, et al.
Published: (2023-02-01)
Scientific opinion on Flavouring Group Evaluation 25, Revision 3 (FGE.25Rev3): Aliphatic hydrocarbons from chemical group 31
by: EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
Published: (2015-04-01)
by: EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
Published: (2015-04-01)
Scientific Opinion on Flavouring Group Evaluation 208 Revision 2 (FGE.208Rev2): Consideration of genotoxicity data on alicyclic aldehydes with α,β‐unsaturation in ring/side‐chain and precursors from chemical subgroup 2.2 of FGE.19
by: EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF), et al.
Published: (2017-05-01)
by: EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF), et al.
Published: (2017-05-01)
Linker-mediated oriented antibody immobilisation strategies for a more efficient immunosensor and diagnostic applications: A review
by: Shin Yi Gan, et al.
Published: (2023-09-01)
by: Shin Yi Gan, et al.
Published: (2023-09-01)
Phosphate-Based Self-Immolative Linkers for the Delivery of Amine-Containing Drugs
by: Mateja Đud, et al.
Published: (2021-08-01)
by: Mateja Đud, et al.
Published: (2021-08-01)
Interleukin 21-Armed EGFR-VHH-CAR-T Cell Therapy for the Treatment of Esophageal Squamous Cell Carcinoma
by: Chenglin Zhang, et al.
Published: (2025-06-01)
by: Chenglin Zhang, et al.
Published: (2025-06-01)
Similar Items
-
One-step Preparation of a VHH-based Immunoadsorbent for the Extracorporeal Removal of β2-microglobulin
by: Lijun Zhang, et al.
Published: (2019-06-01) -
Flavouring Group Evaluation 80, Revision 2 (FGE.80Rev2): Consideration of alicyclic, alicyclic‐fused and aromatic‐fused ring lactones evaluated by the JECFA (61st and 82nd meetings) structurally related to an aromatic lactone evaluated in FGE.27
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2024-08-01) -
Flavouring Group Evaluation 21 Revision 6 (FGE.21Rev6): thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30
by: EFSA Panel on Food Additives and Flavourings (FAF), et al.
Published: (2023-02-01) -
Switching Between Bicyclic and Linear Peptides — The Sulfhydryl-Specific Linker TPSMB Enables Reversible Cyclization of Peptides
by: Christoph Ernst, et al.
Published: (2018-10-01) -
Antibody–drug conjugates: Recent advances in linker chemistry
by: Zheng Su, et al.
Published: (2021-12-01)
