Psilocybin in the treatment of obsessive-compulsive disorder: What do we know so far?

Introduction Psilocybin is a naturally occurring plant alkaloid in mushrooms and a prodrug of psilocin. It is a serotonin receptor (5-HT2A) agonist and known psychedelic, with similar hallucinatory properties to lysergic acid diethylamide (LSD). It has been identified as a safe and effective optio...

Full description

Bibliographic Details
Published in:	European Psychiatry
Main Authors:	N. Descalço, A.B. Medeiros, C. Fernandes Santos, G. Borges
Format:	Article
Language:	English
Published:	Cambridge University Press 2021-04-01
Subjects:	Obsessive-Compulsive disorder Psilocybin Hallucinogens
Online Access:	https://www.cambridge.org/core/product/identifier/S0924933821011147/type/journal_article

Similar Items

Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder: A case report
by: Benjamin Kelmendi, et al.
Published: (2022-12-01)

Unlocking the healing power of psilocybin: an overview of the role of psilocybin therapy in major depressive disorder, obsessive-compulsive disorder and substance use disorder
by: Sandra Szafoni, et al.
Published: (2024-06-01)

Safety, tolerability, and clinical and neural effects of single-dose psilocybin in obsessive–compulsive disorder: protocol for a randomized, double-blind, placebo-controlled, non-crossover trial
by: Terence H. W. Ching, et al.
Published: (2023-04-01)

Single-dose (10 mg) psilocybin reduces symptoms in adults with obsessive-compulsive disorder: A pharmacological challenge study
by: Luca Pellegrini, et al.
Published: (2025-10-01)

Knowledge, attitudes, and concerns about psilocybin and MDMA as novel therapies among U.S. healthcare professionals
by: Erin Wang, et al.
Published: (2024-11-01)

Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings
by: Terence H. W. Ching, et al.
Published: (2024-01-01)

Corrigendum: Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings
by: Terence H. W. Ching, et al.
Published: (2024-02-01)

Understanding obsessive-compulsive disorder - literature review
by: Laura Piasek, et al.
Published: (2023-08-01)

Obsessive-Compulsive Disorder and suicide: what do we know up until now?
by: G. Salvadori, et al.
Published: (2022-06-01)

Naturalistic psilocybin use is associated with persisting improvements in mental health and wellbeing: results from a prospective, longitudinal survey
by: Sandeep M. Nayak, et al.
Published: (2023-09-01)

Somatic delusions and obsessive-compulsive disorder in schizophrenia
by: Arnold C. Lawrence, et al.
Published: (2010-12-01)

Symptoms Analysis of Obsessive–Compulsive Disorder in Adolescents and Adults in a Teaching Hospital
by: Bharat Kumar Goit, et al.
Published: (2014-06-01)

Psilocybin sex-dependently reduces alcohol consumption in C57BL/6J mice
by: Kenneth Alper, et al.
Published: (2023-01-01)

Childhood-Onset Obsessive Compulsive Disorder
by: Murat Erdem, et al.
Published: (2011-06-01)

Clinical features of and influencing factors of obsessive-compulsive personality disorder in patients with obsessive-compulsive disorder
by: Jiang Wenjing, et al.
Published: (2024-08-01)

The specific pattern of obsessive-compulsive symptoms in patients with bipolar disorder
by: Arash Alizadeh, et al.
Published: (2008-04-01)

Obsessive-compulsive disorder presenting with compulsions to urinate frequently
by: Stephen Amarjeet Jiwanmall, et al.
Published: (2016-01-01)

Boundaries between compulsive buying and hoarding regarding the obsessive-compulsive spectrum
by: L. Moreno, et al.
Published: (2021-04-01)

Evaluation Of Impulsivity Symptoms And Family Functioning In Adolescents Diagnosed With Obsessive Compulsive Disorder And Their Mothers
by: Gonca Ozyurt
Published: (2016-08-01)

Obsessive compulsive disorder with pervasive avoidance
by: Sharma Parul, et al.
Published: (2009-01-01)

Validation of the short version of the obsessive compulsive spectrum questionnaire
by: Liliana Dell’Osso, et al.
Published: (2023-06-01)

Investigation of the effectiveness of psychodrama on improving obsessive-compulsive symptoms and anger in patients with obsessive-compulsive disorder
by: Melina Shirani Bidabadi, et al.
Published: (2022-05-01)

Obsessive-compulsive Symptoms in Dementia : Scooping Review of Neurobiological and Cognitive Underpinnings
by: F. Martinho, et al.
Published: (2022-06-01)

The Role of Obsessive Compulsive Traits in Fibromyalgia: Is Pain-Related Obsessive Ideation Involved in Pathogenesis?
by: Bat-El Lugassy-Galper, et al.
Published: (2024-06-01)

Obsessive-Compulsive Disorder, Sexual Obsessions and Sexual (Dys) Function: A Narrative Review
by: L Pereira Ferreira, et al.
Published: (2021-07-01)

The relationship between Facebook attachment and obsessive-compulsive disorder severity
by: Soon-Li Lee, et al.
Published: (2015-07-01)

Clinical characteristics of obsessive-compulsive disorder comorbid with obsessive -compulsive personality disorder: subtype implications
by: Ayse Dondu, et al.
Published: (2025-07-01)

Clinical Challenges in Pedophilia-Themed Obsessive-Compulsive Disorder
by: Carla Ferreira, et al.
Published: (2021-10-01)

Effects of comorbid obsessive-compulsive personality disorder on the behavioral inhibition/activation systems in patients with obsessive-compulsive disorder
by: ZHOU Jinjing, et al.
Published: (2025-03-01)

Obsessive Compulsive Disorder with Poor Insight
by: Serkut Bulut, et al.
Published: (2014-06-01)

Metacognitive Model of Obsessive Compulsive Disorder
by: Pinar Yoruk, et al.
Published: (2015-06-01)

Obsessive compulsive disorder masquerading as psychosis
by: Dhanya Raveendranathan, et al.
Published: (2012-01-01)

Methylphenidate-Induced Obsessive-Compulsiveness
by: J Gordon Millichap
Published: (1998-02-01)

The Prevalence of Obsessive-Compulsive Disorder Symptoms and the Influential Factors in COVID-19 Patients in Kurdistan, Iran
by: Karo Servatyari, et al.
Published: (2024-02-01)

Comparison Of Metacognitions Between Obsessive Compulsive Disorder’s Subtypes And Normal Healthy Controls
by: Katre DOĞAN, et al.
Published: (2013-03-01)

The Role of N-Acetylcysteine in Obsessive-Compulsive (OCD) and Related Disorders
by: J. Sá Couto, et al.
Published: (2022-06-01)

Which antipsychotics can we use for obsessive-compulsive symptoms in schizophrenia?
by: A. Aissa, et al.
Published: (2021-04-01)

Exploring the structure of the university-students obsessive–compulsive tendency scale in Iranian university students: a network analysis study
by: Mohammadreza Davoudi, et al.
Published: (2023-09-01)

Effects of Family and Patient Oriented Educational Program on the Symptoms of Patients with Obsessive-Compulsive Disorder
by: Tahereh Heidari, et al.
Published: (2020-05-01)

Comparison of Metacognitions Between Obsessive Compulsive Disorders Subtypes and Normal Healthy Controls
by: Katre DOÐAN, et al.
Published: (2013-04-01)