Characterization of the proteome of stable and unstable carotid atherosclerotic plaques using data-independent acquisition mass spectrometry

Abstract Background Currently, noninvasive imaging techniques and circulating biomarkers are still insufficient to accurately assess carotid plaque stability, and an in-depth understanding of the molecular mechanisms that contribute to plaque instability is still lacking. Methods We established a cl...

Full description

Bibliographic Details
Published in:	Journal of Translational Medicine
Main Authors:	Zhichao Lai, Chaonan Wang, Xiaoyan Liu, Haidan Sun, Zhengguang Guo, Jiang Shao, Kang Li, Junye Chen, Jiaxian Wang, Xiangling Lei, Keqiang Shu, Yuyao Feng, Deqiang Kong, Wei Sun, Bao Liu
Format:	Article
Language:	English
Published:	BMC 2024-03-01
Subjects:	Carotid artery stenosis Unstable carotid plaque Proteomic Ferroptosis
Online Access:	https://doi.org/10.1186/s12967-023-04723-1

Similar Items

Characteristics of Unstable Carotid Plaques – New Image Modalities
by: Peycheva Marieta V., et al.
Published: (2019-03-01)

BIOMARKERS FOR UNSTABLE ATHEROSCLEROTIC PLAQUES IN CAROTID ARTERIES
by: M. Peycheva, et al.
Published: (2019-09-01)

Identification of hub genes and regulatory networks in histologically unstable carotid atherosclerotic plaque by bioinformatics analysis
by: Julong Guo, et al.
Published: (2022-06-01)

Carotid plaque characteristics by computed Tomography: A diagnostic accuracy systematic review
by: David Pakizer, et al.
Published: (2025-06-01)

Association Between Triglyceride–Glucose Index and Carotid Plaque Stability in Different Glycemic Status: A Single‐Center Retrospective Study
by: Guijun Huo, et al.
Published: (2025-02-01)

The utility of ultrasound and computed tomography in the assessment of carotid artery plaque vulnerability–A mini review
by: Aniruddha Singh, et al.
Published: (2022-11-01)

Correlation between Carotid Atherosclerotic Plaques and Acute Ischemic Stroke
by: Qin ZAN, et al.
Published: (2023-01-01)

Structure of carotid sinus atherosclerotic plaques and disturbances of cerebral blood circulation
by: T. S. Gulevskaja, et al.
Published: (2017-02-01)

Features of the atherosclerotic plaque microbiome in patients after carotid endarterectomy
by: E. P. Kolesova, et al.
Published: (2025-01-01)

Molecular landscape of atherosclerotic plaque progression: insights from proteomics, single-cell transcriptomics and genomics
by: Chaonan Wang, et al.
Published: (2025-05-01)

YKL-40 Is Associated With Ultrasound-Determined Carotid Atherosclerotic Plaque Instability
by: Yu Wang, et al.
Published: (2021-02-01)

Update on diagnostic approach of carotid disease: From stenosis to atherosclerotic plaque morphology
by: Alfredo Montenegro, et al.
Published: (2021-12-01)

Echographic features of the structure of atherosclerotic plaques in carotid ischemic stroke
by: A. Yu. Vishnyakova, et al.
Published: (2020-04-01)

Role of 18F-FDG positron emission tomography in carotid atherosclerotic plaque imaging: A systematic review
by: Reddy Ravikanth
Published: (2020-10-01)

Determinants of carotid intima-media thickness in patients with asymptomatic unstable plaques: a population-based cross-sectional study in rural China
by: Ping Tang, et al.
Published: (2025-07-01)

Ultrasound signs of atherosclerotic plaques destabilization in carotid arteries
by: D. E. Zaitsev, et al.
Published: (2019-12-01)

Geometric changes and clinical risk factors from aortic arch to proximal internal carotid artery between normal subjects and moderate right carotid plaques
by: Dac Hong An Ngo, et al.
Published: (2024-08-01)

Association of Sleep Duration With Incident Carotid Plaque: A Prospective Cohort Study
by: Meijie Chen, et al.
Published: (2025-05-01)

Persistent Asthma Is Associated With Carotid Plaque in MESA
by: Matthew C. Tattersall, et al.
Published: (2022-12-01)

Optoacoustic biomarkers of lipids, hemorrhage and inflammation in carotid atherosclerosis
by: Angelos Karlas, et al.
Published: (2023-11-01)

Association Between Carotid Artery Small Plaque on Computed Tomography Angiography and Embolic Stroke of Undetermined Source
by: Junpei Nagasawa, et al.
Published: (2025-09-01)

Multimodality imaging of carotid atherosclerotic plaque: Going beyond stenosis
by: Divyata Hingwala, et al.
Published: (2013-01-01)

Identification of immune cell infiltration and diagnostic biomarkers in unstable atherosclerotic plaques by integrated bioinformatics analysis and machine learning
by: Jing Wang, et al.
Published: (2022-09-01)

PATHOPHYSIOLOGICAL ASPECTS OF INFLAMMATORY REACTION IN DIFFERENT TYPES OF ATHEROSCLEROTIC PLAQUES OF CAROTID ARTERIES
by: V. Yu. Mikhailichenko, et al.
Published: (2016-03-01)

Risk factors for hypoechoic carotid plaque in healthy physical-examination population
by: Meng Fu, et al.
Published: (2024-09-01)

Composition of carotid plaques differs between Chinese and US patients: a histology study
by: Jingli Cao, et al.
Published: (2025-10-01)

Carotid geometry is independently associated with complicated carotid artery plaques
by: Christoph Strecker, et al.
Published: (2023-06-01)

Research Progress on the Risk Factors and Outcomes of Human Carotid Atherosclerotic Plaques
by: Xiang-Dong Xiong, et al.
Published: (2017-01-01)

Association of systolic blood pressure time in target range with carotid atherosclerotic plaque and carotid intima-media thickness in hypertensive patients
by: Wen Li, et al.
Published: (2025-05-01)

A Threshold Study of Carotid Plaque Risk in Postmenopausal Middle-aged Women with Normal Homocysteine
by: LU Ran, WU Chunyan, XU Haina, AN Miaomiao, WU Baoqin, LAI Jun, RAN Limei
Published: (2024-04-01)

Plaque vulnerability in patients with high- and moderate-grade carotid stenosis – comparison of plaque features on MRI with histopathological findings
by: Pascal Tapis, et al.
Published: (2020-02-01)

Identification Markers of Carotid Vulnerable Plaques: An Update
by: Yilin Wang, et al.
Published: (2022-08-01)

The study on risk assessment of carotid plaques in the Northern Chinese population based on LASSO regression
by: Kun Yuan, et al.
Published: (2025-05-01)

Atherosclerotic plaque in carotid arteries as a risk marker for cardiovascular events risk in middle aged population
by: A. I. Ershova, et al.
Published: (2018-08-01)

DualPlaqueNet with dual-branch structure and attention mechanism for carotid plaque semantic segmentation and size prediction
by: Lili Deng, et al.
Published: (2025-07-01)

Characteristics of the gut microbiota of patients with symptomatic carotid atherosclerotic plaques positive for bacterial genetic material
by: Hang Lv, et al.
Published: (2024-01-01)

Oxidative Stress as a Reliable Biomarker of Carotid Plaque Instability: A Pilot Study
by: Norbert Svoboda, et al.
Published: (2023-02-01)

Nomogram and Carotid Risk Score for Predicting Moderate or High Carotid Atherosclerosis among Asymptomatic Elderly Recycling Volunteers
by: Cheng-Lun Hsiao, et al.
Published: (2022-06-01)

Association analysis of the triglyceride-glucose index with carotid atherosclerotic plaques
by: Shuping CHEN, et al.
Published: (2025-06-01)

Geometric consistency among atherosclerotic plaques in carotid arteries evaluated by multidimensional parameters
by: Ling Li, et al.
Published: (2024-09-01)