Asymptomatic T-cell large granular lymphocyte leukemia with an unusual immunophenotype

T-cell large granular lymphocyte (T-LGL) leukemia represents a clonal proliferation of cytotoxic T-cells which etiology has not been entirely elucidated. However, CD4+, CD4–,CD8–, CD4+, CD8+ cases have been described. The disease is usually characterized by cytopenias and a modest lymphocytosis. The...

Full description

Bibliographic Details
Published in:Clinics and Practice
Main Authors: Panagiota K. Petsa, Achilleas Karamoutsios, Lefkothea Dova, Leonidas Benetatos, Asimina Petsiou, Nikolaos Kolaitis, Antonis Georgopoulos, Georgios Vartholomatos
Format: Article
Language:English
Published: MDPI AG 2012-06-01
Subjects:
large granular lymphocytes
T-LGL leukemia
T cell receptor
flow cytometry.
Online Access:https://www.clinicsandpractice.org/index.php/cp/article/view/320
Description
Summary:T-cell large granular lymphocyte (T-LGL) leukemia represents a clonal proliferation of cytotoxic T-cells which etiology has not been entirely elucidated. However, CD4+, CD4–,CD8–, CD4+, CD8+ cases have been described. The disease is usually characterized by cytopenias and a modest lymphocytosis. The majority of patients with T-LGL leukemia remains asymptomatic for a long period and will require treatment later during the course of their disease. Hereby we describe a case of T-LGL leukemia diagnosed by flow cytometry, which presented indolent course and required no treatment so far.
ISSN:2039-7275
2039-7283

Similar Items