Ablation of lipocalin-2 reduces neuroinflammation in a mouse model of Krabbe disease

Abstract Lipocalin-2 (LCN2) is an acute-phase secretory molecule significantly upregulated in various neuroinflammatory and demyelinating conditions. Krabbe disease (KD) is a neurodegenerative lysosomal disorder caused by a galactosylceramidase (GALC) deficiency, accumulating cytotoxic psychosine in...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Jacob Favret, Malabika Maulik, Rayan Masoom, Meghana Kushwaha, Devin Thompson, Richard Browne, Daesung Shin
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-12-01
Subjects:	Lysosomal storage disorder Krabbe disease Globoid cell leukodystrophy Galactosylceramidase Psychosine Lipocalin-2
Online Access:	https://doi.org/10.1038/s41598-024-82927-1