Screening of selective histone deacetylase inhibitors by proteochemometric modeling

<p>Abstract</p> <p>Background</p> <p>Histone deacetylase (HDAC) is a novel target for the treatment of cancer and it can be classified into three classes, i.e., classes I, II, and IV. The inhibitors selectively targeting individual HDAC have been proved to be the better...

書誌詳細
出版年:	BMC Bioinformatics
主要な著者:	Wu Dingfeng, Huang Qi, Zhang Yida, Zhang Qingchen, Liu Qi, Gao Jun, Cao Zhiwei, Zhu Ruixin
フォーマット:	論文
言語:	英語
出版事項:	BMC 2012-08-01
主題:	Histone deacetylases inhibitors Proteochemometric Selective inhibitors
オンライン･アクセス:	http://www.biomedcentral.com/1471-2105/13/212

類似資料

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma
著者:: Monica Phimmachanh, 等
出版事項: (2020-10-01)

Design, synthesis, and biological evaluation of novel histone deacetylase 6 selective inhibitors
著者:: Tianyi Zhang, 等
出版事項: (2022-05-01)

Histone deacetylase inhibitors
著者:: Marzena Baran, 等
出版事項: (2020-08-01)

Histone Deacetylases and their Inhibitors in Cancer Epigenetics
著者:: Kelly N. Hassell
出版事項: (2019-11-01)

Role of histone deacetylase inhibitors in non-neoplastic diseases
著者:: Chunxiao Zhou, 等
出版事項: (2024-07-01)

Histone Deacetylases and Their Isoform-Specific Inhibitors in Ischemic Stroke
著者:: Svetlana Demyanenko, 等
出版事項: (2021-10-01)

Advanced Progress of Histone Deacetylases in Rheumatic Diseases
著者:: Liu XM, 等
出版事項: (2024-02-01)

Finding the molecular scaffold of nuclear receptor inhibitors through high-throughput screening based on proteochemometric modelling
著者:: Tianyi Qiu, 等
出版事項: (2018-04-01)

Exploring the role of histone deacetylase and histone deacetylase inhibitors in the context of multiple myeloma: mechanisms, therapeutic implications, and future perspectives
著者:: Jingjing Pu, 等
出版事項: (2024-04-01)

Advances in non-Hydroxamate based Histone Deacetylase Inhibitors as Anticancer Agents
著者:: Nadine W. Nabiha, 等
出版事項: (2024-06-01)

Role of histone deacetylases and their inhibitors in neurological diseases
著者:: Li-Ying Zhang, 等
出版事項: (2024-10-01)

The application of histone deacetylases inhibitors in glioblastoma
著者:: Rui Chen, 等
出版事項: (2020-07-01)

Discovery of potent histone deacetylase inhibitors with modified phenanthridine caps
著者:: Wenli Fan, 等
出版事項: (2021-01-01)

The Process and Strategy for Developing Selective Histone Deacetylase 3 Inhibitors
著者:: Fangyuan Cao, 等
出版事項: (2018-03-01)

Histone Deacetylases Inhibitors in Neurodegenerative Diseases, Neuroprotection and Neuronal Differentiation
著者:: Surabhi Shukla, 等
出版事項: (2020-04-01)

Research Progress on the Mechanism of Histone Deacetylases in Ferroptosis of Glioma
著者:: Meng Ma, 等
出版事項: (2024-08-01)

Zinc binding groups for histone deacetylase inhibitors
著者:: Lei Zhang, 等
出版事項: (2018-01-01)

Advances in targeting histone deacetylase for treatment of solid tumors
著者:: Mu-Qi Shi, 等
出版事項: (2024-05-01)

Targeted inhibition of histone deacetylase 6 in inflammatory diseases
著者:: Jie Ran, 等
出版事項: (2019-03-01)

Novel Histone Deacetylase Inhibitors and HIV-1 Latency-Reversing Agents Identified by Large-Scale Virtual Screening
著者:: Donya Naz Divsalar, 等
出版事項: (2020-06-01)

Role of Histone Deacetylase 6 and Histone Deacetylase 6 Inhibition in Colorectal Cancer
著者:: Ana Vuletić, 等
出版事項: (2023-12-01)

Epigenetic Regulation of Host Defense Peptide Synthesis: Synergy Between Histone Deacetylase Inhibitors and DNA/Histone Methyltransferase Inhibitors
著者:: Melanie A. Whitmore, 等
出版事項: (2022-04-01)

The Impact of Fluorination on the Design of Histone Deacetylase Inhibitors
著者:: Duong Tien Anh, 等
出版事項: (2023-02-01)

Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury
著者:: Hitoshi Uchida, 等
出版事項: (2015-08-01)

Improved Anticancer Activities of a New Pentafluorothio-Substituted Vorinostat-Type Histone Deacetylase Inhibitor
著者:: Nils Goehringer, 等
出版事項: (2021-12-01)

Histone Deacetylase Inhibitors and Microtubule Inhibitors Induce Apoptosis in Feline Luminal Mammary Carcinoma Cells
著者:: Filipe Almeida, 等
出版事項: (2021-02-01)

Targeting histone deacetylase in cardiac diseases
著者:: Jiao Lu, 等
出版事項: (2024-06-01)

Thermal shift engagement assay for Class IIA histone deacetylase inhibitor screening
著者:: Lauren N. Kotsull, 等
出版事項: (2025-11-01)

In silico profiling of histone deacetylase inhibitory activity of compounds isolated from Cajanus cajan
著者:: Kayode Adewole, 等
出版事項: (2022-01-01)

Histone deacetylases facilitate the accurate repair of broken forks
著者:: Belén Gómez-González, 等
出版事項: (2020-03-01)

Design and synthesis of thiazole-based hydroxamate histone deacetylase inhibitors with potent antitumor efficacy by inducing apoptosis, pyroptosis and cell cycle arrest
著者:: Zhijian Li, 等
出版事項: (2025-07-01)

Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy
著者:: Dan-Feng Cao, 等
出版事項: (2024-11-01)

Novel histone deacetylase-5 inhibitor T2943 exerts an anti-depressive effect in mice by enhancing GRID1 expression
著者:: Juan Du, 等
出版事項: (2025-02-01)

A review of the therapeutic potential of histone deacetylase inhibitors in rhabdomyosarcoma
著者:: Omar Selim, 等
出版事項: (2023-08-01)

Quantitative Acetylomics Uncover Acetylation-Mediated Pathway Changes Following Histone Deacetylase Inhibition in Anaplastic Large Cell Lymphoma
著者:: Maša Zrimšek, 等
出版事項: (2022-08-01)

Non-Hydroxamate Zinc-Binding Groups as Warheads for Histone Deacetylases
著者:: Anton Frühauf, 等
出版事項: (2021-08-01)

Combination Therapy with Immune Checkpoint Inhibitors and Histone Deacetylase Inhibitors or Alkylating Agents
著者:: Joerger M, 等
出版事項: (2024-07-01)

Histone Deacetylase Inhibitor Alleviates the Neurodegenerative Phenotypes and Histone Dysregulation in Presenilins-Deficient Mice
著者:: Ting Cao, 等
出版事項: (2018-05-01)

Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention
著者:: Dusan Ruzic, 等
出版事項: (2022-01-01)

Histone Deacetylase 4 Inhibition Reduces Rotenone-Induced Alpha-Synuclein Accumulation via Autophagy in SH-SY5Y Cells
著者:: Luxi Wang, 等
出版事項: (2023-04-01)