Circulating Biomarkers Reflecting Destabilization Mechanisms of Coronary Artery Plaques: Are We Looking for the Impossible?

Despite significant strides to mitigate the complications of acute coronary syndrome (ACS), this clinical entity still represents a major global health burden. It has so far been well-established that most of the plaques leading to ACS are not a result of gradual narrowing of the vessel lumen, but r...

Full description

Bibliographic Details
Published in:	Biomolecules
Main Authors:	Marko Kumric, Josip A. Borovac, Dinko Martinovic, Tina Ticinovic Kurir, Josko Bozic
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Subjects:	acute coronary syndrome vulnerable plaque atherosclerosis biomarkers myocardial infarction plaque rupture
Online Access:	https://www.mdpi.com/2218-273X/11/6/881

Similar Items

Plaque Vulnerability Index Predicts Cardiovascular Events: A Histological Study of an Endarterectomy Cohort
by: Isabel Goncalves, et al.
Published: (2021-08-01)

A Plaque Instability Index Calculated by Histological Marker Analysis of the Endarterectomy Carotid Artery
by: Doina Butcovan, et al.
Published: (2022-08-01)

Circulating protein biomarkers and their association with vulnerable plaque characteristics – a PROSPECT II substudy
by: Tania Sharma, et al.
Published: (2025-09-01)

Cellular crosstalk in atherosclerotic plaque microenvironment
by: Elmira Mahdinia, et al.
Published: (2023-05-01)

Geographical predisposition influences on the distribution and tissue characterisation of eccentric coronary plaques in non-branching coronary arteries: cross-sectional study of coronary plaques analysed by intravascular ultrasound
by: Hidenori Komiyama, et al.
Published: (2016-11-01)

Evaluation of the Correlation Between Distribution Location and Vulnerability of Carotid Plaque in Patients with Transient Ischemic Attack
by: Zhao Y, et al.
Published: (2024-03-01)

Beyond the Lumen: Molecular Imaging to Unmask Vulnerable Coronary Plaques
by: Geoffrey Currie, et al.
Published: (2025-01-01)

Plaque Structural Stress: Detection, Determinants and Role in Atherosclerotic Plaque Rupture and Progression
by: Sophie Z. Gu, et al.
Published: (2022-07-01)

Atherosclerotic plaque injury-mediated murine thrombosis models: advantages and limitations
by: MFA Karel, et al.
Published: (2020-05-01)

Plaque regression and plaque stabilisation in cardiovascular diseases
by: Tarun Dave, et al.
Published: (2013-01-01)

Identification Markers of Carotid Vulnerable Plaques: An Update
by: Yilin Wang, et al.
Published: (2022-08-01)

Ferroptosis: A potential target of macrophages in plaque vulnerability
by: Li Yu, et al.
Published: (2023-10-01)

Characteristics and evaluation of atherosclerotic plaques: an overview of state-of-the-art techniques
by: Zhiwei He, et al.
Published: (2023-10-01)

Current advances in the imaging of atherosclerotic vulnerable plaque using nanoparticles
by: Ming Zhang, et al.
Published: (2022-03-01)

New insights into fibrous cap thickness of vulnerable plaques assessed by optical coherence tomography
by: Xianglan Liu, et al.
Published: (2022-11-01)

Imaging Inflammation in Patients and Animals: Focus on PET Imaging the Vulnerable Plaque
by: Benjamin Bartlett, et al.
Published: (2021-09-01)

Vulnerable plaque: From bench to bedside; local pacification versus systemic therapy
by: Sazzli Kasim, et al.
Published: (2012-01-01)

Ultrasound signs of atherosclerotic plaques destabilization in carotid arteries
by: D. E. Zaitsev, et al.
Published: (2019-12-01)

Photodynamic Therapy of Atherosclerotic Plaque Monitored by T1 and T2 Relaxation Times of Magnetic Resonance Imaging
by: Piotr Wańczura, et al.
Published: (2024-08-01)

Combining IVUS + OCT Data, Biomechanical Models and Machine Learning Method for Accurate Coronary Plaque Morphology Quantification and Cap Thickness and Stress/Strain Index Predictions
by: Rui Lv, et al.
Published: (2023-01-01)

Classification of carotid atherosclerotic plaque components using T2 mapping technique from magnetic resonance imaging
by: Sranut Chunpenmongkol, et al.
Published: (2014-01-01)

Association of cardiovascular risk factors and intraplaque neovascularization in symptomatic carotid plaque
by: Zehao Liu, et al.
Published: (2024-08-01)

Effects of Nicorandil on Inflammation, Apoptosis and Atherosclerotic Plaque Progression
by: Max Lenz, et al.
Published: (2021-01-01)

Genome-scale metabolic network of human carotid plaque reveals the pivotal role of glutamine/glutamate metabolism in macrophage modulating plaque inflammation and vulnerability
by: Han Jin, et al.
Published: (2024-07-01)

Effects of norepinephrine on plaque hypoxia in atherosclerotic rabbits
by: Jia-Yu Wang, et al.
Published: (2023-02-01)

Role of 18F-FDG positron emission tomography in carotid atherosclerotic plaque imaging: A systematic review
by: Reddy Ravikanth
Published: (2020-10-01)

The Impact of Coronary Artery Calcification on Long-Term Cardiovascular Outcomes
by: Mitra Noémi, et al.
Published: (2021-03-01)

Photon-Counting Computed Tomography in Atherosclerotic Plaque Characterization
by: Riccardo Cau, et al.
Published: (2024-05-01)

Detection of Mycoplasma pneumoniae and Chlamydia pneumoniae in ruptured atherosclerotic plaques
by: M.L. Higuchi, et al.
Published: (2000-09-01)

Free-breathing, non-contrast, three-dimensional whole-heart coronary magnetic resonance imaging for the identification of culprit and vulnerable atherosclerotic plaque
by: Reza Hajhosseiny, et al.
Published: (2025-01-01)

Premature Vascular Aging with Features of Plaque Vulnerability in an Atheroprone Mouse Model of Hutchinson–Gilford Progeria Syndrome with <i>Ldlr</i> Deficiency
by: Rosa M. Nevado, et al.
Published: (2020-10-01)

NOX2 inhibition stabilizes vulnerable plaques by enhancing macrophage efferocytosis via MertK/PI3K/AKT pathway
by: Yue Wang, et al.
Published: (2023-08-01)

Comparison of multilayer and single-layer coronary plaque models on stress/strain calculations based on optical coherence tomography images
by: Mengde Huang, et al.
Published: (2023-08-01)

Multiple Plaque Ruptures with Thrombotic Occlusion
by: Vivek Singh Guleria, et al.
Published: (2025-04-01)

New Concepts on the Pathophysiology of Acute Coronary Syndrome
by: Deqiang Yuan, et al.
Published: (2023-04-01)

Classical and alternative activation and metalloproteinase expression occurs in foam cell macrophages in male and female ApoE null mice in the absence of T- and B-lymphocytes
by: Elaine Mo Hayes, et al.
Published: (2014-10-01)

Endoplasmic reticulum stress in perivascular adipose tissue promotes destabilization of atherosclerotic plaque by regulating GM-CSF paracrine
by: Ru Ying, et al.
Published: (2018-04-01)

Multimodal photoacoustic imaging in analytic vulnerability of atherosclerosis
by: Wangting Zhou, et al.
Published: (2023-12-01)

TEAD1‐Mediated Trans‐Differentiation of Vascular Smooth Muscle Cells into Fibroblast‐Like Cells Contributes to the Stabilization and Repair of Disrupted Atherosclerotic Plaques
by: Ming Zhai, et al.
Published: (2025-02-01)

Management and Outcome of Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: An Intravascular Optical Coherence Tomography Study
by: Sining Hu, et al.
Published: (2017-03-01)