Bacillus Calmette-Guérin pneumonitis after intravesical instillation: Report of two cases and a review of the literature

Objective. Intravesical administration of bacillus Calmette-Guérin is standard adjuvant treatment of non-muscle invasive bladder cancer. In spite of the fact that this immunotherapy is locoregional, there are still risk of some complications. Methods. We describe two cases of systemic BCG infection...

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Bibliographic Details
Published in:Biomedical Papers
Main Authors: Martina Spisarova, Stanislav Losse, Petr Jakubec, Igor Hartmann, Milan Kral, Jiri Ehrmann, Marek Szkorupa, Hana Studentova, Bohuslav Melichar
Format: Article
Language:English
Published: Palacký University Olomouc, Faculty of Medicine and Dentistry 2024-06-01
Subjects:
bacillus calmette-guérin
bladder cancer
intravesical therapy
Online Access:https://biomed.papers.upol.cz/artkey/bio-202402-0012_bacillus-calmette-guerin-pneumonitis-after-intravesical-instillation-report-of-two-cases-and-a-review-of-the-l.php
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Summary:Objective. Intravesical administration of bacillus Calmette-Guérin is standard adjuvant treatment of non-muscle invasive bladder cancer. In spite of the fact that this immunotherapy is locoregional, there are still risk of some complications. Methods. We describe two cases of systemic BCG infection after intravesical administration of BCG vaccine in patients with early stage of bladder cancer. Results. Both patients suffered from systemic BCG infection manifesting as BCG pneumonitis. After standard therapy with antituberculotic agents, both of them fully recovered. Conclusion. BCG infection can occur as a rare but potentially serious complication of this treatment procedure. Gravity of this side effect and its specific therapy require prompt and right diagnosis.
ISSN:1213-8118
1804-7521

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