The BH3 mimetic ABT-737 increases treatment efficiency of paclitaxel against hepatoblastoma

<p>Abstract</p> <p>Background</p> <p>The primary goal of current chemotherapy in hepatoblastoma (HB) is reduction of tumour volume and vitality to enable complete surgical resection and reduce risk of recurrence or metastatic disease. Drug resistance remains a major cha...

Full description

Bibliographic Details
Published in:	BMC Cancer
Main Authors:	Fuchs Jörg, Warmann Steven W, Kirchner Bettina, Wenz Julia, Eicher Carmen, Lieber Justus, Armeanu-Ebinger Sorin
Format:	Article
Language:	English
Published:	BMC 2011-08-01
Online Access:	http://www.biomedcentral.com/1471-2407/11/362

Similar Items

Comparison of putative BH3 mimetics AT-101, HA14-1, sabutoclax and TW-37 with ABT-737 in platelets
by: Hao Wei, et al.
Published: (2021-01-01)

HA14-1, but not the BH3 mimetic ABT-737, causes Ca2+ dysregulation in platelets and human cell lines
by: Haidar Akl, et al.
Published: (2013-04-01)

Successful establishment of an orthotopic hepatoblastoma in vivo model in NOD/LtSz-scid IL2Rγnull mice.
by: Verena Ellerkamp, et al.
Published: (2011-01-01)

BMX Acts Downstream of PI3K to Promote Colorectal Cancer Cell Survival and Pathway Inhibition Sensitizes to the BH3 Mimetic ABT-737
by: Danielle S. Potter, et al.
Published: (2014-02-01)

ABT-737 synergizes with Bortezomib to kill melanoma cells
by: Steven N. Reuland, et al.
Published: (2012-02-01)

Data on the DNA damaging and mutagenic potential of the BH3-mimetics ABT-263/Navitoclax and TW-37
by: Maja M. Green, et al.
Published: (2016-03-01)

BH3 mimetic ABT-263 enhances the anticancer effects of apigenin in tumor cells with activating EGFR mutation
by: Yihong Zhan, et al.
Published: (2019-07-01)

Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy.
by: Ryuji Yamaguchi, et al.
Published: (2011-01-01)

Melatonin Can Modulate the Effect of Navitoclax (ABT-737) in HL-60 Cells
by: Alexey Lomovsky, et al.
Published: (2020-11-01)

Evaluating the stability and efficacy of fractal-fractional models in reproductive cancer apoptosis with ABT-737
by: Kottakkaran Sooppy Nisar, et al.
Published: (2025-01-01)

Rational Formulation of targeted ABT-737 nanoparticles by self-assembled polypeptides and designed peptides
by: Polina Aibinder, et al.
Published: (2024-02-01)

Synergistic anticancer effects of the 9.2.27PE immunotoxin and ABT-737 in melanoma.
by: Karianne Risberg, et al.
Published: (2011-01-01)

The inhibition of Beclin1-dependent autophagy sensitizes PTC cells to ABT737-induced death
by: Ning Hu, et al.
Published: (2024-03-01)

MiRNA-16-1 Suppresses Mcl-1 and Bcl-2 and Sensitizes Chronic Lymphocytic Leukemia Cells to BH3 Mimetic ABT-199
by: Nooshin Ashofteh, et al.
Published: (2022-08-01)

BH3 profiling as pharmacodynamic biomarker for the activity of BH3 mimetics
by: Rongqing Aaron Pan, et al.
Published: (2023-10-01)

ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells
by: S Cristofanon, et al.
Published: (2012-11-01)

Proteasomal degradation of Mcl-1 by maritoclax induces apoptosis and enhances the efficacy of ABT-737 in melanoma cells.
by: Manoj K Pandey, et al.
Published: (2013-01-01)

ABT-737 Synergizes with Cisplatin Bypassing Aberration of Apoptotic Pathway in Non-small Cell Lung Cancer
by: Eun Young Kim, et al.
Published: (2017-04-01)

OBATOCLAX and ABT-737 induce ER stress responses in human melanoma cells that limit induction of apoptosis.
by: David Wroblewski, et al.
Published: (2013-01-01)

Correction: ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells
by: S. Cristofanon, et al.
Published: (2024-09-01)

BH3 Mimetics for the Treatment of Prostate Cancer
by: Philipp Wolf
Published: (2017-08-01)

Characterisation of the cell line HC-AFW1 derived from a pediatric hepatocellular carcinoma.
by: Sorin Armeanu-Ebinger, et al.
Published: (2012-01-01)

Sensitivity of canine hematological cancers to BH3 mimetics
by: Selvi Jegatheeson, et al.
Published: (2023-01-01)

BH3-mimetics: recent developments in cancer therapy
by: Paul A. Townsend, et al.
Published: (2021-11-01)

The BCL‐2 family protein inhibitor ABT‐737 as an additional tool for the treatment of EBV‐associated post‐transplant lymphoproliferative disorders
by: Aude Robert, et al.
Published: (2020-10-01)

ABT-737 induces Bim expression via JNK signaling pathway and its effect on the radiation sensitivity of HeLa cells.
by: Huan Wang, et al.
Published: (2012-01-01)

Computational modeling of DLBCL predicts response to BH3-mimetics
by: Ielyaas Cloete, et al.
Published: (2023-06-01)

ABT737通过激活JNK/c-Jun通路上调Bim诱导宫颈癌细胞凋亡
Published: (2013-01-01)

Upregulating Noxa by ER stress, celastrol exerts synergistic anti-cancer activity in combination with ABT-737 in human hepatocellular carcinoma cells.
by: Hong Zhu, et al.
Published: (2012-01-01)

The Combination of Ibrutinib with BH3 Mimetics or Dichloroacetate Is Effective in B-CLL
by: Joaquín Marco-Brualla, et al.
Published: (2025-08-01)

Restoring Apoptosis with BH3 Mimetics in Mature B-Cell Malignancies
by: Maxime Jullien, et al.
Published: (2020-03-01)

ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cells
by: Ricardo Parrondo, et al.
Published: (2013-09-01)

Mitochondrial apoptosis and BH3 mimetics [version 1; referees: 3 approved]
by: Haiming Dai, et al.
Published: (2016-12-01)

BCL2 Inhibitor (ABT-737): A Restorer of Prednisolone Sensitivity in Early T-Cell Precursor-Acute Lymphoblastic Leukemia with High MEF2C Expression?
by: Sachiko Kawashima-Goto, et al.
Published: (2015-01-01)

Mitotic stress-induced secretome primes cancer cells to apoptosis and maximizes paclitaxel response in breast tumors when combined with BCL-xL-targeting BH3 mimetics
by: Steven Lohard, et al.
Published: (2020-05-01)

B-cell lymphoma 2 inhibitor ABT-737 induces Beclin1- and reactive oxygen species-dependent autophagy in Adriamycin-resistant human hepatocellular carcinoma cells
by: Xiaoxiao Yao, et al.
Published: (2017-03-01)

ABT737通过延迟宫颈癌细胞放射后DNA损伤修复及诱导凋亡而增敏放疗
Published: (2013-01-01)

Inhibition of the MDM2 E3 Ligase induces apoptosis and autophagy in wild-type and mutant p53 models of multiple myeloma, and acts synergistically with ABT-737.
by: Dongmin Gu, et al.
Published: (2014-01-01)

Selective Elimination of Culture-Adapted Human Embryonic Stem Cells with BH3 Mimetics
by: Seung-Ju Cho, et al.
Published: (2018-11-01)

THE GROWING ROLE OF THE BH3 MIMETIC DRUG VENETOCLAX IN THE THERAPY OF ACUTE MYELOID LEUKEMIA
by: Elvira Pelosi, et al.
Published: (2022-10-01)