Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model
Integrins are receptors that have been linked to various brain disorders, including Alzheimer's disease (AD), the most prevalent neurodegenerative disorder. While Integrin beta-3 (ITGB3) is known to participate in multiple cellular processes such as adhesion, migration, and signaling, its speci...
| Published in: | Neurobiology of Disease |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996124000093 |
| _version_ | 1849998455604248576 |
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| author | Mariia Ivanova Irina Belaya Nina Kucháriková Izaque de Sousa Maciel Liudmila Saveleva Arto Alatalo Ilona Juvonen Navjot Thind Clarisse Andrès Riikka Lampinen Sweelin Chew Katja M. Kanninen |
| author_facet | Mariia Ivanova Irina Belaya Nina Kucháriková Izaque de Sousa Maciel Liudmila Saveleva Arto Alatalo Ilona Juvonen Navjot Thind Clarisse Andrès Riikka Lampinen Sweelin Chew Katja M. Kanninen |
| author_sort | Mariia Ivanova |
| collection | DOAJ |
| container_title | Neurobiology of Disease |
| description | Integrins are receptors that have been linked to various brain disorders, including Alzheimer's disease (AD), the most prevalent neurodegenerative disorder. While Integrin beta-3 (ITGB3) is known to participate in multiple cellular processes such as adhesion, migration, and signaling, its specific role in AD remains poorly understood, particularly in astrocytes, the main glial cell type in the brain. In this study, we investigated alterations in ITGB3 gene and protein expression during aging in different brain regions of the 5xFAD mouse model of AD and assessed the interplay between ITGB3 and astrocytes. Primary cultures from adult mouse brains were used to gain further insight into the connection between ITGB3 and amyloid beta (Aβ) in astrocytes. In vivo studies showed a correlation between ITGB3 and the astrocytic marker GFAP in the 5xFAD brains, indicating its association with reactive astrocytes. In vitro studies revealed increased gene expression of ITGB3 upon Aβ treatment. Our findings underscore the potential significance of ITGB3 in astrocyte reactivity in the context of Alzheimer's disease. |
| format | Article |
| id | doaj-art-e8c1910a22c941d385b1b2eb420e0f39 |
| institution | Directory of Open Access Journals |
| issn | 1095-953X |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| spelling | doaj-art-e8c1910a22c941d385b1b2eb420e0f392025-08-20T00:49:50ZengElsevierNeurobiology of Disease1095-953X2024-02-0119110641010.1016/j.nbd.2024.106410Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse modelMariia Ivanova0Irina Belaya1Nina Kucháriková2Izaque de Sousa Maciel3Liudmila Saveleva4Arto Alatalo5Ilona Juvonen6Navjot Thind7Clarisse Andrès8Riikka Lampinen9Sweelin Chew10Katja M. Kanninen11A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandCorresponding author.; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, FinlandIntegrins are receptors that have been linked to various brain disorders, including Alzheimer's disease (AD), the most prevalent neurodegenerative disorder. While Integrin beta-3 (ITGB3) is known to participate in multiple cellular processes such as adhesion, migration, and signaling, its specific role in AD remains poorly understood, particularly in astrocytes, the main glial cell type in the brain. In this study, we investigated alterations in ITGB3 gene and protein expression during aging in different brain regions of the 5xFAD mouse model of AD and assessed the interplay between ITGB3 and astrocytes. Primary cultures from adult mouse brains were used to gain further insight into the connection between ITGB3 and amyloid beta (Aβ) in astrocytes. In vivo studies showed a correlation between ITGB3 and the astrocytic marker GFAP in the 5xFAD brains, indicating its association with reactive astrocytes. In vitro studies revealed increased gene expression of ITGB3 upon Aβ treatment. Our findings underscore the potential significance of ITGB3 in astrocyte reactivity in the context of Alzheimer's disease.http://www.sciencedirect.com/science/article/pii/S0969996124000093Alzheimer's diseaseAstrocyte5xFAD mouseITGB3GFAPFAK |
| spellingShingle | Mariia Ivanova Irina Belaya Nina Kucháriková Izaque de Sousa Maciel Liudmila Saveleva Arto Alatalo Ilona Juvonen Navjot Thind Clarisse Andrès Riikka Lampinen Sweelin Chew Katja M. Kanninen Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model Alzheimer's disease Astrocyte 5xFAD mouse ITGB3 GFAP FAK |
| title | Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model |
| title_full | Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model |
| title_fullStr | Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model |
| title_full_unstemmed | Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model |
| title_short | Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model |
| title_sort | upregulation of integrin beta 3 in astrocytes upon alzheimer s disease progression in the 5xfad mouse model |
| topic | Alzheimer's disease Astrocyte 5xFAD mouse ITGB3 GFAP FAK |
| url | http://www.sciencedirect.com/science/article/pii/S0969996124000093 |
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