Clinical Impact of Immunoglobulin Heavy Chain Clonality in Pediatric B‐Cell Precursor Acute Lymphoblastic Leukemia

ABSTRACT Introduction Recent advancements in risk stratification have greatly improved outcomes in pediatric B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL). Despite favorable prognostic indicators, including the absence of cytogenetic abnormalities and minimal residual disease (MRD) negativ...

Full description

Bibliographic Details
Published in:	Cancer Medicine
Main Authors:	Yuta Katai, Tatsuya Kamitori, Satoshi Saida, Yoshinori Uchihara, Ryo Akazawa, Kiyotaka Isobe, Takashi Mikami, Hirohito Kubota, Itaru Kato, Katsutsugu Umeda, Hiroo Ueno, Junko Takita
Format:	Article
Language:	English
Published:	Wiley 2025-11-01
Subjects:	B‐cell lymphoblastic leukemia clonality IGH rearrangement pediatric leukemia prognosis
Online Access:	https://doi.org/10.1002/cam4.71336

Similar Items

Insights into IGH clonal evolution in BCP-ALL: frequency, mechanisms, associations, and diagnostic implications
by: Franziska Darzentas, et al.
Published: (2023-04-01)

Rapid Identification of DUX4::IGH Fusion in Acute Lymphoblastic Leukemia
by: Kyoko Moritani, et al.
Published: (2025-08-01)

Minimal residual disease detection and evolved IGH clones analysis in acute B lymphoblastic leukemia using IGH deep sequencing
by: Jinghua Wu, et al.
Published: (2016-10-01)

Corrigendum: Dogs with acute myeloid leukemia have clonal rearrangements in T and B cell receptors
by: Tracy Stokol, et al.
Published: (2025-01-01)

Recent Developments and Evolving Therapeutic Strategies in KMT2A‐Rearranged Acute Leukemia
by: Lei Yin, et al.
Published: (2024-10-01)

DNA crosslinking and recombination‐activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia
by: Hao Zhang, et al.
Published: (2021-11-01)

Lymphoblastic transformation of myelodysplastic syndrome
by: Carmen Silvia Passos Lima, et al.

Clonal Hematopoiesis, a Risk Condition for Developing Myeloid Neoplasia
by: Ugo Testa, et al.
Published: (2025-04-01)

Basophils in Acute Promyelocytic Leukemia: Clonality or Reactiveness?
by: Xue Li, et al.
Published: (2025-06-01)

STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA
by: O. V. Smirnova, et al.
Published: (2014-07-01)

Detection of New Translocation in Infant Twins with Concordant ALL and Discordant Outcome
by: Golamreza Bahoush, et al.
Published: (2020-12-01)

Younger age and induction failure predict outcomes in infant leukemia: 30 years of experience in a tertiary center
by: Bárbara Ochoa-Fernández, et al.
Published: (2023-05-01)

Cytosine arabinoside-metabolizing enzyme genes are underexpressed in children with MLL gene-rearranged acute lymphoblastic leukemia
by: J.F. Mata, et al.
Published: (2006-11-01)

Adherence to Oral Chemotherapy in Acute Lymphoblastic Leukemia during Maintenance Therapy in Children, Adolescents, and Young Adults: A Systematic Review
by: Xiaopei L. Zeng, et al.
Published: (2023-01-01)

Clonal hematopoiesis and acute myeloid leukemia
by: A. I. Kashlakova, et al.
Published: (2023-09-01)

Correction: The dark side of stemness – the role of hematopoietic stem cells in development of blood malignancies
by: Jadwiga Filipek-Gorzała, et al.
Published: (2025-06-01)

The dark side of stemness – the role of hematopoietic stem cells in development of blood malignancies
by: Jadwiga Filipek-Gorzała, et al.
Published: (2024-02-01)

Lineage switch in relapse of acute leukemia with rearrangement of MLL gene (KMT2A). literature review and case reports
by: E. A. Zerkalenkova, et al.
Published: (2016-08-01)

Surveillance and expected outcome of acute lymphoblastic leukemia in children and adolescents: An experience from Eastern India
by: Ashis Mukhopadhyay, et al.
Published: (2013-01-01)

Detection of 11q23 (MLL) rearrangements in infant acute lymphoblastic leukemia
by: G. A. Tsaur, et al.
Published: (2014-07-01)

NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization
by: Sonali Narang, et al.
Published: (2023-04-01)

Outcomes of treating infants with B-cell acute lymphoblastic leukemia at a single Latin American center: relevance of hematopoietic transplantation
by: José C. Jaime-Pérez, et al.
Published: (2025-10-01)

The causal relationship between gut microbiota and leukemia: a two-sample Mendelian randomization study
by: Guanjun Chen, et al.
Published: (2023-11-01)

Emergence of IGH::CCND1 rearrangement and mutations in TP53, BTK, and BCL2 associated with therapy resistance in chronic lymphocytic leukemia
by: Qing Wei, et al.
Published: (2024-12-01)

Infant lymphoblastic leukemia: a single centers 10 year experience
by: İnci Yaman-Bajin, et al.
Published: (2019-06-01)

Long-term and quality of survival in patients treated for acute lymphoblastic leukemia during the pediatric age
by: Lara Devilli, et al.
Published: (2021-03-01)

Understanding Patients’ Experiences in Newly Diagnosed Adult B Cell Acute Lymphoblastic Leukemia: Qualitative Interviews to Develop a Patient-Centric Conceptual Model
by: Michael Chladek, et al.
Published: (2025-04-01)

A dedicated caller for DUX4 rearrangements from whole-genome sequencing data
by: Pascal Grobecker, et al.
Published: (2025-01-01)

Co-Occurring CSF3R W791* Germline and Somatic T618I Driver Mutations Induce Early CNL and Clonal Progression to Mixed Phenotype Acute Leukemia
by: Franziska C. Adam, et al.
Published: (2022-02-01)

Certain Killer Immunoglobulin-Like Receptor (KIR)/KIR HLA Class I Ligand Genotypes Influence Natural Killer Antitumor Activity in Myelogenous Leukemia but Not in Acute Lymphoblastic Leukemia: A Case Control Leukemia Association Study
by: Viktoria Varbanova, et al.
Published: (2019-11-01)

A single scalp nodule as the first presentation of acute lymphoblastic leukemia (KMT2A::MLLT3) in a healthy-appearing infant: a case report
by: Francesco Pellegrino, et al.
Published: (2023-12-01)

NG2 MOLECULE EXPRESSION IN ACUTE LYMPHOBLASTIC LEUKEMIA B CELLS: A FLOW-CYTOMETRIC MARKER FOR THE RAPID IDENTIFICATION OF KMT2A GENE REARRANGEMENTS
by: Maria Laura Bisegna, et al.
Published: (2024-02-01)

High-Throughput Drug Library Screening in Primary <i>KMT2A</i>-Rearranged Infant ALL Cells Favors the Identification of Drug Candidates That Activate P53 Signaling
by: Priscilla Wander, et al.
Published: (2022-03-01)

Myeloid/lymphoid neoplasm with eosinophilia and BCR/FGFR1 rearrangement with transformation to cortical T-lymphoblastic lymphoma and erythroid precursors: a case report
by: Alejandro Pineda Isaza, et al.
Published: (2023-01-01)

A novel approach to treatment in childhood acute myeloblastic leukemia and myelodysplastic syndrome with high-dose methylprednisolone as a differentiation- and apoptosis-inducing agent of myeloid leukemic cells
by: Gönül Hiçsönmez
Published: (2010-03-01)

Single-cell clonal tracking of persistent T-cells in allogeneic hematopoietic stem cell transplantation
by: Benedikt Obermayer, et al.
Published: (2023-02-01)

Common in atherogenesis and carcinogenesis: clonal hematopoiesis
by: A. A. Sleptsov, et al.
Published: (2023-11-01)

Simultaneous Presentation of Hairy Cell Leukemia and Acute Lymphoblastic Leukemia
by: Mingyong Li, et al.
Published: (2021-12-01)

T-Cell Lymphoblastic Lymphoma Showing Aberrant Synaptophysin Expression in a Child
by: Nazım Emrah Koçer, et al.
Published: (2020-02-01)

Does distance to the hospital affect the course of treatment and follow-up for children with Acute Lymphoblastic Leukemia?
by: Cecilie Bjerregaard Brix, et al.
Published: (2025-02-01)